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Emergence of specific binding and catalysis from a designed generalist binding protein.

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Title: Emergence of specific binding and catalysis from a designed generalist binding protein.
Authors: Chen Y; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.; Cardiovascular Research Institute, University of California, San Francisco, CA, USA., Bhattacharya S; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.; Cardiovascular Research Institute, University of California, San Francisco, CA, USA., Bergmann L; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA., Correy GJ; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA., Tan SK; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.; Cardiovascular Research Institute, University of California, San Francisco, CA, USA., Hou K; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.; Cardiovascular Research Institute, University of California, San Francisco, CA, USA., Biel JT; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA., Lu L; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.; Cardiovascular Research Institute, University of California, San Francisco, CA, USA., Bakanas I; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.; Cardiovascular Research Institute, University of California, San Francisco, CA, USA., Gestwicki JE; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.; Institute for Neurodegenerative Diseases, University of California, San Francisco, CA, USA., Volkov AN; VIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnologie (VIB), Brussels, Belgium.; Jean Jeener NMR Centre, Vrije Universiteit Brussel (VUB), Brussels, Belgium., Korendovych IV; Department of Chemistry and Biochemistry, Baylor University, Waco, TX, USA., Polizzi NF; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Fraser JS; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA. jfraser@fraserlab.com., DeGrado WF; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA. bill.degrado@ucsf.edu.; Cardiovascular Research Institute, University of California, San Francisco, CA, USA. bill.degrado@ucsf.edu.; Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai, Japan. bill.degrado@ucsf.edu.
Source: Nature chemistry [Nat Chem] 2026 Jul; Vol. 18 (7), pp. 1334-1344. Date of Electronic Publication: 2026 May 04.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101499734 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1755-4349 (Electronic) Linking ISSN: 17554330 NLM ISO Abbreviation: Nat Chem Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.; Cardiovascular Research Institute, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bhattacharya+S%22">Bhattacharya S</searchLink>; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.; Cardiovascular Research Institute, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bergmann+L%22">Bergmann L</searchLink>; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Correy+GJ%22">Correy GJ</searchLink>; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tan+SK%22">Tan SK</searchLink>; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.; Cardiovascular Research Institute, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hou+K%22">Hou K</searchLink>; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.; Cardiovascular Research Institute, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Biel+JT%22">Biel JT</searchLink>; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lu+L%22">Lu L</searchLink>; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.; Cardiovascular Research Institute, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bakanas+I%22">Bakanas I</searchLink>; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.; Cardiovascular Research Institute, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gestwicki+JE%22">Gestwicki JE</searchLink>; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.; Institute for Neurodegenerative Diseases, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Volkov+AN%22">Volkov AN</searchLink>; VIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnologie (VIB), Brussels, Belgium.; Jean Jeener NMR Centre, Vrije Universiteit Brussel (VUB), Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Korendovych+IV%22">Korendovych IV</searchLink>; Department of Chemistry and Biochemistry, Baylor University, Waco, TX, USA.<br /><searchLink fieldCode="AU" term="%22Polizzi+NF%22">Polizzi NF</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fraser+JS%22">Fraser JS</searchLink>; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA. jfraser@fraserlab.com.<br /><searchLink fieldCode="AU" term="%22DeGrado+WF%22">DeGrado WF</searchLink>; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA. bill.degrado@ucsf.edu.; Cardiovascular Research Institute, University of California, San Francisco, CA, USA. bill.degrado@ucsf.edu.; Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai, Japan. bill.degrado@ucsf.edu.
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  Data: <searchLink fieldCode="JN" term="%22101499734%22">Nature chemistry</searchLink> [Nat Chem] 2026 Jul; Vol. 18 (7), pp. 1334-1344. <i>Date of Electronic Publication: </i>2026 May 04.
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