View in EDS

Loss of the E3 ubiquitin ligase MARCHF6 alters hepatic lipid metabolism and drives spontaneous hepatosteatosis.

Saved in:
Bibliographic Details
Title: Loss of the E3 ubiquitin ligase MARCHF6 alters hepatic lipid metabolism and drives spontaneous hepatosteatosis.
Authors: Sachdev V; Department of Medical Biochemistry, Amsterdam UMC location AMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Gastroenterology, Endocrinology, and Metabolism Institute, Amsterdam UMC, the Netherlands; Amsterdam Cardiovascular Sciences Institute, Amsterdam UMC, the Netherlands., van Loon NM; Department of Medical Biochemistry, Amsterdam UMC location AMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Gastroenterology, Endocrinology, and Metabolism Institute, Amsterdam UMC, the Netherlands; Amsterdam Cardiovascular Sciences Institute, Amsterdam UMC, the Netherlands., Kingma J; Department of Medical Biochemistry, Amsterdam UMC location AMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Gastroenterology, Endocrinology, and Metabolism Institute, Amsterdam UMC, the Netherlands; Amsterdam Cardiovascular Sciences Institute, Amsterdam UMC, the Netherlands., Ottenhoff R; Department of Medical Biochemistry, Amsterdam UMC location AMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Gastroenterology, Endocrinology, and Metabolism Institute, Amsterdam UMC, the Netherlands; Amsterdam Cardiovascular Sciences Institute, Amsterdam UMC, the Netherlands., Tan JME; Department of Medical Biochemistry, Amsterdam UMC location AMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Gastroenterology, Endocrinology, and Metabolism Institute, Amsterdam UMC, the Netherlands; Amsterdam Cardiovascular Sciences Institute, Amsterdam UMC, the Netherlands; Department of Physiology, Amsterdam UMC location VUMC, Free University Amsterdam, Amsterdam, the Netherlands., van den Berg M; Department of Medical Biochemistry, Amsterdam UMC location AMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Gastroenterology, Endocrinology, and Metabolism Institute, Amsterdam UMC, the Netherlands; Amsterdam Cardiovascular Sciences Institute, Amsterdam UMC, the Netherlands., Duijst S; Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC location AMC, University of Amsterdam, Amsterdam, the Netherlands., Jongejan A; Bioinformatics Laboratory, Department of Epidemiology & Data Science, Amsterdam UMC location AMC, Amsterdam, the Netherlands., Levels JHM; Department of Experimental Vascular Medicine, Amsterdam UMC location AMC, University of Amsterdam, Amsterdam, the Netherlands., Rensen PCN; Department of Medicine, Division of Endocrinology & Einthoven Laboratory for Experimental Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, the Netherlands., Kooijman S; Department of Medicine, Division of Endocrinology & Einthoven Laboratory for Experimental Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, the Netherlands., de Boer JF; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Kuipers F; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; European Research Institute for the Biology of Ageing (ERIBA), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Kuentzel KB; Gottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria., Kratky D; Gottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria; BioTechMed-Graz, Graz, Austria., Kwon Y; European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Zeigerer A; European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Institute for Diabetes and Cancer, Helmholtz Center Munich, Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, Heidelberg University Hospital, Heidelberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany., Hendrix S; Department of Medical Biochemistry, Amsterdam UMC location AMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Gastroenterology, Endocrinology, and Metabolism Institute, Amsterdam UMC, the Netherlands; Amsterdam Cardiovascular Sciences Institute, Amsterdam UMC, the Netherlands. Electronic address: s.hendrix@amsterdamumc.nl., Zelcer N; Department of Medical Biochemistry, Amsterdam UMC location AMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Gastroenterology, Endocrinology, and Metabolism Institute, Amsterdam UMC, the Netherlands; Amsterdam Cardiovascular Sciences Institute, Amsterdam UMC, the Netherlands. Electronic address: n.zelcer@amsterdamumc.nl.
Source: Molecular metabolism [Mol Metab] 2026 Jun; Vol. 108, pp. 102379. Date of Electronic Publication: 2026 May 02.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-8778 (Electronic) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 42082151
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Loss of the E3 ubiquitin ligase MARCHF6 alters hepatic lipid metabolism and drives spontaneous hepatosteatosis.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Sachdev+V%22">Sachdev V</searchLink>; Department of Medical Biochemistry, Amsterdam UMC location AMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Gastroenterology, Endocrinology, and Metabolism Institute, Amsterdam UMC, the Netherlands; Amsterdam Cardiovascular Sciences Institute, Amsterdam UMC, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Loon+NM%22">van Loon NM</searchLink>; Department of Medical Biochemistry, Amsterdam UMC location AMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Gastroenterology, Endocrinology, and Metabolism Institute, Amsterdam UMC, the Netherlands; Amsterdam Cardiovascular Sciences Institute, Amsterdam UMC, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Kingma+J%22">Kingma J</searchLink>; Department of Medical Biochemistry, Amsterdam UMC location AMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Gastroenterology, Endocrinology, and Metabolism Institute, Amsterdam UMC, the Netherlands; Amsterdam Cardiovascular Sciences Institute, Amsterdam UMC, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Ottenhoff+R%22">Ottenhoff R</searchLink>; Department of Medical Biochemistry, Amsterdam UMC location AMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Gastroenterology, Endocrinology, and Metabolism Institute, Amsterdam UMC, the Netherlands; Amsterdam Cardiovascular Sciences Institute, Amsterdam UMC, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Tan+JME%22">Tan JME</searchLink>; Department of Medical Biochemistry, Amsterdam UMC location AMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Gastroenterology, Endocrinology, and Metabolism Institute, Amsterdam UMC, the Netherlands; Amsterdam Cardiovascular Sciences Institute, Amsterdam UMC, the Netherlands; Department of Physiology, Amsterdam UMC location VUMC, Free University Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+den+Berg+M%22">van den Berg M</searchLink>; Department of Medical Biochemistry, Amsterdam UMC location AMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Gastroenterology, Endocrinology, and Metabolism Institute, Amsterdam UMC, the Netherlands; Amsterdam Cardiovascular Sciences Institute, Amsterdam UMC, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Duijst+S%22">Duijst S</searchLink>; Tytgat Institute for Liver and Intestinal Research, Amsterdam UMC location AMC, University of Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Jongejan+A%22">Jongejan A</searchLink>; Bioinformatics Laboratory, Department of Epidemiology & Data Science, Amsterdam UMC location AMC, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Levels+JHM%22">Levels JHM</searchLink>; Department of Experimental Vascular Medicine, Amsterdam UMC location AMC, University of Amsterdam, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Rensen+PCN%22">Rensen PCN</searchLink>; Department of Medicine, Division of Endocrinology & Einthoven Laboratory for Experimental Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Kooijman+S%22">Kooijman S</searchLink>; Department of Medicine, Division of Endocrinology & Einthoven Laboratory for Experimental Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Boer+JF%22">de Boer JF</searchLink>; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Kuipers+F%22">Kuipers F</searchLink>; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; European Research Institute for the Biology of Ageing (ERIBA), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Kuentzel+KB%22">Kuentzel KB</searchLink>; Gottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Kratky+D%22">Kratky D</searchLink>; Gottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria; BioTechMed-Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Kwon+Y%22">Kwon Y</searchLink>; European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Zeigerer+A%22">Zeigerer A</searchLink>; European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Institute for Diabetes and Cancer, Helmholtz Center Munich, Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, Heidelberg University Hospital, Heidelberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hendrix+S%22">Hendrix S</searchLink>; Department of Medical Biochemistry, Amsterdam UMC location AMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Gastroenterology, Endocrinology, and Metabolism Institute, Amsterdam UMC, the Netherlands; Amsterdam Cardiovascular Sciences Institute, Amsterdam UMC, the Netherlands. Electronic address: s.hendrix@amsterdamumc.nl.<br /><searchLink fieldCode="AU" term="%22Zelcer+N%22">Zelcer N</searchLink>; Department of Medical Biochemistry, Amsterdam UMC location AMC, University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Gastroenterology, Endocrinology, and Metabolism Institute, Amsterdam UMC, the Netherlands; Amsterdam Cardiovascular Sciences Institute, Amsterdam UMC, the Netherlands. Electronic address: n.zelcer@amsterdamumc.nl.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101605730%22">Molecular metabolism</searchLink> [Mol Metab] 2026 Jun; Vol. 108, pp. 102379. <i>Date of Electronic Publication: </i>2026 May 02.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+GmbH%22">Elsevier GmbH </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>101605730 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2212-8778 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2222128778%22">22128778 </searchLink><i>NLM ISO Abbreviation: </i>Mol Metab <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42082151
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.molmet.2026.102379
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 102379
    Titles:
      – TitleFull: Loss of the E3 ubiquitin ligase MARCHF6 alters hepatic lipid metabolism and drives spontaneous hepatosteatosis.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Sachdev V
      – PersonEntity:
          Name:
            NameFull: van Loon NM
      – PersonEntity:
          Name:
            NameFull: Kingma J
      – PersonEntity:
          Name:
            NameFull: Ottenhoff R
      – PersonEntity:
          Name:
            NameFull: Tan JME
      – PersonEntity:
          Name:
            NameFull: van den Berg M
      – PersonEntity:
          Name:
            NameFull: Duijst S
      – PersonEntity:
          Name:
            NameFull: Jongejan A
      – PersonEntity:
          Name:
            NameFull: Levels JHM
      – PersonEntity:
          Name:
            NameFull: Rensen PCN
      – PersonEntity:
          Name:
            NameFull: Kooijman S
      – PersonEntity:
          Name:
            NameFull: de Boer JF
      – PersonEntity:
          Name:
            NameFull: Kuipers F
      – PersonEntity:
          Name:
            NameFull: Kuentzel KB
      – PersonEntity:
          Name:
            NameFull: Kratky D
      – PersonEntity:
          Name:
            NameFull: Kwon Y
      – PersonEntity:
          Name:
            NameFull: Zeigerer A
      – PersonEntity:
          Name:
            NameFull: Hendrix S
      – PersonEntity:
          Name:
            NameFull: Zelcer N
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: 2026 Jun
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2212-8778
          Numbering:
            – Type: volume
              Value: 108
          Titles:
            – TitleFull: Molecular metabolism
              Type: main
ResultId 1