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Characterization and therapeutic suppression of KEAP1-NRF2-driven resistance to KRAS inhibitors in pancreatic and lung cancer.

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Title: Characterization and therapeutic suppression of KEAP1-NRF2-driven resistance to KRAS inhibitors in pancreatic and lung cancer.
Authors: Chang WH; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Vaughan AJ; Department of Pathology, NYU Langone Health, New York, New York.; Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, New York., Stamey AG; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Mancini M; Department of Pathology, NYU Langone Health, New York, New York.; Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, New York.; Department of Biochemistry, Federal University of São Paulo, São Paulo, Brazil., Hayashi M; Department of Pathology, NYU Langone Health, New York, New York.; Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, New York., Yang R; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Robb R; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Andrussier D; Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, New York., Klomp JA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Waters AM; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Schaefer A; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Wolpin BM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Bryant KL; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Cox AD; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.; Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Simabuco FM; Department of Biochemistry, Federal University of São Paulo, São Paulo, Brazil., Wong KK; Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, New York., Aguirre AJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts.; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts., Stalnecker CA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Papagiannakopoulos T; Department of Pathology, NYU Langone Health, New York, New York.; Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, New York., Der CJ; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Apr 21. Date of Electronic Publication: 2026 Apr 21.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Characterization and therapeutic suppression of KEAP1-NRF2-driven resistance to KRAS inhibitors in pancreatic and lung cancer.
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  Data: <searchLink fieldCode="AU" term="%22Chang+WH%22">Chang WH</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.<br /><searchLink fieldCode="AU" term="%22Vaughan+AJ%22">Vaughan AJ</searchLink>; Department of Pathology, NYU Langone Health, New York, New York.; Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, New York.<br /><searchLink fieldCode="AU" term="%22Stamey+AG%22">Stamey AG</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.<br /><searchLink fieldCode="AU" term="%22Mancini+M%22">Mancini M</searchLink>; Department of Pathology, NYU Langone Health, New York, New York.; Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, New York.; Department of Biochemistry, Federal University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Hayashi+M%22">Hayashi M</searchLink>; Department of Pathology, NYU Langone Health, New York, New York.; Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, New York.<br /><searchLink fieldCode="AU" term="%22Yang+R%22">Yang R</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.<br /><searchLink fieldCode="AU" term="%22Robb+R%22">Robb R</searchLink>; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.<br /><searchLink fieldCode="AU" term="%22Andrussier+D%22">Andrussier D</searchLink>; Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, New York.<br /><searchLink fieldCode="AU" term="%22Klomp+JA%22">Klomp JA</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.<br /><searchLink fieldCode="AU" term="%22Waters+AM%22">Waters AM</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.<br /><searchLink fieldCode="AU" term="%22Schaefer+A%22">Schaefer A</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.<br /><searchLink fieldCode="AU" term="%22Wolpin+BM%22">Wolpin BM</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Bryant+KL%22">Bryant KL</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.<br /><searchLink fieldCode="AU" term="%22Cox+AD%22">Cox AD</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.; Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.<br /><searchLink fieldCode="AU" term="%22Simabuco+FM%22">Simabuco FM</searchLink>; Department of Biochemistry, Federal University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Wong+KK%22">Wong KK</searchLink>; Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, New York.<br /><searchLink fieldCode="AU" term="%22Aguirre+AJ%22">Aguirre AJ</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts.; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Stalnecker+CA%22">Stalnecker CA</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.<br /><searchLink fieldCode="AU" term="%22Papagiannakopoulos+T%22">Papagiannakopoulos T</searchLink>; Department of Pathology, NYU Langone Health, New York, New York.; Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, New York.<br /><searchLink fieldCode="AU" term="%22Der+CJ%22">Der CJ</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
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        Value: 10.64898/2026.04.18.719329
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