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Combined Inhibition of ATR and Ribonucleotide Reductase Induces Synergistic Antineoplastic Activity in Osteosarcoma Cells.

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Title: Combined Inhibition of ATR and Ribonucleotide Reductase Induces Synergistic Antineoplastic Activity in Osteosarcoma Cells.
Authors: Aderhold N; Department of Paediatric and Adolescent Medicine, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany.; Research Centre Lobeda, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany.; Comprehensive Cancer Centre Central Germany (CCCG), Jena, Germany., Immesberger L; Department of Paediatric and Adolescent Medicine, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany.; Research Centre Lobeda, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany.; Comprehensive Cancer Centre Central Germany (CCCG), Jena, Germany., Becker S; Department of Paediatric and Adolescent Medicine, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany.; Research Centre Lobeda, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany.; Comprehensive Cancer Centre Central Germany (CCCG), Jena, Germany., Milde T; Department of Paediatric and Adolescent Medicine, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany.; Comprehensive Cancer Centre Central Germany (CCCG), Jena, Germany.; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany., Gruhn B; Department of Paediatric and Adolescent Medicine, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany.; Comprehensive Cancer Centre Central Germany (CCCG), Jena, Germany., Sonnemann J; Department of Paediatric and Adolescent Medicine, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany.; Research Centre Lobeda, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany.; Comprehensive Cancer Centre Central Germany (CCCG), Jena, Germany.
Source: Cancer reports (Hoboken, N.J.) [Cancer Rep (Hoboken)] 2026 May; Vol. 9 (5), pp. e70568.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 101747728 Publication Model: Print Cited Medium: Internet ISSN: 2573-8348 (Electronic) Linking ISSN: 25738348 NLM ISO Abbreviation: Cancer Rep (Hoboken) Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Combined Inhibition of ATR and Ribonucleotide Reductase Induces Synergistic Antineoplastic Activity in Osteosarcoma Cells.
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  Data: <searchLink fieldCode="AU" term="%22Aderhold+N%22">Aderhold N</searchLink>; Department of Paediatric and Adolescent Medicine, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany.; Research Centre Lobeda, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany.; Comprehensive Cancer Centre Central Germany (CCCG), Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Immesberger+L%22">Immesberger L</searchLink>; Department of Paediatric and Adolescent Medicine, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany.; Research Centre Lobeda, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany.; Comprehensive Cancer Centre Central Germany (CCCG), Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Becker+S%22">Becker S</searchLink>; Department of Paediatric and Adolescent Medicine, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany.; Research Centre Lobeda, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany.; Comprehensive Cancer Centre Central Germany (CCCG), Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Milde+T%22">Milde T</searchLink>; Department of Paediatric and Adolescent Medicine, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany.; Comprehensive Cancer Centre Central Germany (CCCG), Jena, Germany.; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Gruhn+B%22">Gruhn B</searchLink>; Department of Paediatric and Adolescent Medicine, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany.; Comprehensive Cancer Centre Central Germany (CCCG), Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Sonnemann+J%22">Sonnemann J</searchLink>; Department of Paediatric and Adolescent Medicine, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany.; Research Centre Lobeda, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany.; Comprehensive Cancer Centre Central Germany (CCCG), Jena, Germany.
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  Data: <searchLink fieldCode="JN" term="%22101747728%22">Cancer reports (Hoboken, N.J.)</searchLink> [Cancer Rep (Hoboken)] 2026 May; Vol. 9 (5), pp. e70568.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22John+Wiley+%26+Sons%2C+Inc%22">John Wiley & Sons, Inc </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101747728 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>2573-8348 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2225738348%22">25738348 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Rep (Hoboken) <i>Subsets: </i>MEDLINE
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        Text: English
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              Text: 2026 May
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