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Outcomes of first-line chemo-immunotherapy in advanced non-squamous NSCLC according to KRAS status: An Italian real-world study.

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Title: Outcomes of first-line chemo-immunotherapy in advanced non-squamous NSCLC according to KRAS status: An Italian real-world study.
Authors: Leonetti A; Medical Oncology Unit, University Hospital of Parma, Parma, Italy., Callegari V; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, Italy., Perrone F; Medical Oncology Unit, University Hospital of Parma, Parma, Italy., Maglietta G; Clinical & Epidemiological Research Unit, University Hospital of Parma, Parma, Italy., Bordi P; Medical Oncology Unit, University Hospital of Parma, Parma, Italy., Bria E; UOSD Oncologia Toraco-Polmonare, Comprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.; Medical Oncology, Department of Traslational Medicine and Surgery, Universita` Cattolica del Sacro Cuore, Rome, Italy., Vita E; UOSD Oncologia Toraco-Polmonare, Comprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.; Medical Oncology, Department of Traslational Medicine and Surgery, Universita` Cattolica del Sacro Cuore, Rome, Italy., Gelsomino F; Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy., De Giglio A; Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy., Gelibter A; Medical Oncology (B), Policlinico Umberto I, 'Sapienza' University of Rome, Rome, Italy., Siringo M; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy., Mazzoni F; Department of Oncology, Careggi University Hospital, Florence, Italy., Caliman E; Department of Oncology, Careggi University Hospital, Florence, Italy., Genova C; Academic Oncology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.; Department of Internal Medicine and Medical Specialties, University of Genoa, Genoa, Italy., Barletta G; Academic Oncology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Bertolini F; Division of Oncology, Department of Oncology and Hematology, University Hospital of Modena, Modena, Italy., Guaitoli G; Division of Oncology, Department of Oncology and Hematology, University Hospital of Modena, Modena, Italy., Passiglia F; Department of Oncology, University of Turin, AOU San Luigi Gonzaga, Orbassano, Turin, Italy., Delcuratolo MD; Medical Oncology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy., Montrone M; Medical Thoracic Oncology Unit, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy., Oresti S; Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy., Pasello G; Medical Oncology 2, Istituto Oncologico Veneto IRCCS, Padua, Italy.; Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy., Roca E; Thoracic Oncology - Lung Unit, Pederzoli Hospital, Peschiera del Garda, Italy., Belluomini L; Section of Innovation Biomedicine-Oncology Area, Department of Engineering for Innovation Medicine, University of Verona School of Medicine and Verona University Hospital Trust, Verona, Italy., Cecere FL; Oncology 1, Regina Elena National Cancer Institute IRCCS Rome, Rome, Italy., Guida A; Department of Medical Oncology, St. Mary's Hospital, Terni, Italy., Manzo A; Thoracic Medical Oncology, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Naples, Italy., Russo A; Medical Oncology Department, Humanitas Istituto Clinico Catanese, Misterbianco, Catania, Italy.; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy., Rastelli F; Medical Oncology, AST (Azienda Sanitaria Territoriale) of Ascoli Piceno, Ascoli Piceno, Italy., Bulotta A; Department of Oncology, Istituto di Ricerca a Carattere Scientifico (IRCCS) San Raffaele Hospital, Milan, Italy., Citarella F; Department of Medical Oncology, Campus Bio-Medico University, Rome, Italy., Toschi L; IRCCS Humanitas Research Hospital - Medical Oncology, Rozzano, Milan, Italy., Zoratto F; Medical Oncology, Santa Maria Goretti Hospital, Latina, Italy., Cortinovis DL; SC Medical Oncology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; Medicine and Surgery Department, University of Milano Bicocca, Milan, Italy., Paoloni F; Oncology Clinic, Universita ` Politecnica Delle Marche, Ospedali Riuniti Di Ancona, Ancona, Italy., Follador A; Medical Oncology Unit San Daniele - Tolmezzo, ASUFC Azienda Sanitaria Universitaria Friuli Centrale, Italy., Carta A; Pathology and Oncology Unit, Businco Oncological Hospital, Cagliari, Italy., Camerini A; Medical Oncology, Versilia Hospital, Azienda USL Toscana Nord Ovest, Lido di Camaiore, Italy., Salerno F; Department of Oncology, University of Turin, Ordine Mauriziano Hospital, Turin, Italy., Silva RR; Department of Oncology, ASUR Marche, Area Vasta 2, Fabriano, Italy., Baldini E; Medical Oncology Unit, San Luca Hospital, Lucca, Italy., Ficorella C; Department of Biotechnological and Applied Clinical Sciences, St Salvatore Hospital, University of L'Aquila, L'Aquila, Italy., Brighenti M; Medical Oncology, ASST Cremona, Cremona, Italy., Santoni M; Oncology Unit, Macerata Hospital, Macerata, Italy., Malorgio F; Department of Oncology, Spirito Santo Hospital, Pescara, Italy., Caminiti C; Clinical & Epidemiological Research Unit, University Hospital of Parma, Parma, Italy., Puntoni M; Clinical & Epidemiological Research Unit, University Hospital of Parma, Parma, Italy., Tiseo M; Medical Oncology Unit, University Hospital of Parma, Parma, Italy.; Department of Medicine and Surgery, University of Parma, Parma, Italy.
Source: Tumori [Tumori] 2026 Aug; Vol. 112 (4), pp. 316-324. Date of Electronic Publication: 2026 May 04.
Publication Type: Journal Article
Journal Info: Publisher: Sage Publications Country of Publication: United States NLM ID: 0111356 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2038-2529 (Electronic) Linking ISSN: 03008916 NLM ISO Abbreviation: Tumori Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Outcomes of first-line chemo-immunotherapy in advanced non-squamous NSCLC according to KRAS status: An Italian real-world study.
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  Data: <searchLink fieldCode="AU" term="%22Leonetti+A%22">Leonetti A</searchLink>; Medical Oncology Unit, University Hospital of Parma, Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Callegari+V%22">Callegari V</searchLink>; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Perrone+F%22">Perrone F</searchLink>; Medical Oncology Unit, University Hospital of Parma, Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Maglietta+G%22">Maglietta G</searchLink>; Clinical & Epidemiological Research Unit, University Hospital of Parma, Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Bordi+P%22">Bordi P</searchLink>; Medical Oncology Unit, University Hospital of Parma, Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Bria+E%22">Bria E</searchLink>; UOSD Oncologia Toraco-Polmonare, Comprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.; Medical Oncology, Department of Traslational Medicine and Surgery, Universita` Cattolica del Sacro Cuore, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Vita+E%22">Vita E</searchLink>; UOSD Oncologia Toraco-Polmonare, Comprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.; Medical Oncology, Department of Traslational Medicine and Surgery, Universita` Cattolica del Sacro Cuore, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Gelsomino+F%22">Gelsomino F</searchLink>; Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22De+Giglio+A%22">De Giglio A</searchLink>; Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Gelibter+A%22">Gelibter A</searchLink>; Medical Oncology (B), Policlinico Umberto I, 'Sapienza' University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Siringo+M%22">Siringo M</searchLink>; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Mazzoni+F%22">Mazzoni F</searchLink>; Department of Oncology, Careggi University Hospital, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Caliman+E%22">Caliman E</searchLink>; Department of Oncology, Careggi University Hospital, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Genova+C%22">Genova C</searchLink>; Academic Oncology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.; Department of Internal Medicine and Medical Specialties, University of Genoa, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Barletta+G%22">Barletta G</searchLink>; Academic Oncology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Bertolini+F%22">Bertolini F</searchLink>; Division of Oncology, Department of Oncology and Hematology, University Hospital of Modena, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Guaitoli+G%22">Guaitoli G</searchLink>; Division of Oncology, Department of Oncology and Hematology, University Hospital of Modena, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Passiglia+F%22">Passiglia F</searchLink>; Department of Oncology, University of Turin, AOU San Luigi Gonzaga, Orbassano, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Delcuratolo+MD%22">Delcuratolo MD</searchLink>; Medical Oncology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.<br /><searchLink fieldCode="AU" term="%22Montrone+M%22">Montrone M</searchLink>; Medical Thoracic Oncology Unit, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Oresti+S%22">Oresti S</searchLink>; Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Pasello+G%22">Pasello G</searchLink>; Medical Oncology 2, Istituto Oncologico Veneto IRCCS, Padua, Italy.; Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Roca+E%22">Roca E</searchLink>; Thoracic Oncology - Lung Unit, Pederzoli Hospital, Peschiera del Garda, Italy.<br /><searchLink fieldCode="AU" term="%22Belluomini+L%22">Belluomini L</searchLink>; Section of Innovation Biomedicine-Oncology Area, Department of Engineering for Innovation Medicine, University of Verona School of Medicine and Verona University Hospital Trust, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Cecere+FL%22">Cecere FL</searchLink>; Oncology 1, Regina Elena National Cancer Institute IRCCS Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Guida+A%22">Guida A</searchLink>; Department of Medical Oncology, St. Mary's Hospital, Terni, Italy.<br /><searchLink fieldCode="AU" term="%22Manzo+A%22">Manzo A</searchLink>; Thoracic Medical Oncology, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Russo+A%22">Russo A</searchLink>; Medical Oncology Department, Humanitas Istituto Clinico Catanese, Misterbianco, Catania, Italy.; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Rastelli+F%22">Rastelli F</searchLink>; Medical Oncology, AST (Azienda Sanitaria Territoriale) of Ascoli Piceno, Ascoli Piceno, Italy.<br /><searchLink fieldCode="AU" term="%22Bulotta+A%22">Bulotta A</searchLink>; Department of Oncology, Istituto di Ricerca a Carattere Scientifico (IRCCS) San Raffaele Hospital, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Citarella+F%22">Citarella F</searchLink>; Department of Medical Oncology, Campus Bio-Medico University, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Toschi+L%22">Toschi L</searchLink>; IRCCS Humanitas Research Hospital - Medical Oncology, Rozzano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Zoratto+F%22">Zoratto F</searchLink>; Medical Oncology, Santa Maria Goretti Hospital, Latina, Italy.<br /><searchLink fieldCode="AU" term="%22Cortinovis+DL%22">Cortinovis DL</searchLink>; SC Medical Oncology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; Medicine and Surgery Department, University of Milano Bicocca, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Paoloni+F%22">Paoloni F</searchLink>; Oncology Clinic, Universita ` Politecnica Delle Marche, Ospedali Riuniti Di Ancona, Ancona, Italy.<br /><searchLink fieldCode="AU" term="%22Follador+A%22">Follador A</searchLink>; Medical Oncology Unit San Daniele - Tolmezzo, ASUFC Azienda Sanitaria Universitaria Friuli Centrale, Italy.<br /><searchLink fieldCode="AU" term="%22Carta+A%22">Carta A</searchLink>; Pathology and Oncology Unit, Businco Oncological Hospital, Cagliari, Italy.<br /><searchLink fieldCode="AU" term="%22Camerini+A%22">Camerini A</searchLink>; Medical Oncology, Versilia Hospital, Azienda USL Toscana Nord Ovest, Lido di Camaiore, Italy.<br /><searchLink fieldCode="AU" term="%22Salerno+F%22">Salerno F</searchLink>; Department of Oncology, University of Turin, Ordine Mauriziano Hospital, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Silva+RR%22">Silva RR</searchLink>; Department of Oncology, ASUR Marche, Area Vasta 2, Fabriano, Italy.<br /><searchLink fieldCode="AU" term="%22Baldini+E%22">Baldini E</searchLink>; Medical Oncology Unit, San Luca Hospital, Lucca, Italy.<br /><searchLink fieldCode="AU" term="%22Ficorella+C%22">Ficorella C</searchLink>; Department of Biotechnological and Applied Clinical Sciences, St Salvatore Hospital, University of L'Aquila, L'Aquila, Italy.<br /><searchLink fieldCode="AU" term="%22Brighenti+M%22">Brighenti M</searchLink>; Medical Oncology, ASST Cremona, Cremona, Italy.<br /><searchLink fieldCode="AU" term="%22Santoni+M%22">Santoni M</searchLink>; Oncology Unit, Macerata Hospital, Macerata, Italy.<br /><searchLink fieldCode="AU" term="%22Malorgio+F%22">Malorgio F</searchLink>; Department of Oncology, Spirito Santo Hospital, Pescara, Italy.<br /><searchLink fieldCode="AU" term="%22Caminiti+C%22">Caminiti C</searchLink>; Clinical & Epidemiological Research Unit, University Hospital of Parma, Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Puntoni+M%22">Puntoni M</searchLink>; Clinical & Epidemiological Research Unit, University Hospital of Parma, Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Tiseo+M%22">Tiseo M</searchLink>; Medical Oncology Unit, University Hospital of Parma, Parma, Italy.; Department of Medicine and Surgery, University of Parma, Parma, Italy.
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