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Case report of adult-type diffuse high-grade glioma IDH-wildtype subtype E with secondary spinal leptomeningeal dissemination, prolonged survival and literature review.

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Title: Case report of adult-type diffuse high-grade glioma IDH-wildtype subtype E with secondary spinal leptomeningeal dissemination, prolonged survival and literature review.
Authors: Meola A; AP-HM, Neuro-Oncology Department, University Hospital Timone, 264 Rue Saint Pierre, 13005, Marseille, France. Meola.adele@iuct-oncopole.fr.; Department of Oncology, Univ Toulouse, Oncopole Claudius Regaud, IUCT-Oncopole, Toulouse, France. Meola.adele@iuct-oncopole.fr., Appay R; Neuropathology Department University Hospital Timone, Aix Marseille University, 13005, Marseille, France., Testud B; APHM, Neuroradiology Department, University Hospital Timone, 13005, Marseille, France.; Aix Marseille University, CNRS, CRMBM, UMR 7339, Marseille, France.; APHM La Timone, CEMEREM, Marseille, France., Petrirena G; AP-HM, Neuro-Oncology Department, University Hospital Timone, 264 Rue Saint Pierre, 13005, Marseille, France., Campello C; AP-HM, Neuro-Oncology Department, University Hospital Timone, 264 Rue Saint Pierre, 13005, Marseille, France., Barrié M; AP-HM, Neuro-Oncology Department, University Hospital Timone, 264 Rue Saint Pierre, 13005, Marseille, France., Bertucci A; AP-HM, Neuro-Oncology Department, University Hospital Timone, 264 Rue Saint Pierre, 13005, Marseille, France.; Aix-Marseille University, CNRS, INP, Inst Neurophysiopathol, 13005, Marseille, France., Autran D; AP-HM, Neuro-Oncology Department, University Hospital Timone, 264 Rue Saint Pierre, 13005, Marseille, France., Graillon T; AP-HM, INSERM, MMG, Neurosurgery Department, Aix-Marseille University, University Hospital Timone, 13005, Marseille, France., Farah K; AP-HM, INSERM, MMG, Neurosurgery Department, Aix-Marseille University, University Hospital Timone, 13005, Marseille, France., Padovani L; AP-HM, Radiotherapy Department, Aix-Marseille University, University Hospital Timone, 13005, Marseille, France., Pougnet I; AP-HM, Radiotherapy Department, Aix-Marseille University, University Hospital Timone, 13005, Marseille, France., Nanni I; Oncobiology Department, Aix-Marseille University, University Hospital Timone, 13005, Marseille, France., Chinot O; AP-HM, Neuro-Oncology Department, University Hospital Timone, 264 Rue Saint Pierre, 13005, Marseille, France.; Aix-Marseille University, CNRS, INP, Inst Neurophysiopathol, 13005, Marseille, France., Tabouret E; AP-HM, Neuro-Oncology Department, University Hospital Timone, 264 Rue Saint Pierre, 13005, Marseille, France.; Aix-Marseille University, CNRS, INP, Inst Neurophysiopathol, 13005, Marseille, France.; Réseau Préclinique et Translationnel de Recherche en Neuro-Oncologie, Aix-Marseille Univ, Plateforme PE'TRANSLA', Marseille, France., Harlay V; AP-HM, Neuro-Oncology Department, University Hospital Timone, 264 Rue Saint Pierre, 13005, Marseille, France.
Source: Discover oncology [Discov Oncol] 2026 May 05; Vol. 17 (1). Date of Electronic Publication: 2026 May 05.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101775142 Publication Model: Electronic Cited Medium: Internet ISSN: 2730-6011 (Electronic) Linking ISSN: 27306011 NLM ISO Abbreviation: Discov Oncol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Case report of adult-type diffuse high-grade glioma IDH-wildtype subtype E with secondary spinal leptomeningeal dissemination, prolonged survival and literature review.
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  Data: <searchLink fieldCode="AU" term="%22Meola+A%22">Meola A</searchLink>; AP-HM, Neuro-Oncology Department, University Hospital Timone, 264 Rue Saint Pierre, 13005, Marseille, France. Meola.adele@iuct-oncopole.fr.; Department of Oncology, Univ Toulouse, Oncopole Claudius Regaud, IUCT-Oncopole, Toulouse, France. Meola.adele@iuct-oncopole.fr.<br /><searchLink fieldCode="AU" term="%22Appay+R%22">Appay R</searchLink>; Neuropathology Department University Hospital Timone, Aix Marseille University, 13005, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Testud+B%22">Testud B</searchLink>; APHM, Neuroradiology Department, University Hospital Timone, 13005, Marseille, France.; Aix Marseille University, CNRS, CRMBM, UMR 7339, Marseille, France.; APHM La Timone, CEMEREM, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Petrirena+G%22">Petrirena G</searchLink>; AP-HM, Neuro-Oncology Department, University Hospital Timone, 264 Rue Saint Pierre, 13005, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Campello+C%22">Campello C</searchLink>; AP-HM, Neuro-Oncology Department, University Hospital Timone, 264 Rue Saint Pierre, 13005, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Barrié+M%22">Barrié M</searchLink>; AP-HM, Neuro-Oncology Department, University Hospital Timone, 264 Rue Saint Pierre, 13005, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Bertucci+A%22">Bertucci A</searchLink>; AP-HM, Neuro-Oncology Department, University Hospital Timone, 264 Rue Saint Pierre, 13005, Marseille, France.; Aix-Marseille University, CNRS, INP, Inst Neurophysiopathol, 13005, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Autran+D%22">Autran D</searchLink>; AP-HM, Neuro-Oncology Department, University Hospital Timone, 264 Rue Saint Pierre, 13005, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Graillon+T%22">Graillon T</searchLink>; AP-HM, INSERM, MMG, Neurosurgery Department, Aix-Marseille University, University Hospital Timone, 13005, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Farah+K%22">Farah K</searchLink>; AP-HM, INSERM, MMG, Neurosurgery Department, Aix-Marseille University, University Hospital Timone, 13005, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Padovani+L%22">Padovani L</searchLink>; AP-HM, Radiotherapy Department, Aix-Marseille University, University Hospital Timone, 13005, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Pougnet+I%22">Pougnet I</searchLink>; AP-HM, Radiotherapy Department, Aix-Marseille University, University Hospital Timone, 13005, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Nanni+I%22">Nanni I</searchLink>; Oncobiology Department, Aix-Marseille University, University Hospital Timone, 13005, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Chinot+O%22">Chinot O</searchLink>; AP-HM, Neuro-Oncology Department, University Hospital Timone, 264 Rue Saint Pierre, 13005, Marseille, France.; Aix-Marseille University, CNRS, INP, Inst Neurophysiopathol, 13005, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Tabouret+E%22">Tabouret E</searchLink>; AP-HM, Neuro-Oncology Department, University Hospital Timone, 264 Rue Saint Pierre, 13005, Marseille, France.; Aix-Marseille University, CNRS, INP, Inst Neurophysiopathol, 13005, Marseille, France.; Réseau Préclinique et Translationnel de Recherche en Neuro-Oncologie, Aix-Marseille Univ, Plateforme PE'TRANSLA', Marseille, France.<br /><searchLink fieldCode="AU" term="%22Harlay+V%22">Harlay V</searchLink>; AP-HM, Neuro-Oncology Department, University Hospital Timone, 264 Rue Saint Pierre, 13005, Marseille, France.
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  Data: <searchLink fieldCode="JN" term="%22101775142%22">Discover oncology</searchLink> [Discov Oncol] 2026 May 05; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 May 05.
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