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Histology-Derived Signatures Predict Recurrence Risk and Chemotherapy Benefit in Randomized Trials of Early Breast Cancer.

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Title: Histology-Derived Signatures Predict Recurrence Risk and Chemotherapy Benefit in Randomized Trials of Early Breast Cancer.
Authors: Howard FM; Department of Medicine, University of Chicago, Chicago, IL, USA., Li A; Department of Medicine, University of Chicago, Chicago, IL, USA., Kochanny S; Department of Medicine, University of Chicago, Chicago, IL, USA., Sullivan M; Endeavor Health Cancer Institute, Evanston, IL, USA., Flores EM; Department of Pathology, Ingalls Memorial Hospital, Harvey, IL, USA., Dolezal J; Geisinger Cancer Institute, Danville, PA, USA., Khramtsova G; Department of Medicine, University of Chicago, Chicago, IL, USA., Jain-Liu S; Department of Medicine, University of Chicago, Chicago, IL, USA., Medenwald R; Endeavor Health Cancer Institute, Evanston, IL, USA., Saha P; Endeavor Health Cancer Institute, Evanston, IL, USA., Fan C; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., McCart L; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Watson M; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Teras LR; Department of Population Science, American Cancer Society, Atlanta, GA, USA., Bodelon C; Department of Population Science, American Cancer Society, Atlanta, GA, USA., Patel A; Department of Population Science, American Cancer Society, Atlanta, GA, USA., Symmans WF; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Partridge AH; Dana-Farber Cancer Institute, Boston, MA, USA., Carey L; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Olopade OI; Department of Medicine, University of Chicago, Chicago, IL, USA., Stover D; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Perou C; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Yao K; Endeavor Health Cancer Institute, Evanston, IL, USA., Pearson AT; Department of Medicine, University of Chicago, Chicago, IL, USA., Huo D; Department of Public Health Sciences, University of Chicago, Chicago, IL, USA.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2026 May 05. Date of Electronic Publication: 2026 May 05.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Histology-Derived Signatures Predict Recurrence Risk and Chemotherapy Benefit in Randomized Trials of Early Breast Cancer.
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  Data: <searchLink fieldCode="AU" term="%22Howard+FM%22">Howard FM</searchLink>; Department of Medicine, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Li+A%22">Li A</searchLink>; Department of Medicine, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Kochanny+S%22">Kochanny S</searchLink>; Department of Medicine, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Sullivan+M%22">Sullivan M</searchLink>; Endeavor Health Cancer Institute, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Flores+EM%22">Flores EM</searchLink>; Department of Pathology, Ingalls Memorial Hospital, Harvey, IL, USA.<br /><searchLink fieldCode="AU" term="%22Dolezal+J%22">Dolezal J</searchLink>; Geisinger Cancer Institute, Danville, PA, USA.<br /><searchLink fieldCode="AU" term="%22Khramtsova+G%22">Khramtsova G</searchLink>; Department of Medicine, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Jain-Liu+S%22">Jain-Liu S</searchLink>; Department of Medicine, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Medenwald+R%22">Medenwald R</searchLink>; Endeavor Health Cancer Institute, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Saha+P%22">Saha P</searchLink>; Endeavor Health Cancer Institute, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Fan+C%22">Fan C</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22McCart+L%22">McCart L</searchLink>; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Watson+M%22">Watson M</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Teras+LR%22">Teras LR</searchLink>; Department of Population Science, American Cancer Society, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Bodelon+C%22">Bodelon C</searchLink>; Department of Population Science, American Cancer Society, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Patel+A%22">Patel A</searchLink>; Department of Population Science, American Cancer Society, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Symmans+WF%22">Symmans WF</searchLink>; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Partridge+AH%22">Partridge AH</searchLink>; Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Carey+L%22">Carey L</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Olopade+OI%22">Olopade OI</searchLink>; Department of Medicine, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Stover+D%22">Stover D</searchLink>; The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Perou+C%22">Perou C</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Yao+K%22">Yao K</searchLink>; Endeavor Health Cancer Institute, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Pearson+AT%22">Pearson AT</searchLink>; Department of Medicine, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Huo+D%22">Huo D</searchLink>; Department of Public Health Sciences, University of Chicago, Chicago, IL, USA.
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  Data: <searchLink fieldCode="JN" term="%22101767986%22">MedRxiv : the preprint server for health sciences</searchLink> [medRxiv] 2026 May 05. <i>Date of Electronic Publication: </i>2026 May 05.
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        Value: 10.64898/2026.04.23.26351499
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