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Reproductive history differentially shapes the neural response of middle-aged hAPOEɛ4 female rats to estradiol therapy after a metabolic challenge.

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Title: Reproductive history differentially shapes the neural response of middle-aged hAPOEɛ4 female rats to estradiol therapy after a metabolic challenge.
Authors: Richard JE; Centre for Addiction and Mental Health, Toronto, ON, Canada.; Department of Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada., Mohammad A; Centre for Addiction and Mental Health, Toronto, ON, Canada.; Institute of Medical Sciences, University of Toronto, Toronto, Canada., Lieblich SE; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada., Go KA; Centre for Addiction and Mental Health, Toronto, ON, Canada.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada., Wang S; Centre for Addiction and Mental Health, Toronto, ON, Canada., Rechlin RK; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada., Splinter TFL; Centre for Addiction and Mental Health, Toronto, ON, Canada., Barreto GE; Department of Biological Sciences, University of Limerick, Limerick, Ireland., Galea LAM; Centre for Addiction and Mental Health, Toronto, ON, Canada. liisa.galea@utoronto.ca.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada. liisa.galea@utoronto.ca.; Institute of Medical Sciences, University of Toronto, Toronto, Canada. liisa.galea@utoronto.ca.; Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada. liisa.galea@utoronto.ca.; Department of Psychiatry, University of Toronto, Toronto, Canada. liisa.galea@utoronto.ca.
Source: Biology of sex differences [Biol Sex Differ] 2026 May 03; Vol. 17 (1). Date of Electronic Publication: 2026 May 03.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101548963 Publication Model: Electronic Cited Medium: Internet ISSN: 2042-6410 (Electronic) Linking ISSN: 20426410 NLM ISO Abbreviation: Biol Sex Differ Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Reproductive history differentially shapes the neural response of middle-aged hAPOEɛ4 female rats to estradiol therapy after a metabolic challenge.
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  Data: <searchLink fieldCode="AU" term="%22Richard+JE%22">Richard JE</searchLink>; Centre for Addiction and Mental Health, Toronto, ON, Canada.; Department of Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Mohammad+A%22">Mohammad A</searchLink>; Centre for Addiction and Mental Health, Toronto, ON, Canada.; Institute of Medical Sciences, University of Toronto, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Lieblich+SE%22">Lieblich SE</searchLink>; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Go+KA%22">Go KA</searchLink>; Centre for Addiction and Mental Health, Toronto, ON, Canada.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Centre for Addiction and Mental Health, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Rechlin+RK%22">Rechlin RK</searchLink>; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Splinter+TFL%22">Splinter TFL</searchLink>; Centre for Addiction and Mental Health, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Barreto+GE%22">Barreto GE</searchLink>; Department of Biological Sciences, University of Limerick, Limerick, Ireland.<br /><searchLink fieldCode="AU" term="%22Galea+LAM%22">Galea LAM</searchLink>; Centre for Addiction and Mental Health, Toronto, ON, Canada. liisa.galea@utoronto.ca.; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada. liisa.galea@utoronto.ca.; Institute of Medical Sciences, University of Toronto, Toronto, Canada. liisa.galea@utoronto.ca.; Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada. liisa.galea@utoronto.ca.; Department of Psychiatry, University of Toronto, Toronto, Canada. liisa.galea@utoronto.ca.
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  Data: <searchLink fieldCode="JN" term="%22101548963%22">Biology of sex differences</searchLink> [Biol Sex Differ] 2026 May 03; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 May 03.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101548963 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2042-6410 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220426410%22">20426410 </searchLink><i>NLM ISO Abbreviation: </i>Biol Sex Differ <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s13293-026-00911-y
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        Text: English
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              Text: 2026 May 03
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