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Lactate transport inhibition therapeutically reprograms fibroblast metabolism in experimental pulmonary fibrosis.

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Title: Lactate transport inhibition therapeutically reprograms fibroblast metabolism in experimental pulmonary fibrosis.
Authors: Ziehr DR; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Li F; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.; Department of Medicine, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA., Parnell KM; Vettore Biosciences, San Francisco, CA 94158, USA., Krah NM; Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112, USA.; Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA., Leahy KJ; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Guillermier C; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Gao C; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Prell SA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Vigder N; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.; School of Life and Environmental Sciences, Faculty of Science, University of Sydney, Sydney, NSW 2006, Australia., Poli S; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Varon J; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Baron RM; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Maron BA; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.; University of Maryland Institute for Health Computing, Bethesda, MD 20814, USA., Philp NJ; Department of Pathology and Genomic Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA., Hariri LP; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA., Kim EY; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Wei KS; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Steinhauser ML; Aging Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA.; UPMC Heart and Vascular Institute, UPMC Presbyterian, Pittsburgh, PA 15213, USA., Knipe RS; Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Rutter J; Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.; Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City, UT 84112, USA., Oldham WM; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.; Department of Medicine, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA.
Source: Science translational medicine [Sci Transl Med] 2026 May 06; Vol. 18 (848), pp. eads2673. Date of Electronic Publication: 2026 May 06.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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