Emergence of specific binding and catalysis from a designed generalist binding protein.
Saved in:
| Title: | Emergence of specific binding and catalysis from a designed generalist binding protein. |
|---|---|
| Authors: | Chen Y; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.; Cardiovascular Research Institute, University of California, San Francisco, CA, USA., Bhattacharya S; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.; Cardiovascular Research Institute, University of California, San Francisco, CA, USA., Bergmann L; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA., Correy GJ; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA., Tan SK; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.; Cardiovascular Research Institute, University of California, San Francisco, CA, USA., Hou K; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.; Cardiovascular Research Institute, University of California, San Francisco, CA, USA., Biel JT; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA., Lu L; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.; Cardiovascular Research Institute, University of California, San Francisco, CA, USA., Bakanas I; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.; Cardiovascular Research Institute, University of California, San Francisco, CA, USA., Gestwicki JE; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.; Institute for Neurodegenerative Diseases, University of California, San Francisco, CA, USA., Volkov AN; VIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnologie (VIB), Brussels, Belgium.; Jean Jeener NMR Centre, Vrije Universiteit Brussel (VUB), Brussels, Belgium., Korendovych IV; Department of Chemistry and Biochemistry, Baylor University, Waco, TX, USA., Polizzi NF; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Fraser JS; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA. jfraser@fraserlab.com., DeGrado WF; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA. bill.degrado@ucsf.edu.; Cardiovascular Research Institute, University of California, San Francisco, CA, USA. bill.degrado@ucsf.edu.; Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai, Japan. bill.degrado@ucsf.edu. |
| Source: | Nature chemistry [Nat Chem] 2026 Jul; Vol. 18 (7), pp. 1334-1344. Date of Electronic Publication: 2026 May 04. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101499734 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1755-4349 (Electronic) Linking ISSN: 17554330 NLM ISO Abbreviation: Nat Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
Be the first to leave a comment!
