Cancer-Associated Fibroblasts Promote Epithelial-Mesenchymal Transition and Classical to Basal Subtype Shift in Pancreatic Cancer.

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Title: Cancer-Associated Fibroblasts Promote Epithelial-Mesenchymal Transition and Classical to Basal Subtype Shift in Pancreatic Cancer.
Authors: Belanger K; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland., Guinn S; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland., Perez B; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland., Cho Y; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland., Tandurella JA; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland., Ramani M; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland., Lee JW; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland., Zabransky DJ; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland., Kartalia E; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland., Patel J; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Zlomke H; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Nicolson NG; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Gross NE; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland., Shin SM; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland., Barrett BC; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland., Sun S; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland., Sun N; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland., Firth E; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland., Hernandez AG; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland., Coyne EM; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland., Cannon CD; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland., Moon E; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland., Charmsaz S; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland., Danilova L; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland., Leatherman JM; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland., Lyman MR; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland., Mitchell JT; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland., Zheng L; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Goggins MG; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland., Lafaro KJ; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., He J; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Shubert CR; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Burns WR; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Fertig EJ; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland.; Department of Applied Mathematics and Statistics, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland.; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland.; Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland.; Departments of Medicine and Epidemiology, University of Maryland School of Medicine, Baltimore, Maryland., Kagohara LT; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland., Jaffee EM; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland., Burkhart RA; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Ho WJ; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland., Zimmerman JW; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg∼Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Source: Cancer research [Cancer Res] 2026 Jul 15; Vol. 86 (14), pp. 3604-3622.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1538-7445
DOI:10.1158/0008-5472.CAN-25-0331