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Immune landscape characterization of neurofibromas with atypical features in Neurofibromatosis1 reveals PD-1 and the Tim-3/Galectin-9 pathway as potential therapeutic targets.

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Title: Immune landscape characterization of neurofibromas with atypical features in Neurofibromatosis1 reveals PD-1 and the Tim-3/Galectin-9 pathway as potential therapeutic targets.
Authors: Brunet A; IMRB (INSERM U955) Team Ortonne, 8 Rue du Général Sarrail, F-94010, Créteil, France.; Department of Pathology, APHP, Henri Mondor hospital, 1 rue Gustave Eiffel, F-94000, Créteil, France.; Université Paris Est Créteil, 8 rue du Général Sarrail, F-94000, Creteil, France., Coulpier F; IMRB (INSERM U955) Team Ortonne, 8 Rue du Général Sarrail, F-94010, Créteil, France., Onfroy A; IMRB (INSERM U955) Team Ortonne, 8 Rue du Général Sarrail, F-94010, Créteil, France., Sako N; IMRB (INSERM U955) Team Ortonne, 8 Rue du Général Sarrail, F-94010, Créteil, France., Radomska KJ; IMRB (INSERM U955) Team Ortonne, 8 Rue du Général Sarrail, F-94010, Créteil, France., Aftimos V; Department of Pathology, APHP, Henri Mondor hospital, 1 rue Gustave Eiffel, F-94000, Créteil, France., Lacroix L; IMRB (INSERM U955) Team Ortonne, 8 Rue du Général Sarrail, F-94010, Créteil, France., Briand-Suleau A; Institut Cochin, INSERM U1016, CNRS UMR8104, UFR de Pharmacie de Paris, Université Paris Cité, CARPEM, Paris, France., Maille P; Department of Pathology, APHP, Henri Mondor hospital, 1 rue Gustave Eiffel, F-94000, Créteil, France., Hermeziu O; Department of Plastic Surgery , APHP, Henri Mondor hospital, 1 rue Gustave Eiffel, F-94000, Créteil, France., Laurendeau I; Institut Cochin, INSERM U1016, CNRS UMR8104, UFR de Pharmacie de Paris, Université Paris Cité, CARPEM, Paris, France., Pasmant E; Institut Cochin, INSERM U1016, CNRS UMR8104, UFR de Pharmacie de Paris, Université Paris Cité, CARPEM, Paris, France.; Genetics Department, Institut Curie, 26 rue d%27Ulm, 75005, Paris, France., Wolkenstein P; IMRB (INSERM U955) Team Ortonne, 8 Rue du Général Sarrail, F-94010, Créteil, France.; Université Paris Est Créteil, 8 rue du Général Sarrail, F-94000, Creteil, France.; Department of Dermatology, APHP, Henri Mondor hospital, 1 rue Gustave Eiffel, F-94000, Créteil, France., Topilko P; IMRB (INSERM U955) Team Ortonne, 8 Rue du Général Sarrail, F-94010, Créteil, France.; Université Paris Est Créteil, 8 rue du Général Sarrail, F-94000, Creteil, France., Ortonne N; IMRB (INSERM U955) Team Ortonne, 8 Rue du Général Sarrail, F-94010, Créteil, France. nicolas.ortonne@aphp.fr.; Department of Pathology, APHP, Henri Mondor hospital, 1 rue Gustave Eiffel, F-94000, Créteil, France. nicolas.ortonne@aphp.fr.; Université Paris Est Créteil, 8 rue du Général Sarrail, F-94000, Creteil, France. nicolas.ortonne@aphp.fr.
Source: Acta neuropathologica communications [Acta Neuropathol Commun] 2026 May 03; Vol. 14 (1). Date of Electronic Publication: 2026 May 03.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="JN" term="%22101610673%22">Acta neuropathologica communications</searchLink> [Acta Neuropathol Commun] 2026 May 03; Vol. 14 (1). <i>Date of Electronic Publication: </i>2026 May 03.
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