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Micheliolide ameliorates colon cancer cachexia by modulating gut microbiota-immune signaling via Phocaeicola vulgatus enrichment.

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Title: Micheliolide ameliorates colon cancer cachexia by modulating gut microbiota-immune signaling via Phocaeicola vulgatus enrichment.
Authors: Youn HY; Center for Natural Product Efficacy Optimization, Natural Product Drug Development Division, Korea Institute of Science and Technology (KIST), 679 Saimdang-Ro, Gangneung, Gangwon-Do, Republic of Korea., Park S; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology (KIST), 679 Saimdang-Ro, Gangneung, Gangwon-Do, Republic of Korea., Min H; Center for Natural Product Efficacy Optimization, Natural Product Drug Development Division, Korea Institute of Science and Technology (KIST), 679 Saimdang-Ro, Gangneung, Gangwon-Do, Republic of Korea., Ngoc NB; Center for Natural Product Efficacy Optimization, Natural Product Drug Development Division, Korea Institute of Science and Technology (KIST), 679 Saimdang-Ro, Gangneung, Gangwon-Do, Republic of Korea., Kim YH; Center for Natural Product Efficacy Optimization, Natural Product Drug Development Division, Korea Institute of Science and Technology (KIST), 679 Saimdang-Ro, Gangneung, Gangwon-Do, Republic of Korea., Cha KH; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology (KIST), 679 Saimdang-Ro, Gangneung, Gangwon-Do, Republic of Korea.; Natural Product Applied Science, Korea Institute of Science and Technology (KIST) School, University of Science and Technology (UST), Gangneung, Gangwon-Do, Republic of Korea., Park YT; Center for Natural Product Efficacy Optimization, Natural Product Drug Development Division, Korea Institute of Science and Technology (KIST), 679 Saimdang-Ro, Gangneung, Gangwon-Do, Republic of Korea.; Natural Product Applied Science, Korea Institute of Science and Technology (KIST) School, University of Science and Technology (UST), Gangneung, Gangwon-Do, Republic of Korea., Kwon HY; Department of Integrated Biomedical Science, Soonchunhyang University, Cheonan, Chungcheongnam-Do, Republic of Korea., Lee CG; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology (KIST), 679 Saimdang-Ro, Gangneung, Gangwon-Do, Republic of Korea. cglee0708@kist.re.kr.; Natural Product Applied Science, Korea Institute of Science and Technology (KIST) School, University of Science and Technology (UST), Gangneung, Gangwon-Do, Republic of Korea. cglee0708@kist.re.kr., Kim M; Center for Natural Product Efficacy Optimization, Natural Product Drug Development Division, Korea Institute of Science and Technology (KIST), 679 Saimdang-Ro, Gangneung, Gangwon-Do, Republic of Korea. g-sstainer@kist.re.kr.; Natural Product Applied Science, Korea Institute of Science and Technology (KIST) School, University of Science and Technology (UST), Gangneung, Gangwon-Do, Republic of Korea. g-sstainer@kist.re.kr.; Department of Convergence Medicine, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-Do, Republic of Korea. g-sstainer@kist.re.kr.
Source: Microbiome [Microbiome] 2026 May 05; Vol. 14 (1). Date of Electronic Publication: 2026 May 05.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101615147 Publication Model: Electronic Cited Medium: Internet ISSN: 2049-2618 (Electronic) Linking ISSN: 20492618 NLM ISO Abbreviation: Microbiome Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Micheliolide ameliorates colon cancer cachexia by modulating gut microbiota-immune signaling via Phocaeicola vulgatus enrichment.
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  Data: <searchLink fieldCode="AU" term="%22Youn+HY%22">Youn HY</searchLink>; Center for Natural Product Efficacy Optimization, Natural Product Drug Development Division, Korea Institute of Science and Technology (KIST), 679 Saimdang-Ro, Gangneung, Gangwon-Do, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+S%22">Park S</searchLink>; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology (KIST), 679 Saimdang-Ro, Gangneung, Gangwon-Do, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Min+H%22">Min H</searchLink>; Center for Natural Product Efficacy Optimization, Natural Product Drug Development Division, Korea Institute of Science and Technology (KIST), 679 Saimdang-Ro, Gangneung, Gangwon-Do, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Ngoc+NB%22">Ngoc NB</searchLink>; Center for Natural Product Efficacy Optimization, Natural Product Drug Development Division, Korea Institute of Science and Technology (KIST), 679 Saimdang-Ro, Gangneung, Gangwon-Do, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+YH%22">Kim YH</searchLink>; Center for Natural Product Efficacy Optimization, Natural Product Drug Development Division, Korea Institute of Science and Technology (KIST), 679 Saimdang-Ro, Gangneung, Gangwon-Do, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Cha+KH%22">Cha KH</searchLink>; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology (KIST), 679 Saimdang-Ro, Gangneung, Gangwon-Do, Republic of Korea.; Natural Product Applied Science, Korea Institute of Science and Technology (KIST) School, University of Science and Technology (UST), Gangneung, Gangwon-Do, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+YT%22">Park YT</searchLink>; Center for Natural Product Efficacy Optimization, Natural Product Drug Development Division, Korea Institute of Science and Technology (KIST), 679 Saimdang-Ro, Gangneung, Gangwon-Do, Republic of Korea.; Natural Product Applied Science, Korea Institute of Science and Technology (KIST) School, University of Science and Technology (UST), Gangneung, Gangwon-Do, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kwon+HY%22">Kwon HY</searchLink>; Department of Integrated Biomedical Science, Soonchunhyang University, Cheonan, Chungcheongnam-Do, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+CG%22">Lee CG</searchLink>; Center for Natural Product Systems Biology, Natural Product Drug Development Division, Korea Institute of Science and Technology (KIST), 679 Saimdang-Ro, Gangneung, Gangwon-Do, Republic of Korea. cglee0708@kist.re.kr.; Natural Product Applied Science, Korea Institute of Science and Technology (KIST) School, University of Science and Technology (UST), Gangneung, Gangwon-Do, Republic of Korea. cglee0708@kist.re.kr.<br /><searchLink fieldCode="AU" term="%22Kim+M%22">Kim M</searchLink>; Center for Natural Product Efficacy Optimization, Natural Product Drug Development Division, Korea Institute of Science and Technology (KIST), 679 Saimdang-Ro, Gangneung, Gangwon-Do, Republic of Korea. g-sstainer@kist.re.kr.; Natural Product Applied Science, Korea Institute of Science and Technology (KIST) School, University of Science and Technology (UST), Gangneung, Gangwon-Do, Republic of Korea. g-sstainer@kist.re.kr.; Department of Convergence Medicine, Wonju College of Medicine, Yonsei University, Wonju, Gangwon-Do, Republic of Korea. g-sstainer@kist.re.kr.
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        Value: 10.1186/s40168-026-02412-x
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        Text: English
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      – TitleFull: Micheliolide ameliorates colon cancer cachexia by modulating gut microbiota-immune signaling via Phocaeicola vulgatus enrichment.
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              Text: 2026 May 05
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              Y: 2026
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