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Metabolomic investigation of cisplatin-induced acute kidney injury in paediatric cancer patients.

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Title: Metabolomic investigation of cisplatin-induced acute kidney injury in paediatric cancer patients.
Authors: Lim YJ; Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada., Thachil A; Division of Nephrology, Department of Pediatrics, British Columbia Children's Hospital, Vancouver, British Columbia, Canada., McMahon K; Department of Pediatrics, Division of Nephrology, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada., Tsuyuki RT; Epicore Center, Department of Medicine, Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada., Rassekh SR; Division of Oncology, Hematology and Bone Marrow Transplant, Department of Pediatrics, Faculty of Medicine, BC Children's Hospital and University of British Columbia, Vancouver, Canada., Mitchell LG; Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada., Devarajan P; Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Mammen C; Division of Nephrology, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada., Carleton BC; Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Cuvelier GDE; Alberta Children's Hospital, University of Calgary, Calgary, Alberta, Canada., Lewis VA; Pediatric Oncology and Transplant, Alberta Children's Hospital, University of Calgary, Calgary, Alberta, Canada., Ross CJD; Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada., Zorzi AP; Division of Pediatric Hematology-Oncology, Children's Hospital London Health Sciences Centre, London, Ontario, Canada., Baruchel S; Translational Medicine, The Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario, Canada., Ramphal R; Division of Hematology and Oncology, Department of Pediatrics, Children's Hospital of Eastern Ontario-Ottawa Children's Treatment Centre, Ottawa, Ontario, Canada., Bouffet E; Division of Nephrology, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada., Lemaire M; Division of Nephrology, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada., Blydt-Hansen TD; Division of Nephrology, Department of Pediatrics, British Columbia Children's Hospital, Vancouver, British Columbia, Canada., Urquhart BL; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.; Division of Nephrology, Department of Medicine, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
Corporate Authors: Applying Biomarkers to Minimize Long‐Term Effects of Childhood/Adolescent Cancer Treatment (ABLE) Research Study Group
Source: British journal of clinical pharmacology [Br J Clin Pharmacol] 2026 May 06, pp. e70587. Date of Electronic Publication: 2026 May 06.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 7503323 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2125 (Electronic) Linking ISSN: 03065251 NLM ISO Abbreviation: Br J Clin Pharmacol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Lim+YJ%22">Lim YJ</searchLink>; Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Thachil+A%22">Thachil A</searchLink>; Division of Nephrology, Department of Pediatrics, British Columbia Children's Hospital, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22McMahon+K%22">McMahon K</searchLink>; Department of Pediatrics, Division of Nephrology, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Tsuyuki+RT%22">Tsuyuki RT</searchLink>; Epicore Center, Department of Medicine, Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Rassekh+SR%22">Rassekh SR</searchLink>; Division of Oncology, Hematology and Bone Marrow Transplant, Department of Pediatrics, Faculty of Medicine, BC Children's Hospital and University of British Columbia, Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Mitchell+LG%22">Mitchell LG</searchLink>; Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Devarajan+P%22">Devarajan P</searchLink>; Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Mammen+C%22">Mammen C</searchLink>; Division of Nephrology, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Carleton+BC%22">Carleton BC</searchLink>; Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Cuvelier+GDE%22">Cuvelier GDE</searchLink>; Alberta Children's Hospital, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Lewis+VA%22">Lewis VA</searchLink>; Pediatric Oncology and Transplant, Alberta Children's Hospital, University of Calgary, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Ross+CJD%22">Ross CJD</searchLink>; Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Zorzi+AP%22">Zorzi AP</searchLink>; Division of Pediatric Hematology-Oncology, Children's Hospital London Health Sciences Centre, London, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Baruchel+S%22">Baruchel S</searchLink>; Translational Medicine, The Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Ramphal+R%22">Ramphal R</searchLink>; Division of Hematology and Oncology, Department of Pediatrics, Children's Hospital of Eastern Ontario-Ottawa Children's Treatment Centre, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Bouffet+E%22">Bouffet E</searchLink>; Division of Nephrology, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Lemaire+M%22">Lemaire M</searchLink>; Division of Nephrology, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Blydt-Hansen+TD%22">Blydt-Hansen TD</searchLink>; Division of Nephrology, Department of Pediatrics, British Columbia Children's Hospital, Vancouver, British Columbia, Canada.<br /><searchLink fieldCode="AU" term="%22Urquhart+BL%22">Urquhart BL</searchLink>; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.; Division of Nephrology, Department of Medicine, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.
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  Data: <searchLink fieldCode="JN" term="%227503323%22">British journal of clinical pharmacology</searchLink> [Br J Clin Pharmacol] 2026 May 06, pp. e70587. <i>Date of Electronic Publication: </i>2026 May 06.
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