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VEGFR-2 blocker induces pulmonary vascular disease in rats with CRISPR-edited human non-deficient G6PD polymorphism: role of 3D genomic modifications and DNA methylation.

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Title: VEGFR-2 blocker induces pulmonary vascular disease in rats with CRISPR-edited human non-deficient G6PD polymorphism: role of 3D genomic modifications and DNA methylation.
Authors: Signoretti C; Department of Pharmacology, New York Medical College, Valhalla, New York, USA., Matsumura S; Department of Pharmacology, New York Medical College, Valhalla, New York, USA., Doja J; Department of Medicine, Vascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia, USA., Fatehi S; Department of Pharmacology, New York Medical College, Valhalla, New York, USA., Williams C; Department of Pharmacology, New York Medical College, Valhalla, New York, USA., D'silva M; Department of Pharmacology, New York Medical College, Valhalla, New York, USA., Cendali F; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Dzieciatkowska M; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., D'Alessandro A; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Lanier GM; Department of Cardiology, Heart and Vascular Institute, Westchester Medical Center, Valhalla, New York, USA., Gupte SA; Department of Pharmacology, New York Medical College, Valhalla, New York, USA.
Source: British journal of pharmacology [Br J Pharmacol] 2026 Aug; Vol. 183 (16), pp. 4675-4697. Date of Electronic Publication: 2026 May 05.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: VEGFR-2 blocker induces pulmonary vascular disease in rats with CRISPR-edited human non-deficient G6PD polymorphism: role of 3D genomic modifications and DNA methylation.
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  Data: <searchLink fieldCode="AU" term="%22Signoretti+C%22">Signoretti C</searchLink>; Department of Pharmacology, New York Medical College, Valhalla, New York, USA.<br /><searchLink fieldCode="AU" term="%22Matsumura+S%22">Matsumura S</searchLink>; Department of Pharmacology, New York Medical College, Valhalla, New York, USA.<br /><searchLink fieldCode="AU" term="%22Doja+J%22">Doja J</searchLink>; Department of Medicine, Vascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Fatehi+S%22">Fatehi S</searchLink>; Department of Pharmacology, New York Medical College, Valhalla, New York, USA.<br /><searchLink fieldCode="AU" term="%22Williams+C%22">Williams C</searchLink>; Department of Pharmacology, New York Medical College, Valhalla, New York, USA.<br /><searchLink fieldCode="AU" term="%22D'silva+M%22">D'silva M</searchLink>; Department of Pharmacology, New York Medical College, Valhalla, New York, USA.<br /><searchLink fieldCode="AU" term="%22Cendali+F%22">Cendali F</searchLink>; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Dzieciatkowska+M%22">Dzieciatkowska M</searchLink>; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22D'Alessandro+A%22">D'Alessandro A</searchLink>; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.<br /><searchLink fieldCode="AU" term="%22Lanier+GM%22">Lanier GM</searchLink>; Department of Cardiology, Heart and Vascular Institute, Westchester Medical Center, Valhalla, New York, USA.<br /><searchLink fieldCode="AU" term="%22Gupte+SA%22">Gupte SA</searchLink>; Department of Pharmacology, New York Medical College, Valhalla, New York, USA.
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  Data: <searchLink fieldCode="JN" term="%227502536%22">British journal of pharmacology</searchLink> [Br J Pharmacol] 2026 Aug; Vol. 183 (16), pp. 4675-4697. <i>Date of Electronic Publication: </i>2026 May 05.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley%22">Wiley </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>7502536 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5381 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200071188%22">00071188 </searchLink><i>NLM ISO Abbreviation: </i>Br J Pharmacol <i>Subsets: </i>MEDLINE
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              Text: 2026 Aug
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