Scalable Synthesis and Biological Evaluation of 3'-Deoxy-3',4'-didehydronucleoside Triphosphates.

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Title: Scalable Synthesis and Biological Evaluation of 3'-Deoxy-3',4'-didehydronucleoside Triphosphates.
Authors: Wood JM; Ferrier Research Institute, Victoria University of Wellington, Wellington 6012, New Zealand.; The Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland 1010, New Zealand., Torres DG; Ferrier Research Institute, Victoria University of Wellington, Wellington 6012, New Zealand., Landaeta Aponte RA; Ferrier Research Institute, Victoria University of Wellington, Wellington 6012, New Zealand., Deshpande S; School of Biological Sciences, The University of Auckland, Auckland 1010, New Zealand., McSweeney AM; Department of Microbiology & Immunology, University of Otago, Dunedin 9054, New Zealand., Shrestha R; Ferrier Research Institute, Victoria University of Wellington, Wellington 6012, New Zealand.; The Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland 1010, New Zealand., Reddy A; Ferrier Research Institute, Victoria University of Wellington, Wellington 6012, New Zealand., Evans GB; Ferrier Research Institute, Victoria University of Wellington, Wellington 6012, New Zealand.; The Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland 1010, New Zealand., Almo SC; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States., Grove TL; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States., Kingston RL; The Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland 1010, New Zealand.; School of Biological Sciences, The University of Auckland, Auckland 1010, New Zealand., Ward VK; The Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland 1010, New Zealand.; Department of Microbiology & Immunology, University of Otago, Dunedin 9054, New Zealand., Harris LD; Ferrier Research Institute, Victoria University of Wellington, Wellington 6012, New Zealand.; The Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland 1010, New Zealand.
Source: The Journal of organic chemistry [J Org Chem] 2026 May 15; Vol. 91 (19), pp. 6744-6750. Date of Electronic Publication: 2026 May 04.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 2985193R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6904 (Electronic) Linking ISSN: 00223263 NLM ISO Abbreviation: J Org Chem Subsets: MEDLINE
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