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Optimizing riociguat therapy for pulmonary hypertension: A systematic review and meta-analysis of dose variability, safety, and efficacy.

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Title: Optimizing riociguat therapy for pulmonary hypertension: A systematic review and meta-analysis of dose variability, safety, and efficacy.
Authors: Faizan MA; Department of Medicine, Gomal Medical College, Khyber Medical University, Pakistan., Rehman T; Department of Medicine, Gomal Medical College, Khyber Medical University, Pakistan., Malik H; Department of Medicine, Fazaia Ruth Pfau Medical College, Karachi, Pakistan., Hudaib M; Department of Medicine, Fazaia Ruth Pfau Medical College, Karachi, Pakistan., Tahir MA; Department of Medicine, Fazaia Ruth Pfau Medical College, Karachi, Pakistan., Ohri G; Department of Medicine, Dr. Sampurnanand Medical College, Jodhpur, India., Bano S; Department of Medicine, Ayub Medical College, Abbottabad, Pakistan., Fatima L; Department of Medicine, Allama Iqbal Medical College, Lahore, Pakistan., Ahmed SH; Department of Medicine, Ruth KM Pfau Civil Hospital, Karachi, Pakistan., Karam AU; Department of Medicine, Fazaia Ruth Pfau Medical College, Karachi, Pakistan., Ahmed Z; Department of Medicine, Fazaia Ruth Pfau Medical College, Karachi, Pakistan., Rehman A; Department of Medicine, Fazaia Ruth Pfau Medical College, Karachi, Pakistan., Rabbani S; Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan., Dandamudi M; Department of Medicine, Montefiore Einstein Hospital, New York, NY., Mahmmoud Fadelallah Eljack M; Department of Community Medicine, University of Bakht Alruda, Ed Dueim, Sudan., Humayun Z; Department of Medicine, University of Missouri, Kansas City, MO.
Source: Medicine [Medicine (Baltimore)] 2026 Apr 24; Vol. 105 (17), pp. e46007.
Publication Type: Journal Article; Systematic Review; Meta-Analysis
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Faizan+MA%22">Faizan MA</searchLink>; Department of Medicine, Gomal Medical College, Khyber Medical University, Pakistan.<br /><searchLink fieldCode="AU" term="%22Rehman+T%22">Rehman T</searchLink>; Department of Medicine, Gomal Medical College, Khyber Medical University, Pakistan.<br /><searchLink fieldCode="AU" term="%22Malik+H%22">Malik H</searchLink>; Department of Medicine, Fazaia Ruth Pfau Medical College, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Hudaib+M%22">Hudaib M</searchLink>; Department of Medicine, Fazaia Ruth Pfau Medical College, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Tahir+MA%22">Tahir MA</searchLink>; Department of Medicine, Fazaia Ruth Pfau Medical College, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Ohri+G%22">Ohri G</searchLink>; Department of Medicine, Dr. Sampurnanand Medical College, Jodhpur, India.<br /><searchLink fieldCode="AU" term="%22Bano+S%22">Bano S</searchLink>; Department of Medicine, Ayub Medical College, Abbottabad, Pakistan.<br /><searchLink fieldCode="AU" term="%22Fatima+L%22">Fatima L</searchLink>; Department of Medicine, Allama Iqbal Medical College, Lahore, Pakistan.<br /><searchLink fieldCode="AU" term="%22Ahmed+SH%22">Ahmed SH</searchLink>; Department of Medicine, Ruth KM Pfau Civil Hospital, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Karam+AU%22">Karam AU</searchLink>; Department of Medicine, Fazaia Ruth Pfau Medical College, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Ahmed+Z%22">Ahmed Z</searchLink>; Department of Medicine, Fazaia Ruth Pfau Medical College, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Rehman+A%22">Rehman A</searchLink>; Department of Medicine, Fazaia Ruth Pfau Medical College, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Rabbani+S%22">Rabbani S</searchLink>; Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan.<br /><searchLink fieldCode="AU" term="%22Dandamudi+M%22">Dandamudi M</searchLink>; Department of Medicine, Montefiore Einstein Hospital, New York, NY.<br /><searchLink fieldCode="AU" term="%22Mahmmoud+Fadelallah+Eljack+M%22">Mahmmoud Fadelallah Eljack M</searchLink>; Department of Community Medicine, University of Bakht Alruda, Ed Dueim, Sudan.<br /><searchLink fieldCode="AU" term="%22Humayun+Z%22">Humayun Z</searchLink>; Department of Medicine, University of Missouri, Kansas City, MO.
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  Data: <searchLink fieldCode="JN" term="%222985248R%22">Medicine</searchLink> [Medicine (Baltimore)] 2026 Apr 24; Vol. 105 (17), pp. e46007.
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