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Intrathecal Mesenchymal Stem Cells in Progressive Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Trial (SMART-MS).

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Title: Intrathecal Mesenchymal Stem Cells in Progressive Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Trial (SMART-MS).
Authors: Kvistad CE; Department of Neurology, Haukeland University Hospital, Bergen, Norway., Kråkenes T; Department of Neurology, Haukeland University Hospital, Bergen, Norway., Holmøy T; Department of Neurology, Akershus University Hospital, Lørenskog, Norway.; Institute of Clinical Medicine, University of Oslo, Norway., Eidem LE; Research Department, Stavanger University Hospital, Norway., Steffensen L; Department of Neurology, University Hospital of North Norway (UNN), Tromsø, Norway., Wesnes K; Department of Neurology, St. Olavs Hospital, Trondheim, Norway., Rojewski M; Institute of Transfusion Medicine, University of Ulm and Institute of Clinical Transfusion Medicine and Immunogenetics Ulm, Red Cross Blood Transfusion Service Baden-Württemberg-Hessen and University Hospital Ulm, Ulm, Germany., Eichele T; Department of Neurology, Haukeland University Hospital, Bergen, Norway., Wergeland S; Department of Neurology, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Medicine, University of Bergen, Norway., Gavasso S; Department of Neurology, Haukeland University Hospital, Bergen, Norway., Barsnes H; Proteomics Unit, Department of Biomedicine, University of Bergen, Norway.; Computational Biology Unit, Department of Informatics, University of Bergen, Norway., Assmus J; Centre for Clinical Research, Haukeland University Hospital, Bergen, Norway., Al-Sharabi N; Department of Clinical Dentistry, University of Bergen, Norway., Mohamed-Ahmed S; Department of Clinical Dentistry, University of Bergen, Norway., Vrenken H; MS Center, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Amsterdam, the Netherlands; and., Brouwer I; MS Center, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Amsterdam, the Netherlands; and., Mutsaerts HM; MS Center, Amsterdam, the Netherlands., Tranfa M; MS Center, Amsterdam, the Netherlands., Gjerde C; Department of Clinical Dentistry, University of Bergen, Norway., Ytterdal M; Department of Neurology, Haukeland University Hospital, Bergen, Norway., Rødahl E; Department of Clinical Medicine, University of Bergen, Norway.; Department of Ophthalmology, Haukeland University Hospital, Bergen, Norway., Berven FS; Proteomics Unit, Department of Biomedicine, University of Bergen, Norway., Schrezenmeier H; Institute of Transfusion Medicine, University of Ulm and Institute of Clinical Transfusion Medicine and Immunogenetics Ulm, Red Cross Blood Transfusion Service Baden-Württemberg-Hessen and University Hospital Ulm, Ulm, Germany., Mustafa K; Department of Clinical Dentistry, University of Bergen, Norway., Bø L; Department of Neurology, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Medicine, University of Bergen, Norway.
Source: Neurology [Neurology] 2026 May 26; Vol. 106 (10), pp. e214915. Date of Electronic Publication: 2026 May 04.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase II; Clinical Trial, Phase I; Multicenter Study
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0401060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-632X (Electronic) Linking ISSN: 00283878 NLM ISO Abbreviation: Neurology Subsets: MEDLINE
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  Data: Intrathecal Mesenchymal Stem Cells in Progressive Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Trial (SMART-MS).
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  Data: <searchLink fieldCode="AU" term="%22Kvistad+CE%22">Kvistad CE</searchLink>; Department of Neurology, Haukeland University Hospital, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Kråkenes+T%22">Kråkenes T</searchLink>; Department of Neurology, Haukeland University Hospital, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Holmøy+T%22">Holmøy T</searchLink>; Department of Neurology, Akershus University Hospital, Lørenskog, Norway.; Institute of Clinical Medicine, University of Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Eidem+LE%22">Eidem LE</searchLink>; Research Department, Stavanger University Hospital, Norway.<br /><searchLink fieldCode="AU" term="%22Steffensen+L%22">Steffensen L</searchLink>; Department of Neurology, University Hospital of North Norway (UNN), Tromsø, Norway.<br /><searchLink fieldCode="AU" term="%22Wesnes+K%22">Wesnes K</searchLink>; Department of Neurology, St. Olavs Hospital, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Rojewski+M%22">Rojewski M</searchLink>; Institute of Transfusion Medicine, University of Ulm and Institute of Clinical Transfusion Medicine and Immunogenetics Ulm, Red Cross Blood Transfusion Service Baden-Württemberg-Hessen and University Hospital Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Eichele+T%22">Eichele T</searchLink>; Department of Neurology, Haukeland University Hospital, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Wergeland+S%22">Wergeland S</searchLink>; Department of Neurology, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Medicine, University of Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Gavasso+S%22">Gavasso S</searchLink>; Department of Neurology, Haukeland University Hospital, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Barsnes+H%22">Barsnes H</searchLink>; Proteomics Unit, Department of Biomedicine, University of Bergen, Norway.; Computational Biology Unit, Department of Informatics, University of Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Assmus+J%22">Assmus J</searchLink>; Centre for Clinical Research, Haukeland University Hospital, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Al-Sharabi+N%22">Al-Sharabi N</searchLink>; Department of Clinical Dentistry, University of Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Mohamed-Ahmed+S%22">Mohamed-Ahmed S</searchLink>; Department of Clinical Dentistry, University of Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Vrenken+H%22">Vrenken H</searchLink>; MS Center, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Amsterdam, the Netherlands; and.<br /><searchLink fieldCode="AU" term="%22Brouwer+I%22">Brouwer I</searchLink>; MS Center, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Amsterdam, the Netherlands; and.<br /><searchLink fieldCode="AU" term="%22Mutsaerts+HM%22">Mutsaerts HM</searchLink>; MS Center, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Tranfa+M%22">Tranfa M</searchLink>; MS Center, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Gjerde+C%22">Gjerde C</searchLink>; Department of Clinical Dentistry, University of Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Ytterdal+M%22">Ytterdal M</searchLink>; Department of Neurology, Haukeland University Hospital, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Rødahl+E%22">Rødahl E</searchLink>; Department of Clinical Medicine, University of Bergen, Norway.; Department of Ophthalmology, Haukeland University Hospital, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Berven+FS%22">Berven FS</searchLink>; Proteomics Unit, Department of Biomedicine, University of Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Schrezenmeier+H%22">Schrezenmeier H</searchLink>; Institute of Transfusion Medicine, University of Ulm and Institute of Clinical Transfusion Medicine and Immunogenetics Ulm, Red Cross Blood Transfusion Service Baden-Württemberg-Hessen and University Hospital Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Mustafa+K%22">Mustafa K</searchLink>; Department of Clinical Dentistry, University of Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Bø+L%22">Bø L</searchLink>; Department of Neurology, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Medicine, University of Bergen, Norway.
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  Data: <searchLink fieldCode="JN" term="%220401060%22">Neurology</searchLink> [Neurology] 2026 May 26; Vol. 106 (10), pp. e214915. <i>Date of Electronic Publication: </i>2026 May 04.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Lippincott+Williams+%26+Wilkins%22">Lippincott Williams & Wilkins </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0401060 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1526-632X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200283878%22">00283878 </searchLink><i>NLM ISO Abbreviation: </i>Neurology <i>Subsets: </i>MEDLINE
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