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Monovalent and multivalent OspA mRNA-LNP vaccines elicit functional antibodies and protect against Borrelia burgdorferi in mice.

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Title: Monovalent and multivalent OspA mRNA-LNP vaccines elicit functional antibodies and protect against Borrelia burgdorferi in mice.
Authors: Finn MB; Infectious Disease Research, Moderna, Inc., Cambridge, MA, USA., Willsey G; Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY, USA., Piazza CL; Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY, USA., Clendenen L; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA., Shrestha M; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA., You SS; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA., Ma L; Infectious Disease Research, Moderna, Inc., Cambridge, MA, USA., Dhingra Y; Infectious Disease Research, Moderna, Inc., Cambridge, MA, USA., Laciak AR; Infectious Disease Research, Moderna, Inc., Cambridge, MA, USA., Uggowitzer KA; Infectious Disease Research, Moderna, Inc., Cambridge, MA, USA., Obiero JM; Infectious Disease Research, Moderna, Inc., Cambridge, MA, USA., Freeman-Gallant G; Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY, USA., Natarajan H; Infectious Disease Research, Moderna, Inc., Cambridge, MA, USA., Green S; Infectious Disease Research, Moderna, Inc., Cambridge, MA, USA., Pirayesh E; Infectious Disease Research, Moderna, Inc., Cambridge, MA, USA., Lai YT; Infectious Disease Research, Moderna, Inc., Cambridge, MA, USA., Himansu S; Infectious Disease Research, Moderna, Inc., Cambridge, MA, USA., Carfi A; Infectious Disease Research, Moderna, Inc., Cambridge, MA, USA., Hu LT; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA., Mantis N; Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY, USA., Plante O; Infectious Disease Research, Moderna, Inc., Cambridge, MA, USA., Dold C; Infectious Disease Research, Moderna, Inc., Cambridge, MA, USA. Christina.Dold@modernatx.com.
Source: NPJ vaccines [NPJ Vaccines] 2026 May 05. Date of Electronic Publication: 2026 May 05.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature in partnership with the Sealy Center for Vaccine Development Country of Publication: England NLM ID: 101699863 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2059-0105 (Electronic) Linking ISSN: 20590105 NLM ISO Abbreviation: NPJ Vaccines
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  Data: Monovalent and multivalent OspA mRNA-LNP vaccines elicit functional antibodies and protect against Borrelia burgdorferi in mice.
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  Data: <searchLink fieldCode="AU" term="%22Finn+MB%22">Finn MB</searchLink>; Infectious Disease Research, Moderna, Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Willsey+G%22">Willsey G</searchLink>; Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY, USA.<br /><searchLink fieldCode="AU" term="%22Piazza+CL%22">Piazza CL</searchLink>; Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY, USA.<br /><searchLink fieldCode="AU" term="%22Clendenen+L%22">Clendenen L</searchLink>; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Shrestha+M%22">Shrestha M</searchLink>; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22You+SS%22">You SS</searchLink>; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ma+L%22">Ma L</searchLink>; Infectious Disease Research, Moderna, Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Dhingra+Y%22">Dhingra Y</searchLink>; Infectious Disease Research, Moderna, Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Laciak+AR%22">Laciak AR</searchLink>; Infectious Disease Research, Moderna, Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Uggowitzer+KA%22">Uggowitzer KA</searchLink>; Infectious Disease Research, Moderna, Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Obiero+JM%22">Obiero JM</searchLink>; Infectious Disease Research, Moderna, Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Freeman-Gallant+G%22">Freeman-Gallant G</searchLink>; Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY, USA.<br /><searchLink fieldCode="AU" term="%22Natarajan+H%22">Natarajan H</searchLink>; Infectious Disease Research, Moderna, Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Green+S%22">Green S</searchLink>; Infectious Disease Research, Moderna, Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Pirayesh+E%22">Pirayesh E</searchLink>; Infectious Disease Research, Moderna, Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lai+YT%22">Lai YT</searchLink>; Infectious Disease Research, Moderna, Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Himansu+S%22">Himansu S</searchLink>; Infectious Disease Research, Moderna, Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Carfi+A%22">Carfi A</searchLink>; Infectious Disease Research, Moderna, Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hu+LT%22">Hu LT</searchLink>; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Mantis+N%22">Mantis N</searchLink>; Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY, USA.<br /><searchLink fieldCode="AU" term="%22Plante+O%22">Plante O</searchLink>; Infectious Disease Research, Moderna, Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Dold+C%22">Dold C</searchLink>; Infectious Disease Research, Moderna, Inc., Cambridge, MA, USA. Christina.Dold@modernatx.com.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Nature+in+partnership+with+the+Sealy+Center+for+Vaccine+Development%22">Springer Nature in partnership with the Sealy Center for Vaccine Development </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101699863 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2059-0105 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220590105%22">20590105 </searchLink><i>NLM ISO Abbreviation: </i>NPJ Vaccines
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