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Blood transcriptomic signatures predict poor outcomes in drug-susceptible pulmonary TB in Brazil.

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Title: Blood transcriptomic signatures predict poor outcomes in drug-susceptible pulmonary TB in Brazil.
Authors: Mendelsohn SC; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7935, Cape Town, South Africa., Andrade BB; Laboratório de Pesquisa Clínica e Translacional, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, 40296-710, Bahia, Brazil., Araújo-Pereira M; Laboratório de Pesquisa Clínica e Translacional, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, 40296-710, Bahia, Brazil., Amorim GC; Vanderbilt University Medical Center, Nashville, 37232, TN, United States., Erasmus M; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7935, Cape Town, South Africa., Andrade AMS; Laboratório de Pesquisa Clínica e Translacional, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, 40296-710, Bahia, Brazil., Fisher M; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7935, Cape Town, South Africa., Figueiredo MC; Vanderbilt University Medical Center, Nashville, 37232, TN, United States., Muwanga VM; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7935, Cape Town, South Africa., Kritski AL; Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rua Prof Rodolpho Paulo Rocco, 255, Centro de Pesquisa em Tuberculose, Cidade Universitária, 21941-913, Rio de Janeiro, RJ, Brazil., Cordeiro-Santos M; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, 69040-000, Amazonas, Brazil., Rolla VC; Laboratorio de Pesquisa Clinica em Micobacterioses, Instituto Nacional de Infectologia Evandro Chagas, Fiocruz, 21040-360, Rio de Janeiro, Brazil., Hatherill M; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7935, Cape Town, South Africa., Sterling TR; Vanderbilt University Medical Center, Nashville, 37232, TN, United States., Scriba TJ; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7935, Cape Town, South Africa.
Corporate Authors: members of the RePORT South Africa, RePORT-Brazil Consortia
Source: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2026 Mar 30. Date of Electronic Publication: 2026 Mar 30.
Publication Type: Journal Article
Journal Info: Publisher: American Thoracic Society Country of Publication: England NLM ID: 9421642 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-4970 (Electronic) Linking ISSN: 1073449X NLM ISO Abbreviation: Am J Respir Crit Care Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Mendelsohn+SC%22">Mendelsohn SC</searchLink>; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7935, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Andrade+BB%22">Andrade BB</searchLink>; Laboratório de Pesquisa Clínica e Translacional, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, 40296-710, Bahia, Brazil.<br /><searchLink fieldCode="AU" term="%22Araújo-Pereira+M%22">Araújo-Pereira M</searchLink>; Laboratório de Pesquisa Clínica e Translacional, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, 40296-710, Bahia, Brazil.<br /><searchLink fieldCode="AU" term="%22Amorim+GC%22">Amorim GC</searchLink>; Vanderbilt University Medical Center, Nashville, 37232, TN, United States.<br /><searchLink fieldCode="AU" term="%22Erasmus+M%22">Erasmus M</searchLink>; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7935, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Andrade+AMS%22">Andrade AMS</searchLink>; Laboratório de Pesquisa Clínica e Translacional, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, 40296-710, Bahia, Brazil.<br /><searchLink fieldCode="AU" term="%22Fisher+M%22">Fisher M</searchLink>; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7935, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Figueiredo+MC%22">Figueiredo MC</searchLink>; Vanderbilt University Medical Center, Nashville, 37232, TN, United States.<br /><searchLink fieldCode="AU" term="%22Muwanga+VM%22">Muwanga VM</searchLink>; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7935, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Kritski+AL%22">Kritski AL</searchLink>; Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rua Prof Rodolpho Paulo Rocco, 255, Centro de Pesquisa em Tuberculose, Cidade Universitária, 21941-913, Rio de Janeiro, RJ, Brazil.<br /><searchLink fieldCode="AU" term="%22Cordeiro-Santos+M%22">Cordeiro-Santos M</searchLink>; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, 69040-000, Amazonas, Brazil.<br /><searchLink fieldCode="AU" term="%22Rolla+VC%22">Rolla VC</searchLink>; Laboratorio de Pesquisa Clinica em Micobacterioses, Instituto Nacional de Infectologia Evandro Chagas, Fiocruz, 21040-360, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Hatherill+M%22">Hatherill M</searchLink>; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7935, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Sterling+TR%22">Sterling TR</searchLink>; Vanderbilt University Medical Center, Nashville, 37232, TN, United States.<br /><searchLink fieldCode="AU" term="%22Scriba+TJ%22">Scriba TJ</searchLink>; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7935, Cape Town, South Africa.
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