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New approach methodologies (NAMs) to support regulatory assessment of developmental immunotoxicity - a new PARC project.

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Title: New approach methodologies (NAMs) to support regulatory assessment of developmental immunotoxicity - a new PARC project.
Authors: Smith NM; Department of Chemical toxicology, Norwegian Institute of Public Health, Oslo, Norway., de Bruijn VMP; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands., Vandebriel RJ; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands., Hargitai R; Unit of Radiation Medicine, Department of Radiobiology and Radiohygiene, National Centre for Public Health and Pharmacy, Budapest, Hungary., Lumniczky K; Unit of Radiation Medicine, Department of Radiobiology and Radiohygiene, National Centre for Public Health and Pharmacy, Budapest, Hungary., Janssen AWF; Wageningen Food Safety Research (WFSR), Wageningen University and Research, Wageningen, Netherlands., Beekmann K; Wageningen Food Safety Research (WFSR), Wageningen University and Research, Wageningen, Netherlands., Usta B; Wageningen Food Safety Research (WFSR), Wageningen University and Research, Wageningen, Netherlands., Tigges J; IUF - Leibniz Research Institute for Environmental Medicine, Dusseldorf, Germany., Spruck C; IUF - Leibniz Research Institute for Environmental Medicine, Dusseldorf, Germany., Hurem S; Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Aas, Norway., Iulini M; Laboratory of Toxicology and Risk Assessment, Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy., Corsini E; Laboratory of Toxicology and Risk Assessment, Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy., Bado-Nilles A; Institut national de l'environnement industriel et des risques, Verneuil-enHalatte, France., Beaudouin R; Institut national de l'environnement industriel et des risques, Verneuil-enHalatte, France., Katsiadaki I; Centre for Environment, Fisheries and Aquaculture Science (Cefas), Weymouth, United Kingdom., Cano I; Centre for Environment, Fisheries and Aquaculture Science (Cefas), Weymouth, United Kingdom., Sebire M; Centre for Environment, Fisheries and Aquaculture Science (Cefas), Weymouth, United Kingdom., Ayuk HS; Department of Environmental Immunology, Helmholtz Center for Environmental Research- UFZ, Leipzig, Germany., Stojanovska V; Department of Environmental Immunology, Helmholtz Center for Environmental Research- UFZ, Leipzig, Germany.; German Center for Child and Adolescent Health (DZKJ), Leipzig/Dresden, Leipzig, Germany., Zenclussen AC; Department of Environmental Immunology, Helmholtz Center for Environmental Research- UFZ, Leipzig, Germany.; German Center for Child and Adolescent Health (DZKJ), Leipzig/Dresden, Leipzig, Germany.; Perinatal Immunology Research Group, Medical Faculty, Saxonian Incubator for Clinical Translation (SIKT), University of Leipzig, Leipzig, Germany., Blanc EB; Université Paris Cité, INSERM, Health & Functional Exposomics - HealthFex, Paris, France., Kerdine-Römer S; Université Paris-Saclay, Inserm, Inflammation, Microbiome & Immunosurveillance, Orsay, France., Lacerda R; Department of Human Genetics, National Institute of Health Dr Ricardo Jorge, Lisboa, Portugal.; BioISI - Biosystems & Integrative Sciences Institute, University of Lisbon, Faculty of Sciences, Campo Grande, Lisbon, Portugal., Romão L; Department of Human Genetics, National Institute of Health Dr Ricardo Jorge, Lisboa, Portugal.; BioISI - Biosystems & Integrative Sciences Institute, University of Lisbon, Faculty of Sciences, Campo Grande, Lisbon, Portugal., Monfort-Lanzas P; Institute of Medical Biochemistry, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.; Institute of Bioinformatics, Biocenter, Medical University of Innsbruck, Innsbruck, Austria., Gostner JM; Institute of Medical Biochemistry, Biocenter, Medical University of Innsbruck, Innsbruck, Austria., Mposhi A; Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg., Turner JD; Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg., Del Favero G; Institute of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna, Vienna, Austria., Lindeman B; Department of Chemical toxicology, Norwegian Institute of Public Health, Oslo, Norway.
Source: Frontiers in toxicology [Front Toxicol] 2026 Apr 17; Vol. 8, pp. 1740390. Date of Electronic Publication: 2026 Apr 17 (Print Publication: 2026).
Publication Type: Journal Article; Review
Journal Info: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101777990 Publication Model: eCollection Cited Medium: Internet ISSN: 2673-3080 (Electronic) Linking ISSN: 26733080 NLM ISO Abbreviation: Front Toxicol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: New approach methodologies (NAMs) to support regulatory assessment of developmental immunotoxicity - a new PARC project.
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  Data: <searchLink fieldCode="AU" term="%22Smith+NM%22">Smith NM</searchLink>; Department of Chemical toxicology, Norwegian Institute of Public Health, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22de+Bruijn+VMP%22">de Bruijn VMP</searchLink>; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands.<br /><searchLink fieldCode="AU" term="%22Vandebriel+RJ%22">Vandebriel RJ</searchLink>; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands.<br /><searchLink fieldCode="AU" term="%22Hargitai+R%22">Hargitai R</searchLink>; Unit of Radiation Medicine, Department of Radiobiology and Radiohygiene, National Centre for Public Health and Pharmacy, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Lumniczky+K%22">Lumniczky K</searchLink>; Unit of Radiation Medicine, Department of Radiobiology and Radiohygiene, National Centre for Public Health and Pharmacy, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Janssen+AWF%22">Janssen AWF</searchLink>; Wageningen Food Safety Research (WFSR), Wageningen University and Research, Wageningen, Netherlands.<br /><searchLink fieldCode="AU" term="%22Beekmann+K%22">Beekmann K</searchLink>; Wageningen Food Safety Research (WFSR), Wageningen University and Research, Wageningen, Netherlands.<br /><searchLink fieldCode="AU" term="%22Usta+B%22">Usta B</searchLink>; Wageningen Food Safety Research (WFSR), Wageningen University and Research, Wageningen, Netherlands.<br /><searchLink fieldCode="AU" term="%22Tigges+J%22">Tigges J</searchLink>; IUF - Leibniz Research Institute for Environmental Medicine, Dusseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Spruck+C%22">Spruck C</searchLink>; IUF - Leibniz Research Institute for Environmental Medicine, Dusseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Hurem+S%22">Hurem S</searchLink>; Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Aas, Norway.<br /><searchLink fieldCode="AU" term="%22Iulini+M%22">Iulini M</searchLink>; Laboratory of Toxicology and Risk Assessment, Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Corsini+E%22">Corsini E</searchLink>; Laboratory of Toxicology and Risk Assessment, Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Bado-Nilles+A%22">Bado-Nilles A</searchLink>; Institut national de l'environnement industriel et des risques, Verneuil-enHalatte, France.<br /><searchLink fieldCode="AU" term="%22Beaudouin+R%22">Beaudouin R</searchLink>; Institut national de l'environnement industriel et des risques, Verneuil-enHalatte, France.<br /><searchLink fieldCode="AU" term="%22Katsiadaki+I%22">Katsiadaki I</searchLink>; Centre for Environment, Fisheries and Aquaculture Science (Cefas), Weymouth, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Cano+I%22">Cano I</searchLink>; Centre for Environment, Fisheries and Aquaculture Science (Cefas), Weymouth, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Sebire+M%22">Sebire M</searchLink>; Centre for Environment, Fisheries and Aquaculture Science (Cefas), Weymouth, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Ayuk+HS%22">Ayuk HS</searchLink>; Department of Environmental Immunology, Helmholtz Center for Environmental Research- UFZ, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Stojanovska+V%22">Stojanovska V</searchLink>; Department of Environmental Immunology, Helmholtz Center for Environmental Research- UFZ, Leipzig, Germany.; German Center for Child and Adolescent Health (DZKJ), Leipzig/Dresden, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Zenclussen+AC%22">Zenclussen AC</searchLink>; Department of Environmental Immunology, Helmholtz Center for Environmental Research- UFZ, Leipzig, Germany.; German Center for Child and Adolescent Health (DZKJ), Leipzig/Dresden, Leipzig, Germany.; Perinatal Immunology Research Group, Medical Faculty, Saxonian Incubator for Clinical Translation (SIKT), University of Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Blanc+EB%22">Blanc EB</searchLink>; Université Paris Cité, INSERM, Health & Functional Exposomics - HealthFex, Paris, France.<br /><searchLink fieldCode="AU" term="%22Kerdine-Römer+S%22">Kerdine-Römer S</searchLink>; Université Paris-Saclay, Inserm, Inflammation, Microbiome & Immunosurveillance, Orsay, France.<br /><searchLink fieldCode="AU" term="%22Lacerda+R%22">Lacerda R</searchLink>; Department of Human Genetics, National Institute of Health Dr Ricardo Jorge, Lisboa, Portugal.; BioISI - Biosystems & Integrative Sciences Institute, University of Lisbon, Faculty of Sciences, Campo Grande, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Romão+L%22">Romão L</searchLink>; Department of Human Genetics, National Institute of Health Dr Ricardo Jorge, Lisboa, Portugal.; BioISI - Biosystems & Integrative Sciences Institute, University of Lisbon, Faculty of Sciences, Campo Grande, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Monfort-Lanzas+P%22">Monfort-Lanzas P</searchLink>; Institute of Medical Biochemistry, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.; Institute of Bioinformatics, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Gostner+JM%22">Gostner JM</searchLink>; Institute of Medical Biochemistry, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Mposhi+A%22">Mposhi A</searchLink>; Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Turner+JD%22">Turner JD</searchLink>; Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.<br /><searchLink fieldCode="AU" term="%22Del+Favero+G%22">Del Favero G</searchLink>; Institute of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Lindeman+B%22">Lindeman B</searchLink>; Department of Chemical toxicology, Norwegian Institute of Public Health, Oslo, Norway.
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