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Single-cell eQTL mapping reveals convergent glial-neuronal risk architecture in Parkinson's disease.

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Title: Single-cell eQTL mapping reveals convergent glial-neuronal risk architecture in Parkinson's disease.
Authors: Lin Z; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT 06510.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; APDA Center for Parkinson Precision Medicine, Yale, New Haven, CT 06510.; Departments of Neurology, Genetics, Neuroscience, Yale, New Haven, CT 06510., Parker J; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT 06510.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; APDA Center for Parkinson Precision Medicine, Yale, New Haven, CT 06510.; Departments of Neurology, Genetics, Neuroscience, Yale, New Haven, CT 06510., Nithianandam V; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Mathivanan S; Sanford Burnham Prebys Medical Discovery Institute, San Diego, CA 92037., Wang T; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT 06510.; APDA Center for Parkinson Precision Medicine, Yale, New Haven, CT 06510.; School of Computer Science, Northwestern Polytechnical University, Xi'an, Shaanxi, China., Liao Z; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT 06510.; APDA Center for Parkinson Precision Medicine, Yale, New Haven, CT 06510., Simmons SK; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Tuncali I; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT 06510.; APDA Center for Parkinson Precision Medicine, Yale, New Haven, CT 06510., Adiconis X; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Haywood N; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Weykopf B; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT 06510.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; APDA Center for Parkinson Precision Medicine, Yale, New Haven, CT 06510.; Departments of Neurology, Genetics, Neuroscience, Yale, New Haven, CT 06510., Teng X; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT 06510.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; APDA Center for Parkinson Precision Medicine, Yale, New Haven, CT 06510.; Departments of Neurology, Genetics, Neuroscience, Yale, New Haven, CT 06510., Sharma M; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT 06510.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; APDA Center for Parkinson Precision Medicine, Yale, New Haven, CT 06510.; Departments of Neurology, Genetics, Neuroscience, Yale, New Haven, CT 06510., Yuan J; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT 06510.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; APDA Center for Parkinson Precision Medicine, Yale, New Haven, CT 06510.; Departments of Neurology, Genetics, Neuroscience, Yale, New Haven, CT 06510., Baecher-Allan C; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Dong X; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT 06510.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; APDA Center for Parkinson Precision Medicine, Yale, New Haven, CT 06510.; Departments of Neurology, Genetics, Neuroscience, Yale, New Haven, CT 06510.; Computational Biology and Bioinformatics Program, Yale, New Haven, CT 06510., Beach TG; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; Banner Sun Health Research, Sun City, AZ 85351, USA., Serrano GE; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; Banner Sun Health Research, Sun City, AZ 85351, USA., Levin JZ; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Zhang SC; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; Sanford Burnham Prebys Medical Discovery Institute, San Diego, CA 92037., Feany MB; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Scherzer CR; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT 06510.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; APDA Center for Parkinson Precision Medicine, Yale, New Haven, CT 06510.; Departments of Neurology, Genetics, Neuroscience, Yale, New Haven, CT 06510.; Computational Biology and Bioinformatics Program, Yale, New Haven, CT 06510.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Apr 29. Date of Electronic Publication: 2026 Apr 29.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
An: 42079086
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Single-cell eQTL mapping reveals convergent glial-neuronal risk architecture in Parkinson's disease.
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  Data: <searchLink fieldCode="AU" term="%22Lin+Z%22">Lin Z</searchLink>; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT 06510.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; APDA Center for Parkinson Precision Medicine, Yale, New Haven, CT 06510.; Departments of Neurology, Genetics, Neuroscience, Yale, New Haven, CT 06510.<br /><searchLink fieldCode="AU" term="%22Parker+J%22">Parker J</searchLink>; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT 06510.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; APDA Center for Parkinson Precision Medicine, Yale, New Haven, CT 06510.; Departments of Neurology, Genetics, Neuroscience, Yale, New Haven, CT 06510.<br /><searchLink fieldCode="AU" term="%22Nithianandam+V%22">Nithianandam V</searchLink>; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Mathivanan+S%22">Mathivanan S</searchLink>; Sanford Burnham Prebys Medical Discovery Institute, San Diego, CA 92037.<br /><searchLink fieldCode="AU" term="%22Wang+T%22">Wang T</searchLink>; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT 06510.; APDA Center for Parkinson Precision Medicine, Yale, New Haven, CT 06510.; School of Computer Science, Northwestern Polytechnical University, Xi'an, Shaanxi, China.<br /><searchLink fieldCode="AU" term="%22Liao+Z%22">Liao Z</searchLink>; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT 06510.; APDA Center for Parkinson Precision Medicine, Yale, New Haven, CT 06510.<br /><searchLink fieldCode="AU" term="%22Simmons+SK%22">Simmons SK</searchLink>; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Tuncali+I%22">Tuncali I</searchLink>; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT 06510.; APDA Center for Parkinson Precision Medicine, Yale, New Haven, CT 06510.<br /><searchLink fieldCode="AU" term="%22Adiconis+X%22">Adiconis X</searchLink>; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Haywood+N%22">Haywood N</searchLink>; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Weykopf+B%22">Weykopf B</searchLink>; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT 06510.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; APDA Center for Parkinson Precision Medicine, Yale, New Haven, CT 06510.; Departments of Neurology, Genetics, Neuroscience, Yale, New Haven, CT 06510.<br /><searchLink fieldCode="AU" term="%22Teng+X%22">Teng X</searchLink>; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT 06510.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; APDA Center for Parkinson Precision Medicine, Yale, New Haven, CT 06510.; Departments of Neurology, Genetics, Neuroscience, Yale, New Haven, CT 06510.<br /><searchLink fieldCode="AU" term="%22Sharma+M%22">Sharma M</searchLink>; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT 06510.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; APDA Center for Parkinson Precision Medicine, Yale, New Haven, CT 06510.; Departments of Neurology, Genetics, Neuroscience, Yale, New Haven, CT 06510.<br /><searchLink fieldCode="AU" term="%22Yuan+J%22">Yuan J</searchLink>; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT 06510.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; APDA Center for Parkinson Precision Medicine, Yale, New Haven, CT 06510.; Departments of Neurology, Genetics, Neuroscience, Yale, New Haven, CT 06510.<br /><searchLink fieldCode="AU" term="%22Baecher-Allan+C%22">Baecher-Allan C</searchLink>; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Dong+X%22">Dong X</searchLink>; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT 06510.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; APDA Center for Parkinson Precision Medicine, Yale, New Haven, CT 06510.; Departments of Neurology, Genetics, Neuroscience, Yale, New Haven, CT 06510.; Computational Biology and Bioinformatics Program, Yale, New Haven, CT 06510.<br /><searchLink fieldCode="AU" term="%22Beach+TG%22">Beach TG</searchLink>; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; Banner Sun Health Research, Sun City, AZ 85351, USA.<br /><searchLink fieldCode="AU" term="%22Serrano+GE%22">Serrano GE</searchLink>; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; Banner Sun Health Research, Sun City, AZ 85351, USA.<br /><searchLink fieldCode="AU" term="%22Levin+JZ%22">Levin JZ</searchLink>; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+SC%22">Zhang SC</searchLink>; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; Sanford Burnham Prebys Medical Discovery Institute, San Diego, CA 92037.<br /><searchLink fieldCode="AU" term="%22Feany+MB%22">Feany MB</searchLink>; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Scherzer+CR%22">Scherzer CR</searchLink>; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT 06510.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.; APDA Center for Parkinson Precision Medicine, Yale, New Haven, CT 06510.; Departments of Neurology, Genetics, Neuroscience, Yale, New Haven, CT 06510.; Computational Biology and Bioinformatics Program, Yale, New Haven, CT 06510.
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