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Human brain changes after first psilocybin use.

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Title: Human brain changes after first psilocybin use.
Authors: Lyons T; Division of Psychiatry, Department of Brain Sciences, Centre for Psychedelic Research, Imperial College London, London, UK., Spriggs M; Division of Psychiatry, Department of Brain Sciences, Centre for Psychedelic Research, Imperial College London, London, UK., Kerkelä L; UCL Great Ormond Street Institute of Child Health, University College London, London, UK., Rosas FE; Division of Psychiatry, Department of Brain Sciences, Centre for Psychedelic Research, Imperial College London, London, UK.; Department of Informatics, University of Sussex, Brighton, UK.; Data Science Institute, Imperial College London, London, UK.; Centre for Complexity Science, Imperial College London, London, UK.; Centre for Eudaimonia and Human Flourishing, University of Oxford, Oxford, UK., Roseman L; Division of Psychiatry, Department of Brain Sciences, Centre for Psychedelic Research, Imperial College London, London, UK., Mediano PAM; Centre for Complexity Science, Imperial College London, London, UK.; Department of Psychology, University of Cambridge, Cambridge, UK.; Department of Psychology, Queen Mary University of London, London, UK., Timmermann C; Division of Psychiatry, Department of Brain Sciences, Centre for Psychedelic Research, Imperial College London, London, UK., Oestreich L; School of Psychology and Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland, Brisbane, QLD, Australia., Pagni BA; NYU Langone Center for Psychedelic Medicine, Department of Psychiatry, NYU Grossman School of Medicine, New York, NY, USA., Zeifman RJ; Division of Psychiatry, Department of Brain Sciences, Centre for Psychedelic Research, Imperial College London, London, UK.; NYU Langone Center for Psychedelic Medicine, Department of Psychiatry, NYU Grossman School of Medicine, New York, NY, USA.; Department of Psychology, The New School for Social Research, New York, NY, USA., Hampshire A; Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK., Trender W; Department of Brain Sciences, Imperial College London, London, UK., Douglass HM; Division of Psychiatry, Department of Brain Sciences, Centre for Psychedelic Research, Imperial College London, London, UK., Girn M; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.; Carhart-Harris Lab, Department of Neurology, University of California San Francisco, San Francisco, CA, USA., Godfrey K; Division of Psychiatry, Department of Brain Sciences, Centre for Psychedelic Research, Imperial College London, London, UK., Kettner H; Division of Psychiatry, Department of Brain Sciences, Centre for Psychedelic Research, Imperial College London, London, UK.; Carhart-Harris Lab, Department of Neurology, University of California San Francisco, San Francisco, CA, USA., Sharif F; Division of Psychiatry, Department of Brain Sciences, Centre for Psychedelic Research, Imperial College London, London, UK., Espasiano L; Division of Psychiatry, Department of Brain Sciences, Centre for Psychedelic Research, Imperial College London, London, UK., Gazzaley A; Neuroscape, Department of Neurology, University of California San Francisco, San Francisco, CA, USA., Wall MB; Invicro London, Hammersmith Hospital, Faculty of Medicine, Imperial College London, London, UK., Erritzoe D; Division of Psychiatry, Department of Brain Sciences, Centre for Psychedelic Research, Imperial College London, London, UK., Nutt DJ; Division of Psychiatry, Department of Brain Sciences, Centre for Psychedelic Research, Imperial College London, London, UK., Carhart-Harris RL; Division of Psychiatry, Department of Brain Sciences, Centre for Psychedelic Research, Imperial College London, London, UK. robin.carhart-harris@ucsf.edu.; Carhart-Harris Lab, Department of Neurology, University of California San Francisco, San Francisco, CA, USA. robin.carhart-harris@ucsf.edu.
Source: Nature communications [Nat Commun] 2026 May 05; Vol. 17 (1). Date of Electronic Publication: 2026 May 05.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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Division of Psychiatry, Department of Brain Sciences, Centre for Psychedelic Research, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Mediano+PAM%22">Mediano PAM</searchLink>; Centre for Complexity Science, Imperial College London, London, UK.; Department of Psychology, University of Cambridge, Cambridge, UK.; Department of Psychology, Queen Mary University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Timmermann+C%22">Timmermann C</searchLink>; Division of Psychiatry, Department of Brain Sciences, Centre for Psychedelic Research, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Oestreich+L%22">Oestreich L</searchLink>; School of Psychology and Australian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Pagni+BA%22">Pagni BA</searchLink>; NYU Langone Center for Psychedelic Medicine, Department of Psychiatry, NYU Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Zeifman+RJ%22">Zeifman RJ</searchLink>; Division of Psychiatry, Department of Brain Sciences, Centre for Psychedelic Research, Imperial College London, London, UK.; NYU Langone Center for Psychedelic Medicine, Department of Psychiatry, NYU Grossman School of Medicine, New York, NY, USA.; Department of Psychology, The New School for Social Research, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hampshire+A%22">Hampshire A</searchLink>; Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Trender+W%22">Trender W</searchLink>; Department of Brain Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Douglass+HM%22">Douglass HM</searchLink>; Division of Psychiatry, Department of Brain Sciences, Centre for Psychedelic Research, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Girn+M%22">Girn M</searchLink>; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.; 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Neuroscape, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wall+MB%22">Wall MB</searchLink>; Invicro London, Hammersmith Hospital, Faculty of Medicine, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Erritzoe+D%22">Erritzoe D</searchLink>; Division of Psychiatry, Department of Brain Sciences, Centre for Psychedelic Research, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Nutt+DJ%22">Nutt DJ</searchLink>; Division of Psychiatry, Department of Brain Sciences, Centre for Psychedelic Research, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Carhart-Harris+RL%22">Carhart-Harris RL</searchLink>; Division of Psychiatry, Department of Brain Sciences, Centre for Psychedelic Research, Imperial College London, London, UK. robin.carhart-harris@ucsf.edu.; Carhart-Harris Lab, Department of Neurology, University of California San Francisco, San Francisco, CA, USA. robin.carhart-harris@ucsf.edu.
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