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Annexin A1 alleviates heatstroke by inhibiting RIPK3/MLKL-mediated necroptosis through an FPR2-dependent pathway in male mice.

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Title: Annexin A1 alleviates heatstroke by inhibiting RIPK3/MLKL-mediated necroptosis through an FPR2-dependent pathway in male mice.
Authors: Feng B; Department of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, China.; Precision Anaesthesiology Key Laboratory of Zhejiang Province, Wenzhou Medical University, Wenzhou, China., Li H; Department of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, China.; Precision Anaesthesiology Key Laboratory of Zhejiang Province, Wenzhou Medical University, Wenzhou, China., Pan XD; Department of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, China.; Precision Anaesthesiology Key Laboratory of Zhejiang Province, Wenzhou Medical University, Wenzhou, China.; Department of Emergency Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China., Zhang WY; Department of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, China.; Precision Anaesthesiology Key Laboratory of Zhejiang Province, Wenzhou Medical University, Wenzhou, China., Li XY; Department of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, China.; Precision Anaesthesiology Key Laboratory of Zhejiang Province, Wenzhou Medical University, Wenzhou, China., Jiang YT; Department of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, China.; Precision Anaesthesiology Key Laboratory of Zhejiang Province, Wenzhou Medical University, Wenzhou, China., Liu LF; Department of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, China.; Precision Anaesthesiology Key Laboratory of Zhejiang Province, Wenzhou Medical University, Wenzhou, China., Bhandari S; Department of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, China.; Precision Anaesthesiology Key Laboratory of Zhejiang Province, Wenzhou Medical University, Wenzhou, China., Luo J; Department of Pharmacy, Taizhou Women and Children's Hospital of Wenzhou Medical University, Taizhou, China., Weng HX; Department of Critical Care Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Ruian, China., Chen J; Department of Emergency, The Third Affiliated Hospital of Wenzhou Medical University, Ruian, China., Ding YJ; Department of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, China.; Precision Anaesthesiology Key Laboratory of Zhejiang Province, Wenzhou Medical University, Wenzhou, China., Chen T; Department of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, China.; Precision Anaesthesiology Key Laboratory of Zhejiang Province, Wenzhou Medical University, Wenzhou, China., Jin HX; Department of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, China.; Precision Anaesthesiology Key Laboratory of Zhejiang Province, Wenzhou Medical University, Wenzhou, China., Zhu XY; Department of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, China.; Precision Anaesthesiology Key Laboratory of Zhejiang Province, Wenzhou Medical University, Wenzhou, China., Xin XM; Department of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, China.; Precision Anaesthesiology Key Laboratory of Zhejiang Province, Wenzhou Medical University, Wenzhou, China., Gong YQ; Department of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, China.; Precision Anaesthesiology Key Laboratory of Zhejiang Province, Wenzhou Medical University, Wenzhou, China., Jin SW; Department of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, China.; Precision Anaesthesiology Key Laboratory of Zhejiang Province, Wenzhou Medical University, Wenzhou, China., Hao Y; Department of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, China.; Precision Anaesthesiology Key Laboratory of Zhejiang Province, Wenzhou Medical University, Wenzhou, China.; Wenzhou Key Laboratory of Precision General Practice and Health Management, Wenzhou, China.
Source: British journal of pharmacology [Br J Pharmacol] 2026 Aug; Vol. 183 (16), pp. 4698-4714. Date of Electronic Publication: 2026 May 04.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Annexin A1 alleviates heatstroke by inhibiting RIPK3/MLKL-mediated necroptosis through an FPR2-dependent pathway in male mice.
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  Data: <searchLink fieldCode="AU" term="%22Feng+B%22">Feng B</searchLink>; Department of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, China.; Precision Anaesthesiology Key Laboratory of Zhejiang Province, Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; Department of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, China.; Precision Anaesthesiology Key Laboratory of Zhejiang Province, Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Pan+XD%22">Pan XD</searchLink>; Department of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, China.; Precision Anaesthesiology Key Laboratory of Zhejiang Province, Wenzhou Medical University, Wenzhou, China.; Department of Emergency Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhang+WY%22">Zhang WY</searchLink>; Department of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, China.; Precision Anaesthesiology Key Laboratory of Zhejiang Province, Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Li+XY%22">Li XY</searchLink>; Department of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, China.; Precision Anaesthesiology Key Laboratory of Zhejiang Province, Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Jiang+YT%22">Jiang YT</searchLink>; Department of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, China.; Precision Anaesthesiology Key Laboratory of Zhejiang Province, Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Liu+LF%22">Liu LF</searchLink>; Department of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, China.; Precision Anaesthesiology Key Laboratory of Zhejiang Province, Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Bhandari+S%22">Bhandari S</searchLink>; Department of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, China.; Precision Anaesthesiology Key Laboratory of Zhejiang Province, Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Luo+J%22">Luo J</searchLink>; Department of Pharmacy, Taizhou Women and Children's Hospital of Wenzhou Medical University, Taizhou, China.<br /><searchLink fieldCode="AU" term="%22Weng+HX%22">Weng HX</searchLink>; Department of Critical Care Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Ruian, China.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Department of Emergency, The Third Affiliated Hospital of Wenzhou Medical University, Ruian, China.<br /><searchLink fieldCode="AU" term="%22Ding+YJ%22">Ding YJ</searchLink>; Department of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, China.; Precision Anaesthesiology Key Laboratory of Zhejiang Province, Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Chen+T%22">Chen T</searchLink>; Department of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, China.; Precision Anaesthesiology Key Laboratory of Zhejiang Province, Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Jin+HX%22">Jin HX</searchLink>; Department of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, China.; Precision Anaesthesiology Key Laboratory of Zhejiang Province, Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhu+XY%22">Zhu XY</searchLink>; Department of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, China.; Precision Anaesthesiology Key Laboratory of Zhejiang Province, Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Xin+XM%22">Xin XM</searchLink>; Department of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, China.; Precision Anaesthesiology Key Laboratory of Zhejiang Province, Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Gong+YQ%22">Gong YQ</searchLink>; Department of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, China.; Precision Anaesthesiology Key Laboratory of Zhejiang Province, Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Jin+SW%22">Jin SW</searchLink>; Department of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, China.; Precision Anaesthesiology Key Laboratory of Zhejiang Province, Wenzhou Medical University, Wenzhou, China.<br /><searchLink fieldCode="AU" term="%22Hao+Y%22">Hao Y</searchLink>; Department of Anaesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, China.; Precision Anaesthesiology Key Laboratory of Zhejiang Province, Wenzhou Medical University, Wenzhou, China.; Wenzhou Key Laboratory of Precision General Practice and Health Management, Wenzhou, China.
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  Data: <searchLink fieldCode="JN" term="%227502536%22">British journal of pharmacology</searchLink> [Br J Pharmacol] 2026 Aug; Vol. 183 (16), pp. 4698-4714. <i>Date of Electronic Publication: </i>2026 May 04.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley%22">Wiley </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>7502536 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5381 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200071188%22">00071188 </searchLink><i>NLM ISO Abbreviation: </i>Br J Pharmacol <i>Subsets: </i>MEDLINE
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        Value: 10.1111/bph.70486
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      – TitleFull: Annexin A1 alleviates heatstroke by inhibiting RIPK3/MLKL-mediated necroptosis through an FPR2-dependent pathway in male mice.
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              Text: 2026 Aug
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