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Cysteines are critical determinants of spontaneous and seeded tau aggregation in cells.

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Title: Cysteines are critical determinants of spontaneous and seeded tau aggregation in cells.
Authors: Jayan P; Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; These authors contributed equally., Rastogi S; Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Graduate Program in Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; These authors contributed equally., Bommareddy V; Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Dashnaw CM; Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Vaquer-Alicea J; Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Nguyen BA; Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Saelices L; Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Shahmoradian S; Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., White CL 3rd; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Diamond MI; Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Joachimiak LA; Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Source: Research square [Res Sq] 2026 Apr 23. Date of Electronic Publication: 2026 Apr 23.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Cysteines are critical determinants of spontaneous and seeded tau aggregation in cells.
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  Data: <searchLink fieldCode="AU" term="%22Jayan+P%22">Jayan P</searchLink>; Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; These authors contributed equally.<br /><searchLink fieldCode="AU" term="%22Rastogi+S%22">Rastogi S</searchLink>; Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Graduate Program in Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; These authors contributed equally.<br /><searchLink fieldCode="AU" term="%22Bommareddy+V%22">Bommareddy V</searchLink>; Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.<br /><searchLink fieldCode="AU" term="%22Dashnaw+CM%22">Dashnaw CM</searchLink>; Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.<br /><searchLink fieldCode="AU" term="%22Vaquer-Alicea+J%22">Vaquer-Alicea J</searchLink>; Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+BA%22">Nguyen BA</searchLink>; Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.<br /><searchLink fieldCode="AU" term="%22Saelices+L%22">Saelices L</searchLink>; Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.<br /><searchLink fieldCode="AU" term="%22Shahmoradian+S%22">Shahmoradian S</searchLink>; Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.<br /><searchLink fieldCode="AU" term="%22White+CL+3rd%22">White CL 3rd</searchLink>; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.<br /><searchLink fieldCode="AU" term="%22Diamond+MI%22">Diamond MI</searchLink>; Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.<br /><searchLink fieldCode="AU" term="%22Joachimiak+LA%22">Joachimiak LA</searchLink>; Center for Alzheimer's and Neurodegenerative Diseases, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
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        Value: 10.21203/rs.3.rs-9217102/v1
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              Text: 2026 Apr 23
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