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Efficient gene disruption with CRISPR-Cas3 in human T cells.

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Title: Efficient gene disruption with CRISPR-Cas3 in human T cells.
Authors: Fujii T; Division of Animal Genetics, Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan., Sakoda Y; Department of Immunology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube 755-8505, Japan.; Research Institute for Cell Design Medical Science, 1-1-1 Minami-Kogushi, Ube 755-8505, Japan., Yoshimi K; Division of Animal Genetics, Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.; Division of Genome Engineering, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan., Takeshita K; Advanced Photon Technology Division, RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148, Japan., Watanabe S; Division of Animal Genetics, Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan., Iida R; Division of Animal Genetics, Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan., Obo T; Division of Animal Genetics, Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan., Yokoyama K; Division of Animal Genetics, Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan., Tamada K; Department of Immunology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube 755-8505, Japan.; Research Institute for Cell Design Medical Science, 1-1-1 Minami-Kogushi, Ube 755-8505, Japan., Mashimo T; Division of Animal Genetics, Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.; Division of Genome Engineering, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
Source: NAR cancer [NAR Cancer] 2026 Apr 21; Vol. 8 (2), pp. zcag009. Date of Electronic Publication: 2026 Apr 21 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 101769553 Publication Model: eCollection Cited Medium: Internet ISSN: 2632-8674 (Electronic) Linking ISSN: 26328674 NLM ISO Abbreviation: NAR Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Efficient gene disruption with CRISPR-Cas3 in human T cells.
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  Data: <searchLink fieldCode="AU" term="%22Fujii+T%22">Fujii T</searchLink>; Division of Animal Genetics, Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.<br /><searchLink fieldCode="AU" term="%22Sakoda+Y%22">Sakoda Y</searchLink>; Department of Immunology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube 755-8505, Japan.; Research Institute for Cell Design Medical Science, 1-1-1 Minami-Kogushi, Ube 755-8505, Japan.<br /><searchLink fieldCode="AU" term="%22Yoshimi+K%22">Yoshimi K</searchLink>; Division of Animal Genetics, Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.; Division of Genome Engineering, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.<br /><searchLink fieldCode="AU" term="%22Takeshita+K%22">Takeshita K</searchLink>; Advanced Photon Technology Division, RIKEN SPring-8 Center, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148, Japan.<br /><searchLink fieldCode="AU" term="%22Watanabe+S%22">Watanabe S</searchLink>; Division of Animal Genetics, Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.<br /><searchLink fieldCode="AU" term="%22Iida+R%22">Iida R</searchLink>; Division of Animal Genetics, Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.<br /><searchLink fieldCode="AU" term="%22Obo+T%22">Obo T</searchLink>; Division of Animal Genetics, Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.<br /><searchLink fieldCode="AU" term="%22Yokoyama+K%22">Yokoyama K</searchLink>; Division of Animal Genetics, Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.<br /><searchLink fieldCode="AU" term="%22Tamada+K%22">Tamada K</searchLink>; Department of Immunology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube 755-8505, Japan.; Research Institute for Cell Design Medical Science, 1-1-1 Minami-Kogushi, Ube 755-8505, Japan.<br /><searchLink fieldCode="AU" term="%22Mashimo+T%22">Mashimo T</searchLink>; Division of Animal Genetics, Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.; Division of Genome Engineering, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
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        Value: 10.1093/narcan/zcag009
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              Text: 2026 Apr 21
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