A novel combination for in vivo breast cancer treatment: TAK1 inhibition combined with metformin and Lentinula edodes compounds synergistically reinvigorates CD8+ T Cells.

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Title: A novel combination for in vivo breast cancer treatment: TAK1 inhibition combined with metformin and Lentinula edodes compounds synergistically reinvigorates CD8+ T Cells.
Authors: Mahdavi AS; Clinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran., Bagheri N; Cancer Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran., Marincola FM; Translational and Advanced Medicine (TAM) Biosciences, Nashville, TN, USA., Khosravian P; Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran., Ghatrehsamani M; Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, PO Box: 88155-571, Shahrekord, Iran. mahdi.samani.2020@gmail.com.
Source: Journal of translational medicine [J Transl Med] 2026 May 05; Vol. 24 (1). Date of Electronic Publication: 2026 May 05.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A novel combination for in vivo breast cancer treatment: TAK1 inhibition combined with metformin and Lentinula edodes compounds synergistically reinvigorates CD8<superscript>+</superscript> T Cells.
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  Data: <searchLink fieldCode="AU" term="%22Mahdavi+AS%22">Mahdavi AS</searchLink>; Clinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.<br /><searchLink fieldCode="AU" term="%22Bagheri+N%22">Bagheri N</searchLink>; Cancer Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.<br /><searchLink fieldCode="AU" term="%22Marincola+FM%22">Marincola FM</searchLink>; Translational and Advanced Medicine (TAM) Biosciences, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Khosravian+P%22">Khosravian P</searchLink>; Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.<br /><searchLink fieldCode="AU" term="%22Ghatrehsamani+M%22">Ghatrehsamani M</searchLink>; Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, PO Box: 88155-571, Shahrekord, Iran. mahdi.samani.2020@gmail.com.
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  Data: <searchLink fieldCode="JN" term="%22101190741%22">Journal of translational medicine</searchLink> [J Transl Med] 2026 May 05; Vol. 24 (1). <i>Date of Electronic Publication: </i>2026 May 05.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101190741 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1479-5876 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214795876%22">14795876 </searchLink><i>NLM ISO Abbreviation: </i>J Transl Med <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1186/s12967-026-07905-9
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      – Code: eng
        Text: English
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      – TitleFull: A novel combination for in vivo breast cancer treatment: TAK1 inhibition combined with metformin and Lentinula edodes compounds synergistically reinvigorates CD8+ T Cells.
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            NameFull: Mahdavi AS
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            NameFull: Bagheri N
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            NameFull: Marincola FM
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            – D: 05
              M: 05
              Text: 2026 May 05
              Type: published
              Y: 2026
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