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An adipocyte-endothelial framework to identify molecular signatures of metabolic vulnerability in obesity.

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Title: An adipocyte-endothelial framework to identify molecular signatures of metabolic vulnerability in obesity.
Authors: Chaurasiya V; Minerva Foundation Institute for Medical Research, and Doctoral Programme in Clinical Research, University of Helsinki - Helsinki, Finland., Li L; Division of Infection and Immunity, School of Medicine, and Systems Immunity Research Institute, Cardiff University - Cardiff, United Kingdom., Lluch A; Girona Biomedical Research Institute (IDIBGI), and CIBER de la Fisiología de la Obesidad y la Nutrición (CIBEROBN) - Girona, Spain., Fernández-Sánchez A; Girona Biomedical Research Institute (IDIBGI) - Girona, Spain., Harju J; Department of Gastrointestinal Surgery, Abdominal Center, University of Helsinki and Helsinki University Hospital - Helsinki, Finland., Pham DD; Minerva Foundation Institute for Medical Research - Helsinki, Finland., Perttunen S; Minerva Foundation Institute for Medical Research - Helsinki, Finland., Keskitalo S; Molecular Systems Biology Research Group & Proteomics Unit, HiLIFE Helsinki Institute of Life Science, Institute of Biotechnology, University of Helsinki - Helsinki, Finland., Varjosalo M; Molecular Systems Biology Research Group & Proteomics Unit, HiLIFE Helsinki Institute of Life Science, Institute of Biotechnology, University of Helsinki - Helsinki, Finland., Pietiläinen KH; Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, and HealthyWeightHub, Endocrinology, Abdominal Center, Helsinki University Hospital, University of Helsinki - Helsinki, Finland., Haridas PAN; Minerva Foundation Institute for Medical Research - Helsinki, Finland., Moreno-Navarrete JM; Girona Biomedical Research Institute (IDIBGI), CIBER de la Fisiología de la Obesidad y la Nutrición (CIBEROBN), and School of Medicine, University of Girona - Girona, Spain., Rodríguez-Hermosa JI; Girona Biomedical Research Institute (IDIBGI), and School of Medicine, University of Girona - Girona, Spain., Piedrafita-Serra E; Girona Biomedical Research Institute (IDIBGI), and School of Medicine, University of Girona - Girona, Spain., Kar A; Bioinformatics Interdepartmental Program, and Institute for Precision Health, David Geffen School of Medicine, UCLA - Los Angeles, USA., Pajukanta P; Bioinformatics Interdepartmental Program, and Institute for Precision Health, David Geffen School of Medicine at UCLA - Los Angeles, USA., Laakso M; Institute of Clinical Medicine, University of Eastern Finland and Kuopio University Hospital - Kuopio, Finland., Männistö V; Institute of Clinical Medicine, University of Eastern Finland and Kuopio University Hospital - Kuopio, Finland., Pihlajamäki J; Institute of Public Health and Clinical Nutrition, University of Eastern Finland and Kuopio University Hospital - Kuopio, Finland., Kaikkonen MU; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland - Kuopio, Finland., Frühbeck G; Instituto de Investigación Sanitaria de Navarra (IdISNA), Clínica Universidad de Navarra, and CIBER de la Fisiología de la Obesidad y la Nutrición - Pamplona, Spain., Rangel-Zúñiga OA; Maimónides Biomedical Research Institute of Córdoba (IMIBIC), Reina Sofia University Hospital, University of Córdoba, and CIBER de la Fisiología de la Obesidad y la Nutrición - Córdoba, Spain., Tinahones FJ; Instituto de Investigación Biomédica de Málaga (IBIMA), Virgen de la Victoria Hospital, University of Málaga, and CIBER de la Fisiología de la Obesidad y la Nutrición - Málaga, Spain., Dieguez C; Center for Research in Molecular Medicine and Chronic Diseases (CiMUS, University of Santiago de Compostela, Instituto de Investigación Sanitaria, CIBER de la Fisiología de la Obesidad y la Nutrición - Santiago de Compostela, Spain., Burkhardt R; Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg - Regensburg, Germany., Höring M; Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg - Regensburg, Germany., Liebisch G; Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg - Regensburg, Germany., Pörschke J; Institute for Tumor Immunology, Center for Tumor Biology and Immunology, Marburg University - Marburg, Germany., Gómez-Serrano M; Institute for Tumor Immunology, Center for Tumor Biology and Immunology, Marburg University - Marburg, Germany., Graumann J; Institute of Translational Proteomics & Core Facility, Marburg University - Marburg, Germany., Szymanski W; Institute of Translational Proteomics & Core Facility, Marburg University - Marburg, Germany., Fernández-Real JM; Girona Biomedical Research Institute (IDIBGI), CIBER de la Fisiología de la Obesidad y la Nutrición (CIBEROBN), and School of Medicine, University of Girona - Girona, Spain., Zhou Y; Division of Infection and Immunity, School of Medicine, and Systems Immunity Research Institute, Cardiff University - Cardiff, United Kingdom., Olkkonen V; Minerva Foundation Institute for Medical Research, and Department of Anatomy, Faculty of Medicine, University of Helsinki - Helsinki, Finland., Ortega F; Girona Biomedical Research Institute (IDIBGI), and CIBER de la Fisiología de la Obesidad y la Nutrición (CIBEROBN) - Girona, Spain.
Source: Research square [Res Sq] 2026 Apr 23. Date of Electronic Publication: 2026 Apr 23.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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Virtanen Institute for Molecular Sciences, University of Eastern Finland - Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Frühbeck+G%22">Frühbeck G</searchLink>; Instituto de Investigación Sanitaria de Navarra (IdISNA), Clínica Universidad de Navarra, and CIBER de la Fisiología de la Obesidad y la Nutrición - Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Rangel-Zúñiga+OA%22">Rangel-Zúñiga OA</searchLink>; Maimónides Biomedical Research Institute of Córdoba (IMIBIC), Reina Sofia University Hospital, University of Córdoba, and CIBER de la Fisiología de la Obesidad y la Nutrición - Córdoba, Spain.<br /><searchLink fieldCode="AU" term="%22Tinahones+FJ%22">Tinahones FJ</searchLink>; Instituto de Investigación Biomédica de Málaga (IBIMA), Virgen de la Victoria Hospital, University of Málaga, and CIBER de la Fisiología de la Obesidad y la Nutrición - Málaga, Spain.<br /><searchLink fieldCode="AU" term="%22Dieguez+C%22">Dieguez C</searchLink>; Center for Research in Molecular Medicine and Chronic Diseases (CiMUS, University of Santiago de Compostela, Instituto de Investigación Sanitaria, CIBER de la Fisiología de la Obesidad y la Nutrición - Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Burkhardt+R%22">Burkhardt R</searchLink>; Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg - Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Höring+M%22">Höring M</searchLink>; Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg - Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Liebisch+G%22">Liebisch G</searchLink>; Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg - Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Pörschke+J%22">Pörschke J</searchLink>; Institute for Tumor Immunology, Center for Tumor Biology and Immunology, Marburg University - Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Gómez-Serrano+M%22">Gómez-Serrano M</searchLink>; Institute for Tumor Immunology, Center for Tumor Biology and Immunology, Marburg University - Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Graumann+J%22">Graumann J</searchLink>; Institute of Translational Proteomics & Core Facility, Marburg University - Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Szymanski+W%22">Szymanski W</searchLink>; Institute of Translational Proteomics & Core Facility, Marburg University - Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Fernández-Real+JM%22">Fernández-Real JM</searchLink>; Girona Biomedical Research Institute (IDIBGI), CIBER de la Fisiología de la Obesidad y la Nutrición (CIBEROBN), and School of Medicine, University of Girona - Girona, Spain.<br /><searchLink fieldCode="AU" term="%22Zhou+Y%22">Zhou Y</searchLink>; Division of Infection and Immunity, School of Medicine, and Systems Immunity Research Institute, Cardiff University - Cardiff, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Olkkonen+V%22">Olkkonen V</searchLink>; Minerva Foundation Institute for Medical Research, and Department of Anatomy, Faculty of Medicine, University of Helsinki - Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Ortega+F%22">Ortega F</searchLink>; Girona Biomedical Research Institute (IDIBGI), and CIBER de la Fisiología de la Obesidad y la Nutrición (CIBEROBN) - Girona, Spain.
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