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Adjunctive Pentoxifylline Enhances Clinical Remission and Reduces Inflammatory Biomarkers in Mild-to-Moderate Ulcerative Colitis: A Randomized Double-Blind Placebo-Controlled Pilot Trial.

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Title: Adjunctive Pentoxifylline Enhances Clinical Remission and Reduces Inflammatory Biomarkers in Mild-to-Moderate Ulcerative Colitis: A Randomized Double-Blind Placebo-Controlled Pilot Trial.
Authors: Khrieba MO; Pharmacy Practice Department, Faculty of Pharmacy, Horus University-Egypt, New Damietta 34517, Egypt.; Pharmacy Practice Department, Faculty of Pharmacy, East Port Said National University, Port Said 42511, Egypt., Abdulelah FM; Clinical Pharmacy Department, College of Pharmacy, Al-Naji University, Baghdad 10015, Iraq., Badawoud AM; Department of Pharmacy Practice, College of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia., Hamza E; Department of Biochemistry, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 13317, Saudi Arabia., Al-Dhelaan RA; Department of Biochemistry, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 13317, Saudi Arabia., Ahmed TI; Internal Medicine Department, Faculty of Medicine, Fayoum University, Fayoum 63514, Egypt., Abdelhameed AG; Pharmacology and Toxicology Department, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.; Pharmacology and Biochemistry Department, Faculty of Pharmacy, Horus University-Egypt, New Damietta 34517, Egypt., Elshorbagi N; Pharmacology and Toxicology Department, Faculty of Pharmacy, Sinai University, East Kantara Branch, Ismailia 41636, Egypt., El-Hanafy DA; Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt., Eltantawy N; Clinical Pharmacy and Pharmacy Practice Department, Faculty of Pharmacy, Egyptian Russian University, Badr City 11829, Cairo, Egypt., Salahuddin MM; Pharmacology and Biochemistry Department, Faculty of Pharmacy, Horus University-Egypt, New Damietta 34517, Egypt., Elkhodary NM; Department of Clinical Pharmacy, Faculty of Pharmacy, Kafrelsheikh University, Kafr El-Sheikh 33516, Egypt., Radwan KH; Biochemistry Department, Horus University-Egypt, New Damietta 34517, Egypt., Khalaf Ali KAB; Tropical Medicine and Gastroenterology Department, Faculty of Medicine, Assiut University, Assiut 71515, Egypt., El-Sayed AA; Department of Pharmacy Practice, Faculty of Pharmacy, Arish Branch, Sinai University, Arish 45511, Egypt., Kamal M; Clinical Pharmacy Department, Faculty of Pharmacy, Fayoum University, Fayoum 63514, Egypt.
Source: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2026 Mar 30; Vol. 19 (4). Date of Electronic Publication: 2026 Mar 30.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238453 Publication Model: Electronic Cited Medium: Print ISSN: 1424-8247 (Print) Linking ISSN: 14248247 NLM ISO Abbreviation: Pharmaceuticals (Basel) Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Adjunctive Pentoxifylline Enhances Clinical Remission and Reduces Inflammatory Biomarkers in Mild-to-Moderate Ulcerative Colitis: A Randomized Double-Blind Placebo-Controlled Pilot Trial.
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  Data: <searchLink fieldCode="AU" term="%22Khrieba+MO%22">Khrieba MO</searchLink>; Pharmacy Practice Department, Faculty of Pharmacy, Horus University-Egypt, New Damietta 34517, Egypt.; Pharmacy Practice Department, Faculty of Pharmacy, East Port Said National University, Port Said 42511, Egypt.<br /><searchLink fieldCode="AU" term="%22Abdulelah+FM%22">Abdulelah FM</searchLink>; Clinical Pharmacy Department, College of Pharmacy, Al-Naji University, Baghdad 10015, Iraq.<br /><searchLink fieldCode="AU" term="%22Badawoud+AM%22">Badawoud AM</searchLink>; Department of Pharmacy Practice, College of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Hamza+E%22">Hamza E</searchLink>; Department of Biochemistry, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 13317, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Al-Dhelaan+RA%22">Al-Dhelaan RA</searchLink>; Department of Biochemistry, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 13317, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Ahmed+TI%22">Ahmed TI</searchLink>; Internal Medicine Department, Faculty of Medicine, Fayoum University, Fayoum 63514, Egypt.<br /><searchLink fieldCode="AU" term="%22Abdelhameed+AG%22">Abdelhameed AG</searchLink>; Pharmacology and Toxicology Department, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.; Pharmacology and Biochemistry Department, Faculty of Pharmacy, Horus University-Egypt, New Damietta 34517, Egypt.<br /><searchLink fieldCode="AU" term="%22Elshorbagi+N%22">Elshorbagi N</searchLink>; Pharmacology and Toxicology Department, Faculty of Pharmacy, Sinai University, East Kantara Branch, Ismailia 41636, Egypt.<br /><searchLink fieldCode="AU" term="%22El-Hanafy+DA%22">El-Hanafy DA</searchLink>; Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.<br /><searchLink fieldCode="AU" term="%22Eltantawy+N%22">Eltantawy N</searchLink>; Clinical Pharmacy and Pharmacy Practice Department, Faculty of Pharmacy, Egyptian Russian University, Badr City 11829, Cairo, Egypt.<br /><searchLink fieldCode="AU" term="%22Salahuddin+MM%22">Salahuddin MM</searchLink>; Pharmacology and Biochemistry Department, Faculty of Pharmacy, Horus University-Egypt, New Damietta 34517, Egypt.<br /><searchLink fieldCode="AU" term="%22Elkhodary+NM%22">Elkhodary NM</searchLink>; Department of Clinical Pharmacy, Faculty of Pharmacy, Kafrelsheikh University, Kafr El-Sheikh 33516, Egypt.<br /><searchLink fieldCode="AU" term="%22Radwan+KH%22">Radwan KH</searchLink>; Biochemistry Department, Horus University-Egypt, New Damietta 34517, Egypt.<br /><searchLink fieldCode="AU" term="%22Khalaf+Ali+KAB%22">Khalaf Ali KAB</searchLink>; Tropical Medicine and Gastroenterology Department, Faculty of Medicine, Assiut University, Assiut 71515, Egypt.<br /><searchLink fieldCode="AU" term="%22El-Sayed+AA%22">El-Sayed AA</searchLink>; Department of Pharmacy Practice, Faculty of Pharmacy, Arish Branch, Sinai University, Arish 45511, Egypt.<br /><searchLink fieldCode="AU" term="%22Kamal+M%22">Kamal M</searchLink>; Clinical Pharmacy Department, Faculty of Pharmacy, Fayoum University, Fayoum 63514, Egypt.
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  Data: <searchLink fieldCode="JN" term="%22101238453%22">Pharmaceuticals (Basel, Switzerland)</searchLink> [Pharmaceuticals (Basel)] 2026 Mar 30; Vol. 19 (4). <i>Date of Electronic Publication: </i>2026 Mar 30.
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      – TitleFull: Adjunctive Pentoxifylline Enhances Clinical Remission and Reduces Inflammatory Biomarkers in Mild-to-Moderate Ulcerative Colitis: A Randomized Double-Blind Placebo-Controlled Pilot Trial.
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