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Efficacy of Second-Line Advanced Therapy in Patients with Crohn's Disease After Failure of a First Anti-TNF: A Descriptive Analysis.

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Title: Efficacy of Second-Line Advanced Therapy in Patients with Crohn's Disease After Failure of a First Anti-TNF: A Descriptive Analysis.
Authors: Meianu C; UMF 'Carol Davila', Gastroenterology & Hepatology Department, 020021 Bucharest, Romania.; Gastroenterology & Hepatology Department, Clinic Fundeni Institute, 022328 Bucharest, Romania., Preda CM; UMF 'Carol Davila', Gastroenterology & Hepatology Department, 020021 Bucharest, Romania.; Gastroenterology & Hepatology Department, Clinic Fundeni Institute, 022328 Bucharest, Romania., Diculescu M; UMF 'Carol Davila', Gastroenterology & Hepatology Department, 020021 Bucharest, Romania.; Gastroenterology & Hepatology Department, Clinic Fundeni Institute, 022328 Bucharest, Romania., Istratescu D; Gastroenterology & Hepatology Department, Clinic Fundeni Institute, 022328 Bucharest, Romania., Trifan A; Department of Gastroenterology, Faculty of Medicine, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iasi, Romania.; Institute of Gastroenterology and Hepatology, 'St. Spiridon' University Hospital, 700111 Iasi, Romania., Tantau A; Cluj CF University Hospital, UMF 'Iuliu Hatieganu' Cluj, 400347 Cluj, Romania., Singeap AM; Department of Gastroenterology, Faculty of Medicine, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iasi, Romania.; Institute of Gastroenterology and Hepatology, 'St. Spiridon' University Hospital, 700111 Iasi, Romania., Tieranu CG; UMF 'Carol Davila', Gastroenterology & Hepatology Department, 020021 Bucharest, Romania.; Gastroenterology & Hepatology Department, Elias Emergency Hospital, 011461 Bucharest, Romania., Minea H; Department of Gastroenterology, Faculty of Medicine, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iasi, Romania.; Institute of Gastroenterology and Hepatology, 'St. Spiridon' University Hospital, 700111 Iasi, Romania., Buzuleac AM; Department of Gastroenterology, Faculty of Medicine, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iasi, Romania.; Institute of Gastroenterology and Hepatology, 'St. Spiridon' University Hospital, 700111 Iasi, Romania., Negreanu L; UMF 'Carol Davila', Gastroenterology & Hepatology Department, 020021 Bucharest, Romania.; Internal Medicine Department, Emergency Universitary Hospital, 050471 Bucharest, Romania., Popescu R; Internal Medicine Department, Emergency Universitary Hospital, 050471 Bucharest, Romania., Bota A; Gastroenterology & Hepatology Department, Elias Emergency Hospital, 011461 Bucharest, Romania., Stroie T; UMF 'Carol Davila', Gastroenterology & Hepatology Department, 020021 Bucharest, Romania.; Gastroenterology & Hepatology Department, Clinic Fundeni Institute, 022328 Bucharest, Romania., Tugui L; Gastroenterology & Hepatology Department, Clinic Fundeni Institute, 022328 Bucharest, Romania., Cazimirovitz AM; Gastroenterology & Hepatology Department, Elias Emergency Hospital, 011461 Bucharest, Romania., Ciora CA; UMF 'Carol Davila', Gastroenterology & Hepatology Department, 020021 Bucharest, Romania.; Gastroenterology & Hepatology Department, Clinic Fundeni Institute, 022328 Bucharest, Romania.
Source: Journal of clinical medicine [J Clin Med] 2026 Apr 16; Vol. 15 (8). Date of Electronic Publication: 2026 Apr 16.
Publication Type: Journal Article
Journal Info: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101606588 Publication Model: Electronic Cited Medium: Print ISSN: 2077-0383 (Print) Linking ISSN: 20770383 NLM ISO Abbreviation: J Clin Med Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Efficacy of Second-Line Advanced Therapy in Patients with Crohn's Disease After Failure of a First Anti-TNF: A Descriptive Analysis.
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  Data: <searchLink fieldCode="AU" term="%22Meianu+C%22">Meianu C</searchLink>; UMF 'Carol Davila', Gastroenterology & Hepatology Department, 020021 Bucharest, Romania.; Gastroenterology & Hepatology Department, Clinic Fundeni Institute, 022328 Bucharest, Romania.<br /><searchLink fieldCode="AU" term="%22Preda+CM%22">Preda CM</searchLink>; UMF 'Carol Davila', Gastroenterology & Hepatology Department, 020021 Bucharest, Romania.; Gastroenterology & Hepatology Department, Clinic Fundeni Institute, 022328 Bucharest, Romania.<br /><searchLink fieldCode="AU" term="%22Diculescu+M%22">Diculescu M</searchLink>; UMF 'Carol Davila', Gastroenterology & Hepatology Department, 020021 Bucharest, Romania.; Gastroenterology & Hepatology Department, Clinic Fundeni Institute, 022328 Bucharest, Romania.<br /><searchLink fieldCode="AU" term="%22Istratescu+D%22">Istratescu D</searchLink>; Gastroenterology & Hepatology Department, Clinic Fundeni Institute, 022328 Bucharest, Romania.<br /><searchLink fieldCode="AU" term="%22Trifan+A%22">Trifan A</searchLink>; Department of Gastroenterology, Faculty of Medicine, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iasi, Romania.; Institute of Gastroenterology and Hepatology, 'St. Spiridon' University Hospital, 700111 Iasi, Romania.<br /><searchLink fieldCode="AU" term="%22Tantau+A%22">Tantau A</searchLink>; Cluj CF University Hospital, UMF 'Iuliu Hatieganu' Cluj, 400347 Cluj, Romania.<br /><searchLink fieldCode="AU" term="%22Singeap+AM%22">Singeap AM</searchLink>; Department of Gastroenterology, Faculty of Medicine, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iasi, Romania.; Institute of Gastroenterology and Hepatology, 'St. Spiridon' University Hospital, 700111 Iasi, Romania.<br /><searchLink fieldCode="AU" term="%22Tieranu+CG%22">Tieranu CG</searchLink>; UMF 'Carol Davila', Gastroenterology & Hepatology Department, 020021 Bucharest, Romania.; Gastroenterology & Hepatology Department, Elias Emergency Hospital, 011461 Bucharest, Romania.<br /><searchLink fieldCode="AU" term="%22Minea+H%22">Minea H</searchLink>; Department of Gastroenterology, Faculty of Medicine, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iasi, Romania.; Institute of Gastroenterology and Hepatology, 'St. Spiridon' University Hospital, 700111 Iasi, Romania.<br /><searchLink fieldCode="AU" term="%22Buzuleac+AM%22">Buzuleac AM</searchLink>; Department of Gastroenterology, Faculty of Medicine, University of Medicine and Pharmacy 'Grigore T. Popa', 700115 Iasi, Romania.; Institute of Gastroenterology and Hepatology, 'St. Spiridon' University Hospital, 700111 Iasi, Romania.<br /><searchLink fieldCode="AU" term="%22Negreanu+L%22">Negreanu L</searchLink>; UMF 'Carol Davila', Gastroenterology & Hepatology Department, 020021 Bucharest, Romania.; Internal Medicine Department, Emergency Universitary Hospital, 050471 Bucharest, Romania.<br /><searchLink fieldCode="AU" term="%22Popescu+R%22">Popescu R</searchLink>; Internal Medicine Department, Emergency Universitary Hospital, 050471 Bucharest, Romania.<br /><searchLink fieldCode="AU" term="%22Bota+A%22">Bota A</searchLink>; Gastroenterology & Hepatology Department, Elias Emergency Hospital, 011461 Bucharest, Romania.<br /><searchLink fieldCode="AU" term="%22Stroie+T%22">Stroie T</searchLink>; UMF 'Carol Davila', Gastroenterology & Hepatology Department, 020021 Bucharest, Romania.; Gastroenterology & Hepatology Department, Clinic Fundeni Institute, 022328 Bucharest, Romania.<br /><searchLink fieldCode="AU" term="%22Tugui+L%22">Tugui L</searchLink>; Gastroenterology & Hepatology Department, Clinic Fundeni Institute, 022328 Bucharest, Romania.<br /><searchLink fieldCode="AU" term="%22Cazimirovitz+AM%22">Cazimirovitz AM</searchLink>; Gastroenterology & Hepatology Department, Elias Emergency Hospital, 011461 Bucharest, Romania.<br /><searchLink fieldCode="AU" term="%22Ciora+CA%22">Ciora CA</searchLink>; UMF 'Carol Davila', Gastroenterology & Hepatology Department, 020021 Bucharest, Romania.; Gastroenterology & Hepatology Department, Clinic Fundeni Institute, 022328 Bucharest, Romania.
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