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ISX-TWIST1 reprograms CD47-inflammasome signaling to reshape the immune microenvironment in liver cancer.

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Title: ISX-TWIST1 reprograms CD47-inflammasome signaling to reshape the immune microenvironment in liver cancer.
Authors: Wang LT; Department of Life Science, National Taiwan Normal University, Taipei, 116059, Taiwan., Lin MH; Department of Microbiology and Immunology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807378, Taiwan.; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807378, Taiwan., Li YC; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, 406040, Taiwan.; Department of Biological Science and Technology, China Medical University, Taichung, 406040, Taiwan., Wang SN; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807378, Taiwan.; Division of General and Digestive Surgery, Department of Surgery, Kaohsiung Medical University, Kaohsiung, 807378, Taiwan.; Pingtung Hospital, Ministry of Health and Welfare, Pingtung City, Pingtung County, 900027, Taiwan., Chai CY; Department of Pathology, Kaohsiung Medical University, Kaohsiung, Taiwan., Hsu JM; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, 406040, Taiwan.; Institute of Biomedical Sciences, Institute of Biochemistry and Molecular Biology, China Medical University, Taichung, 406040, Taiwan., Chiou SS; Department of Pediatrics, Faculty of Medicine, Kaohsiung Medical University Hospital, Kaohsiung, 807378, Taiwan.; Division of Hematology-Oncology, Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, 807378, Taiwan.; Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807378, Taiwan., Chiou HC; Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.; Department of Applied Chemistry, National Chi Nan University, Nantou, Taiwan., Huang SK; Teaching and Research Center, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung, 807378, Taiwan., Hung MC; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, 406040, Taiwan.; Institute of Biomedical Sciences, Institute of Biochemistry and Molecular Biology, China Medical University, Taichung, 406040, Taiwan., Hsu SH; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807378, Taiwan. jackhsu@kmu.edu.tw.; Research Center for Precision Environmental Medicine, Kaohsiung Medical University, Kaohsiung, 807378, Taiwan. jackhsu@kmu.edu.tw.; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, 807378, Taiwan. jackhsu@kmu.edu.tw.
Source: Experimental hematology & oncology [Exp Hematol Oncol] 2026 May 04; Vol. 15 (1). Date of Electronic Publication: 2026 May 04.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101590676 Publication Model: Electronic Cited Medium: Print ISSN: 2162-3619 (Print) Linking ISSN: 21623619 NLM ISO Abbreviation: Exp Hematol Oncol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: ISX-TWIST1 reprograms CD47-inflammasome signaling to reshape the immune microenvironment in liver cancer.
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  Data: <searchLink fieldCode="AU" term="%22Wang+LT%22">Wang LT</searchLink>; Department of Life Science, National Taiwan Normal University, Taipei, 116059, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+MH%22">Lin MH</searchLink>; Department of Microbiology and Immunology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807378, Taiwan.; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807378, Taiwan.<br /><searchLink fieldCode="AU" term="%22Li+YC%22">Li YC</searchLink>; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, 406040, Taiwan.; Department of Biological Science and Technology, China Medical University, Taichung, 406040, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+SN%22">Wang SN</searchLink>; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807378, Taiwan.; Division of General and Digestive Surgery, Department of Surgery, Kaohsiung Medical University, Kaohsiung, 807378, Taiwan.; Pingtung Hospital, Ministry of Health and Welfare, Pingtung City, Pingtung County, 900027, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chai+CY%22">Chai CY</searchLink>; Department of Pathology, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsu+JM%22">Hsu JM</searchLink>; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, 406040, Taiwan.; Institute of Biomedical Sciences, Institute of Biochemistry and Molecular Biology, China Medical University, Taichung, 406040, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiou+SS%22">Chiou SS</searchLink>; Department of Pediatrics, Faculty of Medicine, Kaohsiung Medical University Hospital, Kaohsiung, 807378, Taiwan.; Division of Hematology-Oncology, Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, 807378, Taiwan.; Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807378, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiou+HC%22">Chiou HC</searchLink>; Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.; Department of Applied Chemistry, National Chi Nan University, Nantou, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+SK%22">Huang SK</searchLink>; Teaching and Research Center, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung, 807378, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hung+MC%22">Hung MC</searchLink>; Cancer Biology and Precision Therapeutics Center, China Medical University, Taichung, 406040, Taiwan.; Institute of Biomedical Sciences, Institute of Biochemistry and Molecular Biology, China Medical University, Taichung, 406040, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsu+SH%22">Hsu SH</searchLink>; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807378, Taiwan. jackhsu@kmu.edu.tw.; Research Center for Precision Environmental Medicine, Kaohsiung Medical University, Kaohsiung, 807378, Taiwan. jackhsu@kmu.edu.tw.; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, 807378, Taiwan. jackhsu@kmu.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%22101590676%22">Experimental hematology & oncology</searchLink> [Exp Hematol Oncol] 2026 May 04; Vol. 15 (1). <i>Date of Electronic Publication: </i>2026 May 04.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101590676 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2162-3619 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2221623619%22">21623619 </searchLink><i>NLM ISO Abbreviation: </i>Exp Hematol Oncol <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1186/s40164-026-00777-1
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      – Code: eng
        Text: English
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      – TitleFull: ISX-TWIST1 reprograms CD47-inflammasome signaling to reshape the immune microenvironment in liver cancer.
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            NameFull: Wang LT
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            – D: 04
              M: 05
              Text: 2026 May 04
              Type: published
              Y: 2026
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