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Mosaic loss of Y chromosome associates with lung function, emphysema, and epigenetic aging.

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Title: Mosaic loss of Y chromosome associates with lung function, emphysema, and epigenetic aging.
Authors: Saw WY; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, United States.; Department of Medicine, Harvard Medical School, Boston, MA, United States., Kim K; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, United States.; Department of Medicine, Harvard Medical School, Boston, MA, United States., Huang Y; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, United States., Yun JH; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, United States.; Department of Medicine, Harvard Medical School, Boston, MA, United States., Ma X; Division of Biostatistics, Data Science Institute, Medical College of Wisconsin, Milwaukee, WI, United States., Bacon J; Department of Computer Science, Department of Biological Sciences, University of Wisconsin Milwaukee, Milwaukee, WI, United States., Pershad Y; Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, United States., Levy D; Framingham Heart Study, Framingham, MA, United States.; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States., O'Connor GT; Department of Medicine, The Pulmonary Center , Boston University Chobanian and Avedisian School of Medicine, Boston, MA, United States.; Section of Pulmonary, Allergy, Sleep & Critical Care Medicine, Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, United States., Boerwinkle E; Human Genetics Center, Department of Epidemiology, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, United States., Barr RG; Department of Medicine, Columbia University Medical Center, New York, NY, United States.; Department of Epidemiology, Columbia University Medical Center, New York, NY, United States., Rich SS; Department of Genome Sciences, University of Virginia School of Medicine, Charlottesville, VA, United States., Rotter JI; Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, United States., Carson AP; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, United States., Raffield LM; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Gharib SA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, United States.; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, WA, United States., Bartz TM; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, WA, United States.; Department of Biostatistics, University of Washington, Seattle, WA, United States., Psaty BM; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, WA, United States.; Department of Epidemiology, University of Washington, Seattle, WA, United States., Sofer T; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, United States., North KE; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Kaplan RC; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, United States.; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States., Oelsner EC; Division of General Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, United States., Manichaikul A; Department of Genome Sciences, University of Virginia School of Medicine, Charlottesville, VA, United States., Bick AG; Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, United States., Scheet P; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, United States., Reiner AP; Department of Epidemiology, University of Washington, Seattle, WA, United States., Jakubek YA; Department of Internal Medicine, University of Kentucky, Lexington, KY, United States., Auer PL; Division of Biostatistics, Data Science Institute, Medical College of Wisconsin, Milwaukee, WI, United States.; Cancer Center, Medical College of Wisconsin, Milwaukee, WI, United States., Cho MH; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, United States.; Department of Medicine, Harvard Medical School, Boston, MA, United States., DeMeo DL; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, United States.; Department of Medicine, Harvard Medical School, Boston, MA, United States.
Corporate Authors: NHLBI Trans-Omics for Precision Medicine Consortium
Source: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2026 Jul 01; Vol. 212 (7), pp. 1483-1494.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Thoracic Society Country of Publication: England NLM ID: 9421642 Publication Model: Print Cited Medium: Internet ISSN: 1535-4970 (Electronic) Linking ISSN: 1073449X NLM ISO Abbreviation: Am J Respir Crit Care Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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