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Impact of Plasma p-tau181 on Cognition, Motor Phenotypes, and Disease Course in ALS.

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Title: Impact of Plasma p-tau181 on Cognition, Motor Phenotypes, and Disease Course in ALS.
Authors: Kasper E; Department of Neurology, Rostock University Medical Center, Rostock, Germany.; German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Germany., Lehto A; Department of Neurology, Rostock University Medical Center, Rostock, Germany.; German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Germany.; Translational Neurodegeneration Section 'Albrecht Kossel', Department of Neurology, Rostock University Medical Center, Rostock, Germany., Nordmann N; Department of Neurology, Rostock University Medical Center, Rostock, Germany., Peters O; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin-Institute of Psychiatry and Psychotherapy, Berlin, Germany., Hellmann J; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Neurosciences, Charité Universitätsmedizin Berlin, Berlin, Germany.; ECRC Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, Berlin, Germany., Priller J; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Neuropsychiatry and Laboratory of Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, Germany.; Department of Psychiatry and Psychotherapy, School of Medicine and Health, Technical University of Munich, and German Center for Mental Health (DZPG), Munich, Germany.; University of Edinburgh and UK DRI, Edinburgh, UK., Spruth EJ; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Neuropsychiatry and Laboratory of Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, Germany., Petzold GC; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Vascular Neurology, University Hospital Bonn, Bonn, Germany., Vogt I; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Weydt P; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Neurology, University of Bonn, Bonn, Germany., Bernsen S; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Neurology, University of Bonn, Bonn, Germany., Dinter E; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany.; Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Falkenburger B; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany.; Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Günther R; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany.; Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Düzel E; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University, Magdeburg, Germany.; Institute of Cognitive Neuroscience, University College London, London, UK., Glanz W; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University, Magdeburg, Germany., Synofzik M; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Division of Translational Genomics of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Tübingen, Germany., Beichert L; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Division of Translational Genomics of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Tübingen, Germany., Spottke A; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Neurology, University of Bonn, Bonn, Germany., Wagner M; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department for Cognitive Disorders and Old Age Psychiatry, University Hospital Bonn, Bonn, Germany., Brosseron F; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Schmid MC; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Institute for Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, Bonn, Germany., Schneider A; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department for Cognitive Disorders and Old Age Psychiatry, University Hospital Bonn, Bonn, Germany., Teipel S; German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Germany.; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany., Prudlo J; Department of Neurology, Rostock University Medical Center, Rostock, Germany.; German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Germany., Hermann A; German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Germany.; Translational Neurodegeneration Section 'Albrecht Kossel', Department of Neurology, Rostock University Medical Center, Rostock, Germany.
Source: Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2026 May 04. Date of Electronic Publication: 2026 May 04.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Periodicals, Inc on behalf of American Neurological Association Country of Publication: United States NLM ID: 101623278 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2328-9503 (Electronic) Linking ISSN: 23289503 NLM ISO Abbreviation: Ann Clin Transl Neurol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Impact of Plasma p-tau181 on Cognition, Motor Phenotypes, and Disease Course in ALS.
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  Data: <searchLink fieldCode="AU" term="%22Kasper+E%22">Kasper E</searchLink>; Department of Neurology, Rostock University Medical Center, Rostock, Germany.; German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Lehto+A%22">Lehto A</searchLink>; Department of Neurology, Rostock University Medical Center, Rostock, Germany.; German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Germany.; Translational Neurodegeneration Section 'Albrecht Kossel', Department of Neurology, Rostock University Medical Center, Rostock, Germany.<br /><searchLink fieldCode="AU" term="%22Nordmann+N%22">Nordmann N</searchLink>; Department of Neurology, Rostock University Medical Center, Rostock, Germany.<br /><searchLink fieldCode="AU" term="%22Peters+O%22">Peters O</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin-Institute of Psychiatry and Psychotherapy, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Hellmann+J%22">Hellmann J</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Neurosciences, Charité Universitätsmedizin Berlin, Berlin, Germany.; ECRC Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Priller+J%22">Priller J</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Neuropsychiatry and Laboratory of Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, Germany.; Department of Psychiatry and Psychotherapy, School of Medicine and Health, Technical University of Munich, and German Center for Mental Health (DZPG), Munich, Germany.; University of Edinburgh and UK DRI, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Spruth+EJ%22">Spruth EJ</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Neuropsychiatry and Laboratory of Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Petzold+GC%22">Petzold GC</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Vascular Neurology, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Vogt+I%22">Vogt I</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Weydt+P%22">Weydt P</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Neurology, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Bernsen+S%22">Bernsen S</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Neurology, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Dinter+E%22">Dinter E</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany.; Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Falkenburger+B%22">Falkenburger B</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany.; Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Günther+R%22">Günther R</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany.; Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Düzel+E%22">Düzel E</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University, Magdeburg, Germany.; Institute of Cognitive Neuroscience, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Glanz+W%22">Glanz W</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University, Magdeburg, Germany.<br /><searchLink fieldCode="AU" term="%22Synofzik+M%22">Synofzik M</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Division of Translational Genomics of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Beichert+L%22">Beichert L</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Division of Translational Genomics of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Spottke+A%22">Spottke A</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Neurology, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Wagner+M%22">Wagner M</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department for Cognitive Disorders and Old Age Psychiatry, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Brosseron+F%22">Brosseron F</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Schmid+MC%22">Schmid MC</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Institute for Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Schneider+A%22">Schneider A</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department for Cognitive Disorders and Old Age Psychiatry, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Teipel+S%22">Teipel S</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Germany.; Department of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany.<br /><searchLink fieldCode="AU" term="%22Prudlo+J%22">Prudlo J</searchLink>; Department of Neurology, Rostock University Medical Center, Rostock, Germany.; German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Hermann+A%22">Hermann A</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Germany.; Translational Neurodegeneration Section 'Albrecht Kossel', Department of Neurology, Rostock University Medical Center, Rostock, Germany.
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