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Prostaglandin I2 receptor activation promotes alveolar regeneration via the JUN/p53 pathway.

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Title: Prostaglandin I2 receptor activation promotes alveolar regeneration via the JUN/p53 pathway.
Authors: Yu T; Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, State Key Laboratory of Experimental Hematology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China., Liu J; Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, State Key Laboratory of Experimental Hematology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China., Ma Y; Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, State Key Laboratory of Experimental Hematology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China., Wang L; Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, State Key Laboratory of Experimental Hematology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China., Wang Y; Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, State Key Laboratory of Experimental Hematology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China., Pan T; Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, State Key Laboratory of Experimental Hematology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China., Chen P; Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, Tianjin, China., Liu Q; Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, State Key Laboratory of Experimental Hematology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China., Wang JW; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Chen H; Department of Respiratory Medicine, Haihe Hospital, Tianjin University, Tianjin, China., Wu X; State Key Laboratory of Experimental Hematology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Key Laboratory of Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Cell Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China., Chen J; Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, Tianjin, China., Hu X; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China., Tao B; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China., Shen Y; Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, State Key Laboratory of Experimental Hematology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Source: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2026 Jul 01; Vol. 212 (7), pp. 1467-1482.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Thoracic Society Country of Publication: England NLM ID: 9421642 Publication Model: Print Cited Medium: Internet ISSN: 1535-4970 (Electronic) Linking ISSN: 1073449X NLM ISO Abbreviation: Am J Respir Crit Care Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Prostaglandin I2 receptor activation promotes alveolar regeneration via the JUN/p53 pathway.
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  Data: <searchLink fieldCode="AU" term="%22Yu+T%22">Yu T</searchLink>; Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, State Key Laboratory of Experimental Hematology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, State Key Laboratory of Experimental Hematology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Ma+Y%22">Ma Y</searchLink>; Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, State Key Laboratory of Experimental Hematology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, State Key Laboratory of Experimental Hematology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, State Key Laboratory of Experimental Hematology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Pan+T%22">Pan T</searchLink>; Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, State Key Laboratory of Experimental Hematology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Chen+P%22">Chen P</searchLink>; Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Liu+Q%22">Liu Q</searchLink>; Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, State Key Laboratory of Experimental Hematology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Wang+JW%22">Wang JW</searchLink>; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; Department of Respiratory Medicine, Haihe Hospital, Tianjin University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Wu+X%22">Wu X</searchLink>; State Key Laboratory of Experimental Hematology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Key Laboratory of Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Cell Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Hu+X%22">Hu X</searchLink>; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Tao+B%22">Tao B</searchLink>; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Shen+Y%22">Shen Y</searchLink>; Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Center for Cardiovascular Diseases, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, State Key Laboratory of Experimental Hematology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
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  Data: <searchLink fieldCode="JN" term="%229421642%22">American journal of respiratory and critical care medicine</searchLink> [Am J Respir Crit Care Med] 2026 Jul 01; Vol. 212 (7), pp. 1467-1482.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Thoracic+Society%22">American Thoracic Society </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9421642 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1535-4970 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221073449X%22">1073449X </searchLink><i>NLM ISO Abbreviation: </i>Am J Respir Crit Care Med <i>Subsets: </i>MEDLINE
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        Value: 10.1093/ajrccm/aamag116
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        Text: English
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      – TitleFull: Prostaglandin I2 receptor activation promotes alveolar regeneration via the JUN/p53 pathway.
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              Text: 2026 Jul 01
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