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Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics.

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Title: Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics.
Authors: Papadopoli D; Lady Davis Institute, SMBD JGH, McGill University, Montréal, Canada.; Gerald Bronfman Department of Oncology, McGill University, Montréal, Canada., Palia R; Lady Davis Institute, SMBD JGH, McGill University, Montréal, Canada.; Department of Experimental Medicine, McGill University, Montréal, Canada., Jovanovic P; Lady Davis Institute, SMBD JGH, McGill University, Montréal, Canada.; Department of Experimental Medicine, McGill University, Montréal, Canada., Tabariès S; Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, Canada., Ciccolini E; Lady Davis Institute, SMBD JGH, McGill University, Montréal, Canada.; Department of Experimental Medicine, McGill University, Montréal, Canada., Sabourin V; Lady Davis Institute, SMBD JGH, McGill University, Montréal, Canada., Igelmann S; VIB Center for Cancer Biology, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium., McLaughlan S; Department of Biochemistry, McGill University, Montréal, Canada., Zhan L; Department of Biochemistry, McGill University, Montréal, Canada., Kim H; Department of Experimental Medicine, McGill University, Montréal, Canada., Chekkal N; Department of Biochemistry, McGill University, Montréal, Canada., Szkop KJ; Department of Oncology-Pathology, Science for Life Laboratory, Karolinska Institute, Stockholm, Sweden., Bertomeu T; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Canada., Zeng J; Lady Davis Institute, SMBD JGH, McGill University, Montréal, Canada., Vassalakis J; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Canada., Afzali F; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Canada., Mzoughi S; Center of OncoGenomics and Innovative Therapeutics (COGIT), Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, United States., Guccione E; Center of OncoGenomics and Innovative Therapeutics (COGIT), Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, United States., Tyers M; Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Canada., Avizonis D; Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, Canada.; Metabolomics Innovation Resource, McGill University, Montréal, Canada., Larsson O; Department of Oncology-Pathology, Science for Life Laboratory, Karolinska Institute, Stockholm, Sweden., Postovit LM; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Canada., Djuranovic S; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, United States.; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, United States., Ursini-Siegel J; Lady Davis Institute, SMBD JGH, McGill University, Montréal, Canada.; Gerald Bronfman Department of Oncology, McGill University, Montréal, Canada.; Department of Experimental Medicine, McGill University, Montréal, Canada.; Department of Biochemistry, McGill University, Montréal, Canada., Siegel PM; Department of Experimental Medicine, McGill University, Montréal, Canada.; Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, Canada.; Department of Biochemistry, McGill University, Montréal, Canada., Pollak M; Lady Davis Institute, SMBD JGH, McGill University, Montréal, Canada.; Gerald Bronfman Department of Oncology, McGill University, Montréal, Canada.; Department of Experimental Medicine, McGill University, Montréal, Canada., Topisirovic I; Gerald Bronfman Department of Oncology, McGill University, Montréal, Canada.; Department of Experimental Medicine, McGill University, Montréal, Canada.; Department of Biochemistry, McGill University, Montréal, Canada.
Source: ELife [Elife] 2026 May 05; Vol. 14. Date of Electronic Publication: 2026 May 05.
Publication Type: Journal Article
Journal Info: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
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  Data: Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics.
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  Data: <searchLink fieldCode="AU" term="%22Papadopoli+D%22">Papadopoli D</searchLink>; Lady Davis Institute, SMBD JGH, McGill University, Montréal, Canada.; Gerald Bronfman Department of Oncology, McGill University, Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Palia+R%22">Palia R</searchLink>; Lady Davis Institute, SMBD JGH, McGill University, Montréal, Canada.; Department of Experimental Medicine, McGill University, Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Jovanovic+P%22">Jovanovic P</searchLink>; Lady Davis Institute, SMBD JGH, McGill University, Montréal, Canada.; Department of Experimental Medicine, McGill University, Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Tabariès+S%22">Tabariès S</searchLink>; Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Ciccolini+E%22">Ciccolini E</searchLink>; Lady Davis Institute, SMBD JGH, McGill University, Montréal, Canada.; Department of Experimental Medicine, McGill University, Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Sabourin+V%22">Sabourin V</searchLink>; Lady Davis Institute, SMBD JGH, McGill University, Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Igelmann+S%22">Igelmann S</searchLink>; VIB Center for Cancer Biology, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22McLaughlan+S%22">McLaughlan S</searchLink>; Department of Biochemistry, McGill University, Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Zhan+L%22">Zhan L</searchLink>; Department of Biochemistry, McGill University, Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Kim+H%22">Kim H</searchLink>; Department of Experimental Medicine, McGill University, Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Chekkal+N%22">Chekkal N</searchLink>; Department of Biochemistry, McGill University, Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Szkop+KJ%22">Szkop KJ</searchLink>; Department of Oncology-Pathology, Science for Life Laboratory, Karolinska Institute, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Bertomeu+T%22">Bertomeu T</searchLink>; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Zeng+J%22">Zeng J</searchLink>; Lady Davis Institute, SMBD JGH, McGill University, Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Vassalakis+J%22">Vassalakis J</searchLink>; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Canada.<br /><searchLink fieldCode="AU" term="%22Afzali+F%22">Afzali F</searchLink>; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Canada.<br /><searchLink fieldCode="AU" term="%22Mzoughi+S%22">Mzoughi S</searchLink>; Center of OncoGenomics and Innovative Therapeutics (COGIT), Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, United States.<br /><searchLink fieldCode="AU" term="%22Guccione+E%22">Guccione E</searchLink>; Center of OncoGenomics and Innovative Therapeutics (COGIT), Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, United States.<br /><searchLink fieldCode="AU" term="%22Tyers+M%22">Tyers M</searchLink>; Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Avizonis+D%22">Avizonis D</searchLink>; Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, Canada.; Metabolomics Innovation Resource, McGill University, Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Larsson+O%22">Larsson O</searchLink>; Department of Oncology-Pathology, Science for Life Laboratory, Karolinska Institute, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Postovit+LM%22">Postovit LM</searchLink>; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Canada.<br /><searchLink fieldCode="AU" term="%22Djuranovic+S%22">Djuranovic S</searchLink>; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, United States.; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, United States.<br /><searchLink fieldCode="AU" term="%22Ursini-Siegel+J%22">Ursini-Siegel J</searchLink>; Lady Davis Institute, SMBD JGH, McGill University, Montréal, Canada.; Gerald Bronfman Department of Oncology, McGill University, Montréal, Canada.; Department of Experimental Medicine, McGill University, Montréal, Canada.; Department of Biochemistry, McGill University, Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Siegel+PM%22">Siegel PM</searchLink>; Department of Experimental Medicine, McGill University, Montréal, Canada.; Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, Canada.; Department of Biochemistry, McGill University, Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Pollak+M%22">Pollak M</searchLink>; Lady Davis Institute, SMBD JGH, McGill University, Montréal, Canada.; Gerald Bronfman Department of Oncology, McGill University, Montréal, Canada.; Department of Experimental Medicine, McGill University, Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Topisirovic+I%22">Topisirovic I</searchLink>; Gerald Bronfman Department of Oncology, McGill University, Montréal, Canada.; Department of Experimental Medicine, McGill University, Montréal, Canada.; Department of Biochemistry, McGill University, Montréal, Canada.
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