VEGFR-2 blocker induces pulmonary vascular disease in rats with CRISPR-edited human non-deficient G6PD polymorphism: role of 3D genomic modifications and DNA methylation.

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Title: VEGFR-2 blocker induces pulmonary vascular disease in rats with CRISPR-edited human non-deficient G6PD polymorphism: role of 3D genomic modifications and DNA methylation.
Authors: Signoretti C; Department of Pharmacology, New York Medical College, Valhalla, New York, USA., Matsumura S; Department of Pharmacology, New York Medical College, Valhalla, New York, USA., Doja J; Department of Medicine, Vascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia, USA., Fatehi S; Department of Pharmacology, New York Medical College, Valhalla, New York, USA., Williams C; Department of Pharmacology, New York Medical College, Valhalla, New York, USA., D'silva M; Department of Pharmacology, New York Medical College, Valhalla, New York, USA., Cendali F; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Dzieciatkowska M; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., D'Alessandro A; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Lanier GM; Department of Cardiology, Heart and Vascular Institute, Westchester Medical Center, Valhalla, New York, USA., Gupte SA; Department of Pharmacology, New York Medical College, Valhalla, New York, USA.
Source: British journal of pharmacology [Br J Pharmacol] 2026 Aug; Vol. 183 (16), pp. 4675-4697. Date of Electronic Publication: 2026 May 05.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5381
DOI:10.1111/bph.70452