Targeting the integrated stress response or Ataxin-2 alleviates neurodegeneration in PolyGR models of C9orf72 associated frontotemporal dementia and amyotrophic lateral sclerosis.
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| Title: | Targeting the integrated stress response or Ataxin-2 alleviates neurodegeneration in PolyGR models of C9orf72 associated frontotemporal dementia and amyotrophic lateral sclerosis. |
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| Authors: | Harper NS; Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Sharpe JL; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK.; Neuroscience Institute, University of Sheffield, Sheffield, S10 2TN, UK., Speranza J; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK.; Neuroscience Institute, University of Sheffield, Sheffield, S10 2TN, UK., Gulia R; Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, 92617, USA., Chen JX; Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, 92617, USA., Allen SP; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK.; Neuroscience Institute, University of Sheffield, Sheffield, S10 2TN, UK., Atwal MS; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK.; Neuroscience Institute, University of Sheffield, Sheffield, S10 2TN, UK., Pickering-Brown S; Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Livesey MR; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK.; Neuroscience Institute, University of Sheffield, Sheffield, S10 2TN, UK., Bennett CL; Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, 92617, USA.; UCI Center for Neurotherapeutics, University of California, Irvine, Irvine, CA, 92697, USA., Prokop A; Division of Molecular and Cellular Function, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK., La Spada AR; Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, 92617, USA.; UCI Center for Neurotherapeutics, University of California, Irvine, Irvine, CA, 92697, USA.; Department of Biological Chemistry, University of California, Irvine, Irvine, CA, 92617, USA.; Department of Neurology, University of California, Irvine, Irvine, CA, 92617, USA.; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, 92697, USA., West RJH; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK. r.j.west@sheffield.ac.uk.; Neuroscience Institute, University of Sheffield, Sheffield, S10 2TN, UK. r.j.west@sheffield.ac.uk. |
| Source: | Acta neuropathologica communications [Acta Neuropathol Commun] 2026 May 05; Vol. 14 (1). Date of Electronic Publication: 2026 May 05. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42087256 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Targeting the integrated stress response or Ataxin-2 alleviates neurodegeneration in PolyGR models of C9orf72 associated frontotemporal dementia and amyotrophic lateral sclerosis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Harper+NS%22">Harper NS</searchLink>; Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Sharpe+JL%22">Sharpe JL</searchLink>; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK.; Neuroscience Institute, University of Sheffield, Sheffield, S10 2TN, UK.<br /><searchLink fieldCode="AU" term="%22Speranza+J%22">Speranza J</searchLink>; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK.; Neuroscience Institute, University of Sheffield, Sheffield, S10 2TN, UK.<br /><searchLink fieldCode="AU" term="%22Gulia+R%22">Gulia R</searchLink>; Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, 92617, USA.<br /><searchLink fieldCode="AU" term="%22Chen+JX%22">Chen JX</searchLink>; Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, 92617, USA.<br /><searchLink fieldCode="AU" term="%22Allen+SP%22">Allen SP</searchLink>; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK.; Neuroscience Institute, University of Sheffield, Sheffield, S10 2TN, UK.<br /><searchLink fieldCode="AU" term="%22Atwal+MS%22">Atwal MS</searchLink>; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK.; Neuroscience Institute, University of Sheffield, Sheffield, S10 2TN, UK.<br /><searchLink fieldCode="AU" term="%22Pickering-Brown+S%22">Pickering-Brown S</searchLink>; Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Livesey+MR%22">Livesey MR</searchLink>; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK.; Neuroscience Institute, University of Sheffield, Sheffield, S10 2TN, UK.<br /><searchLink fieldCode="AU" term="%22Bennett+CL%22">Bennett CL</searchLink>; Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, 92617, USA.; UCI Center for Neurotherapeutics, University of California, Irvine, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22Prokop+A%22">Prokop A</searchLink>; Division of Molecular and Cellular Function, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22La+Spada+AR%22">La Spada AR</searchLink>; Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, 92617, USA.; UCI Center for Neurotherapeutics, University of California, Irvine, Irvine, CA, 92697, USA.; Department of Biological Chemistry, University of California, Irvine, Irvine, CA, 92617, USA.; Department of Neurology, University of California, Irvine, Irvine, CA, 92617, USA.; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, 92697, USA.<br /><searchLink fieldCode="AU" term="%22West+RJH%22">West RJH</searchLink>; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK. r.j.west@sheffield.ac.uk.; Neuroscience Institute, University of Sheffield, Sheffield, S10 2TN, UK. r.j.west@sheffield.ac.uk. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101610673%22">Acta neuropathologica communications</searchLink> [Acta Neuropathol Commun] 2026 May 05; Vol. 14 (1). <i>Date of Electronic Publication: </i>2026 May 05. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101610673 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2051-5960 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220515960%22">20515960 </searchLink><i>NLM ISO Abbreviation: </i>Acta Neuropathol Commun <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42087256 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1186/s40478-026-02301-2 Languages: – Code: eng Text: English Titles: – TitleFull: Targeting the integrated stress response or Ataxin-2 alleviates neurodegeneration in PolyGR models of C9orf72 associated frontotemporal dementia and amyotrophic lateral sclerosis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Harper NS – PersonEntity: Name: NameFull: Sharpe JL – PersonEntity: Name: NameFull: Speranza J – PersonEntity: Name: NameFull: Gulia R – PersonEntity: Name: NameFull: Chen JX – PersonEntity: Name: NameFull: Allen SP – PersonEntity: Name: NameFull: Atwal MS – PersonEntity: Name: NameFull: Pickering-Brown S – PersonEntity: Name: NameFull: Livesey MR – PersonEntity: Name: NameFull: Bennett CL – PersonEntity: Name: NameFull: Prokop A – PersonEntity: Name: NameFull: La Spada AR – PersonEntity: Name: NameFull: West RJH IsPartOfRelationships: – BibEntity: Dates: – D: 05 M: 05 Text: 2026 May 05 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2051-5960 Numbering: – Type: volume Value: 14 – Type: issue Value: 1 Titles: – TitleFull: Acta neuropathologica communications Type: main |
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