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Gastric pH-induced liquid-liquid phase separation between lactoferrin and osteopontin protects against proteolysis and modulates intestinal uptake.

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Title: Gastric pH-induced liquid-liquid phase separation between lactoferrin and osteopontin protects against proteolysis and modulates intestinal uptake.
Authors: Liu L; Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, Zhejiang 310052, China. Electronic address: lanliu@zju.edu.cn., Lin C; Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, Zhejiang 310052, China., Zheng M; College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China., Tu X; College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China., Yu Y; College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China., Song Z; Department of Nutrition, University of California, Davis, CA 95616, USA., Qi G; Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, Zhejiang 310052, China., Li S; College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China., Yang M; College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China; Zhejiang Provincial Key Laboratory of Silk and Silk Protein New Materials, Institute of Applied Bioresource Research, Zhejiang University, Hangzhou, Zhejiang 310058, China., Lönnerdal B; Department of Nutrition, University of California, Davis, CA 95616, USA., Shuai Y; College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China; Zhejiang Provincial Key Laboratory of Silk and Silk Protein New Materials, Institute of Applied Bioresource Research, Zhejiang University, Hangzhou, Zhejiang 310058, China. Electronic address: shuaiy@zju.edu.cn.
Source: Food research international (Ottawa, Ont.) [Food Res Int] 2026 Jul 01; Vol. 235, pp. 119117. Date of Electronic Publication: 2026 Apr 14.
Publication Type: Journal Article
Journal Info: Publisher: Published on behalf of the Canadian Institute of Food Science and Technology by Elsevier Applied Science Country of Publication: Canada NLM ID: 9210143 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7145 (Electronic) Linking ISSN: 09639969 NLM ISO Abbreviation: Food Res Int Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Gastric pH-induced liquid-liquid phase separation between lactoferrin and osteopontin protects against proteolysis and modulates intestinal uptake.
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  Data: <searchLink fieldCode="AU" term="%22Liu+L%22">Liu L</searchLink>; Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, Zhejiang 310052, China. Electronic address: lanliu@zju.edu.cn.<br /><searchLink fieldCode="AU" term="%22Lin+C%22">Lin C</searchLink>; Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, Zhejiang 310052, China.<br /><searchLink fieldCode="AU" term="%22Zheng+M%22">Zheng M</searchLink>; College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China.<br /><searchLink fieldCode="AU" term="%22Tu+X%22">Tu X</searchLink>; College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China.<br /><searchLink fieldCode="AU" term="%22Yu+Y%22">Yu Y</searchLink>; College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China.<br /><searchLink fieldCode="AU" term="%22Song+Z%22">Song Z</searchLink>; Department of Nutrition, University of California, Davis, CA 95616, USA.<br /><searchLink fieldCode="AU" term="%22Qi+G%22">Qi G</searchLink>; Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, Zhejiang 310052, China.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China.<br /><searchLink fieldCode="AU" term="%22Yang+M%22">Yang M</searchLink>; College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China; Zhejiang Provincial Key Laboratory of Silk and Silk Protein New Materials, Institute of Applied Bioresource Research, Zhejiang University, Hangzhou, Zhejiang 310058, China.<br /><searchLink fieldCode="AU" term="%22Lönnerdal+B%22">Lönnerdal B</searchLink>; Department of Nutrition, University of California, Davis, CA 95616, USA.<br /><searchLink fieldCode="AU" term="%22Shuai+Y%22">Shuai Y</searchLink>; College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China; Zhejiang Provincial Key Laboratory of Silk and Silk Protein New Materials, Institute of Applied Bioresource Research, Zhejiang University, Hangzhou, Zhejiang 310058, China. Electronic address: shuaiy@zju.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%229210143%22">Food research international (Ottawa, Ont.)</searchLink> [Food Res Int] 2026 Jul 01; Vol. 235, pp. 119117. <i>Date of Electronic Publication: </i>2026 Apr 14.
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        Value: 10.1016/j.foodres.2026.119117
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              Text: 2026 Jul 01
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