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Development of a Fully Non-Viral 1XX-enhanced BCMA CAR-T Cell Therapy for Multiple Myeloma.

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Title: Development of a Fully Non-Viral 1XX-enhanced BCMA CAR-T Cell Therapy for Multiple Myeloma.
Authors: Talbot A; Department of Medicine, University of California San Francisco, CA, USA.; Université de Paris Cité, INSERM UMR1342, Hôpital St-Louis, Paris, France.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA., Li K; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Department of Laboratory Medicine, University of California San Francisco, CA, USA., Lee JHJ; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Department of Laboratory Medicine, University of California San Francisco, CA, USA., Lang S; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA., Liu C; Department of Medicine, University of California San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA., Kalter N; The Institute for Advanced Materials and Nanotechnology, The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan 5290002, Israel., Li Z; Department of Medicine, University of California San Francisco, CA, USA.; Department of Laboratory Medicine, University of California San Francisco, CA, USA., Mortazavi Y; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA., Almudhfar N; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA., Muldoon JJ; Department of Medicine, University of California San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA., Allain V; Department of Medicine, University of California San Francisco, CA, USA.; Université de Paris Cité, INSERM UMR1342, Hôpital St-Louis, Paris, France.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA., Nyberg W; Department of Medicine, University of California San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA., Chung JJ; Department of Medicine, University of California San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA., Wang C; Department of Medicine, University of California San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA., Qi Z; Department of Laboratory Medicine, University of California San Francisco, CA, USA., Krishnappa N; Innovative Genomics Institute, Berkeley, CA, USA., Ha AS; Department of Laboratory Medicine, University of California San Francisco, CA, USA., Kong D; Department of Laboratory Medicine, University of California San Francisco, CA, USA., Houser D; Department of Laboratory Medicine, University of California San Francisco, CA, USA., Paruthiyil S; Department of Laboratory Medicine, University of California San Francisco, CA, USA., Ahmadi M; Thermo Fisher Scientific, Carlsbad, CA, USA., Ji Y; Thermo Fisher Scientific, Carlsbad, CA, USA., Rosenberg M; The Institute for Advanced Materials and Nanotechnology, The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan 5290002, Israel., Acevedo LA; Department of Laboratory Medicine, University of California San Francisco, CA, USA., Liang B; Department of Laboratory Medicine, University of California San Francisco, CA, USA., Briseno K; Department of Laboratory Medicine, University of California San Francisco, CA, USA.; Innovative Genomics Institute, Berkeley, CA, USA., Kwek SS; Department of Medicine, University of California San Francisco, CA, USA., Bachl S; Department of Medicine, University of California San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA., Ching C; Department of Medicine, University of California San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA., Carnevale J; Department of Medicine, University of California San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA.; UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.; Weill Cancer Hub West, Stanford University and University of California, San Francisco, CA, USA., Giannikopoulos P; Department of Laboratory Medicine, University of California San Francisco, CA, USA.; Innovative Genomics Institute, Berkeley, CA, USA., Oh DY; Department of Medicine, University of California San Francisco, CA, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA.; UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA., Marson A; Department of Medicine, University of California San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Innovative Genomics Institute, Berkeley, CA, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA.; UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA., Hendel A; The Institute for Advanced Materials and Nanotechnology, The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan 5290002, Israel., Martin T; Department of Medicine, University of California San Francisco, CA, USA., Eyquem J; Department of Medicine, University of California San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Innovative Genomics Institute, Berkeley, CA, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA.; UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA., Shy BR; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Department of Laboratory Medicine, University of California San Francisco, CA, USA.; UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 May 05. Date of Electronic Publication: 2026 May 05.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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  Data: Development of a Fully Non-Viral 1XX-enhanced BCMA CAR-T Cell Therapy for Multiple Myeloma.
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Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kalter+N%22">Kalter N</searchLink>; The Institute for Advanced Materials and Nanotechnology, The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan 5290002, Israel.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Department of Medicine, University of California San Francisco, CA, USA.; Department of Laboratory Medicine, University of California San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Mortazavi+Y%22">Mortazavi Y</searchLink>; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Almudhfar+N%22">Almudhfar N</searchLink>; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Muldoon+JJ%22">Muldoon JJ</searchLink>; Department of Medicine, University of California San Francisco, CA, USA.; 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Department of Laboratory Medicine, University of California San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Krishnappa+N%22">Krishnappa N</searchLink>; Innovative Genomics Institute, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ha+AS%22">Ha AS</searchLink>; Department of Laboratory Medicine, University of California San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kong+D%22">Kong D</searchLink>; Department of Laboratory Medicine, University of California San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Houser+D%22">Houser D</searchLink>; Department of Laboratory Medicine, University of California San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Paruthiyil+S%22">Paruthiyil S</searchLink>; Department of Laboratory Medicine, University of California San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ahmadi+M%22">Ahmadi M</searchLink>; Thermo Fisher Scientific, Carlsbad, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ji+Y%22">Ji Y</searchLink>; Thermo Fisher Scientific, Carlsbad, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rosenberg+M%22">Rosenberg M</searchLink>; The Institute for Advanced Materials and Nanotechnology, The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan 5290002, Israel.<br /><searchLink fieldCode="AU" term="%22Acevedo+LA%22">Acevedo LA</searchLink>; Department of Laboratory Medicine, University of California San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Liang+B%22">Liang B</searchLink>; Department of Laboratory Medicine, University of California San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Briseno+K%22">Briseno K</searchLink>; Department of Laboratory Medicine, University of California San Francisco, CA, USA.; Innovative Genomics Institute, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kwek+SS%22">Kwek SS</searchLink>; Department of Medicine, University of California San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bachl+S%22">Bachl S</searchLink>; Department of Medicine, University of California San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ching+C%22">Ching C</searchLink>; Department of Medicine, University of California San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Carnevale+J%22">Carnevale J</searchLink>; Department of Medicine, University of California San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA.; UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.; Weill Cancer Hub West, Stanford University and University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Giannikopoulos+P%22">Giannikopoulos P</searchLink>; Department of Laboratory Medicine, University of California San Francisco, CA, USA.; 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The Institute for Advanced Materials and Nanotechnology, The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan 5290002, Israel.<br /><searchLink fieldCode="AU" term="%22Martin+T%22">Martin T</searchLink>; Department of Medicine, University of California San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Eyquem+J%22">Eyquem J</searchLink>; Department of Medicine, University of California San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Innovative Genomics Institute, Berkeley, CA, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA.; UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shy+BR%22">Shy BR</searchLink>; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Department of Laboratory Medicine, University of California San Francisco, CA, USA.; UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.
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