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Neoadjuvant Single-Cycle Pembrolizumab for Stage I-III MMR-Deficient Colon Cancer: The RESET-C Trial.

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Title: Neoadjuvant Single-Cycle Pembrolizumab for Stage I-III MMR-Deficient Colon Cancer: The RESET-C Trial.
Authors: Gögenur I; Center for Surgical Science, Zealand University Hospital, Køge, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Justesen TF; Center for Surgical Science, Zealand University Hospital, Køge, Denmark., Tarpgaard LS; Department of Oncology, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, University of Southern Denmark, Odense, Denmark., Bulut M; Center for Surgical Science, Zealand University Hospital, Køge, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Surgery, Zealand University Hospital, Køge, Denmark., Hansen TF; Department of Oncology, Vejle Hospital, Vejle, Denmark., Jensen LH; Department of Oncology, Vejle Hospital, Vejle, Denmark., Rahr HB; Department of Surgery, Colorectal Cancer Center South at Vejle Hospital, University Hospital of Southern Denmark, Vejle, Denmark., Gögenur M; Center for Surgical Science, Zealand University Hospital, Køge, Denmark., Kirkegaard T; Center for Surgical Science, Zealand University Hospital, Køge, Denmark., Balsevicius L; Center for Surgical Science, Zealand University Hospital, Køge, Denmark., Chieng M; Center for Surgical Science, Zealand University Hospital, Køge, Denmark., Raskov H; Center for Surgical Science, Zealand University Hospital, Køge, Denmark., Sørensen MKS; Center for Surgical Science, Zealand University Hospital, Køge, Denmark., Petersen PC; Department of Oncology, Zealand University Hospital, Roskilde, Denmark., Eriksen JR; Department of Surgery, Zealand University Hospital, Køge, Denmark., Salomon S; Department of Surgery, Odense University Hospital, Odense, Denmark., Fiehn AK; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Pathology, Zealand University Hospital, Roskilde, Denmark., Mikkelsen MD; Department of Pathology, Zealand University Hospital, Roskilde, Denmark., Brandsborg S; Department of Surgery, Horsens Regional Hospital, Horsens, Denmark., Gotschalck KA; Department of Surgery, Horsens Regional Hospital, Horsens, Denmark., Emmertsen KJ; Department of Surgery, Randers Regional Hospital, Randers, Denmark., Ramlov A; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark., Born PW; Department of Surgery, Hvidovre Hospital, Hvidovre, Denmark., Thorlacius-Ussing O; Department of Gastrointestinal Surgery, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, Aalborg University, Denmark., Lauritzen MB; Department of Gastrointestinal Surgery, Aalborg University Hospital, Aalborg, Denmark., Olesen RK; Department of Oncology, Aalborg University Hospital, Aalborg, Denmark., Poulsen LØ; Department of Oncology, Aalborg University Hospital, Aalborg, Denmark., Lykke J; Department of Surgery, Herlev and Gentofte University Hospital, Herlev, Denmark., Schou J; Department of Oncology, Herlev and Gentofte University Hospital, Herlev, Denmark., Buskov L; Department of Radiology, Bispebjerg Hospital, Bispebjerg, Denmark., Krarup PM; Department of Surgical Gastroenterology, Bispebjerg Hospital, Bispebjerg, Denmark., Andersen CL; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Pallisgaard N; Department of Pathology, Zealand University Hospital, Roskilde, Denmark.; Department of Science and Environment, Roskilde University, Denmark., Pfeiffer P; Department of Oncology, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, University of Southern Denmark, Odense, Denmark., Qvortrup C; Department of Oncology, Rigshospitalet, Copenhagen, Denmark.
Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2026 Jun 20; Vol. 44 (18), pp. 1687-1696. Date of Electronic Publication: 2026 May 05.
Publication Type: Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 8309333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-7755 (Electronic) Linking ISSN: 0732183X NLM ISO Abbreviation: J Clin Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Neoadjuvant Single-Cycle Pembrolizumab for Stage I-III MMR-Deficient Colon Cancer: The RESET-C Trial.
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  Data: <searchLink fieldCode="AU" term="%22Gögenur+I%22">Gögenur I</searchLink>; Center for Surgical Science, Zealand University Hospital, Køge, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Justesen+TF%22">Justesen TF</searchLink>; Center for Surgical Science, Zealand University Hospital, Køge, Denmark.<br /><searchLink fieldCode="AU" term="%22Tarpgaard+LS%22">Tarpgaard LS</searchLink>; Department of Oncology, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Bulut+M%22">Bulut M</searchLink>; Center for Surgical Science, Zealand University Hospital, Køge, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Surgery, Zealand University Hospital, Køge, Denmark.<br /><searchLink fieldCode="AU" term="%22Hansen+TF%22">Hansen TF</searchLink>; Department of Oncology, Vejle Hospital, Vejle, Denmark.<br /><searchLink fieldCode="AU" term="%22Jensen+LH%22">Jensen LH</searchLink>; Department of Oncology, Vejle Hospital, Vejle, Denmark.<br /><searchLink fieldCode="AU" term="%22Rahr+HB%22">Rahr HB</searchLink>; Department of Surgery, Colorectal Cancer Center South at Vejle Hospital, University Hospital of Southern Denmark, Vejle, Denmark.<br /><searchLink fieldCode="AU" term="%22Gögenur+M%22">Gögenur M</searchLink>; Center for Surgical Science, Zealand University Hospital, Køge, Denmark.<br /><searchLink fieldCode="AU" term="%22Kirkegaard+T%22">Kirkegaard T</searchLink>; Center for Surgical Science, Zealand University Hospital, Køge, Denmark.<br /><searchLink fieldCode="AU" term="%22Balsevicius+L%22">Balsevicius L</searchLink>; Center for Surgical Science, Zealand University Hospital, Køge, Denmark.<br /><searchLink fieldCode="AU" term="%22Chieng+M%22">Chieng M</searchLink>; Center for Surgical Science, Zealand University Hospital, Køge, Denmark.<br /><searchLink fieldCode="AU" term="%22Raskov+H%22">Raskov H</searchLink>; Center for Surgical Science, Zealand University Hospital, Køge, Denmark.<br /><searchLink fieldCode="AU" term="%22Sørensen+MKS%22">Sørensen MKS</searchLink>; Center for Surgical Science, Zealand University Hospital, Køge, Denmark.<br /><searchLink fieldCode="AU" term="%22Petersen+PC%22">Petersen PC</searchLink>; Department of Oncology, Zealand University Hospital, Roskilde, Denmark.<br /><searchLink fieldCode="AU" term="%22Eriksen+JR%22">Eriksen JR</searchLink>; Department of Surgery, Zealand University Hospital, Køge, Denmark.<br /><searchLink fieldCode="AU" term="%22Salomon+S%22">Salomon S</searchLink>; Department of Surgery, Odense University Hospital, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Fiehn+AK%22">Fiehn AK</searchLink>; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Pathology, Zealand University Hospital, Roskilde, Denmark.<br /><searchLink fieldCode="AU" term="%22Mikkelsen+MD%22">Mikkelsen MD</searchLink>; Department of Pathology, Zealand University Hospital, Roskilde, Denmark.<br /><searchLink fieldCode="AU" term="%22Brandsborg+S%22">Brandsborg S</searchLink>; Department of Surgery, Horsens Regional Hospital, Horsens, Denmark.<br /><searchLink fieldCode="AU" term="%22Gotschalck+KA%22">Gotschalck KA</searchLink>; Department of Surgery, Horsens Regional Hospital, Horsens, Denmark.<br /><searchLink fieldCode="AU" term="%22Emmertsen+KJ%22">Emmertsen KJ</searchLink>; Department of Surgery, Randers Regional Hospital, Randers, Denmark.<br /><searchLink fieldCode="AU" term="%22Ramlov+A%22">Ramlov A</searchLink>; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Born+PW%22">Born PW</searchLink>; Department of Surgery, Hvidovre Hospital, Hvidovre, Denmark.<br /><searchLink fieldCode="AU" term="%22Thorlacius-Ussing+O%22">Thorlacius-Ussing O</searchLink>; Department of Gastrointestinal Surgery, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, Aalborg University, Denmark.<br /><searchLink fieldCode="AU" term="%22Lauritzen+MB%22">Lauritzen MB</searchLink>; Department of Gastrointestinal Surgery, Aalborg University Hospital, Aalborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Olesen+RK%22">Olesen RK</searchLink>; Department of Oncology, Aalborg University Hospital, Aalborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Poulsen+LØ%22">Poulsen LØ</searchLink>; Department of Oncology, Aalborg University Hospital, Aalborg, Denmark.<br /><searchLink fieldCode="AU" term="%22Lykke+J%22">Lykke J</searchLink>; Department of Surgery, Herlev and Gentofte University Hospital, Herlev, Denmark.<br /><searchLink fieldCode="AU" term="%22Schou+J%22">Schou J</searchLink>; Department of Oncology, Herlev and Gentofte University Hospital, Herlev, Denmark.<br /><searchLink fieldCode="AU" term="%22Buskov+L%22">Buskov L</searchLink>; Department of Radiology, Bispebjerg Hospital, Bispebjerg, Denmark.<br /><searchLink fieldCode="AU" term="%22Krarup+PM%22">Krarup PM</searchLink>; Department of Surgical Gastroenterology, Bispebjerg Hospital, Bispebjerg, Denmark.<br /><searchLink fieldCode="AU" term="%22Andersen+CL%22">Andersen CL</searchLink>; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Pallisgaard+N%22">Pallisgaard N</searchLink>; Department of Pathology, Zealand University Hospital, Roskilde, Denmark.; Department of Science and Environment, Roskilde University, Denmark.<br /><searchLink fieldCode="AU" term="%22Pfeiffer+P%22">Pfeiffer P</searchLink>; Department of Oncology, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Qvortrup+C%22">Qvortrup C</searchLink>; Department of Oncology, Rigshospitalet, Copenhagen, Denmark.
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  Data: <searchLink fieldCode="JN" term="%228309333%22">Journal of clinical oncology : official journal of the American Society of Clinical Oncology</searchLink> [J Clin Oncol] 2026 Jun 20; Vol. 44 (18), pp. 1687-1696. <i>Date of Electronic Publication: </i>2026 May 05.
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