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A novel hyperactive BCR::ABL1 e6a3 variant confers resistance to combined asciminib plus ponatinib therapy.

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Title: A novel hyperactive BCR::ABL1 e6a3 variant confers resistance to combined asciminib plus ponatinib therapy.
Authors: Nardi V, Schwieterman J, Ansari S, Kincaid Z, Azhar M, Yousuf T, Amir N, Khan A, Kesarwani M, Ryall S, Brunner AM, Capilla Guerra MR, Griffin GK, Nassar N, Daley GQ, Azam M
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2026 Apr 24. Date of Electronic Publication: 2026 Apr 24.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 42078354
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: A novel hyperactive BCR::ABL1 <superscript>e6a3</superscript> variant confers resistance to combined asciminib plus ponatinib therapy.
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  Data: <searchLink fieldCode="AU" term="%22Nardi+V%22">Nardi V</searchLink><br /><searchLink fieldCode="AU" term="%22Schwieterman+J%22">Schwieterman J</searchLink><br /><searchLink fieldCode="AU" term="%22Ansari+S%22">Ansari S</searchLink><br /><searchLink fieldCode="AU" term="%22Kincaid+Z%22">Kincaid Z</searchLink><br /><searchLink fieldCode="AU" term="%22Azhar+M%22">Azhar M</searchLink><br /><searchLink fieldCode="AU" term="%22Yousuf+T%22">Yousuf T</searchLink><br /><searchLink fieldCode="AU" term="%22Amir+N%22">Amir N</searchLink><br /><searchLink fieldCode="AU" term="%22Khan+A%22">Khan A</searchLink><br /><searchLink fieldCode="AU" term="%22Kesarwani+M%22">Kesarwani M</searchLink><br /><searchLink fieldCode="AU" term="%22Ryall+S%22">Ryall S</searchLink><br /><searchLink fieldCode="AU" term="%22Brunner+AM%22">Brunner AM</searchLink><br /><searchLink fieldCode="AU" term="%22Capilla+Guerra+MR%22">Capilla Guerra MR</searchLink><br /><searchLink fieldCode="AU" term="%22Griffin+GK%22">Griffin GK</searchLink><br /><searchLink fieldCode="AU" term="%22Nassar+N%22">Nassar N</searchLink><br /><searchLink fieldCode="AU" term="%22Daley+GQ%22">Daley GQ</searchLink><br /><searchLink fieldCode="AU" term="%22Azam+M%22">Azam M</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22101767986%22">MedRxiv : the preprint server for health sciences</searchLink> [medRxiv] 2026 Apr 24. <i>Date of Electronic Publication: </i>2026 Apr 24.
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  Data: Journal Article; Preprint
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  Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101767986 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>NLM ISO Abbreviation: </i>medRxiv <i>Subsets: </i>PubMed not MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42078354
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      – Type: doi
        Value: 10.64898/2026.04.14.26349982
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      – Code: eng
        Text: English
    Titles:
      – TitleFull: A novel hyperactive BCR::ABL1 e6a3 variant confers resistance to combined asciminib plus ponatinib therapy.
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            NameFull: Nardi V
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            – D: 24
              M: 04
              Text: 2026 Apr 24
              Type: published
              Y: 2026
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            – TitleFull: MedRxiv : the preprint server for health sciences
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