TCF3::HLF orchestrates an enhancer-promoter network with activation of MEF2C to promote immature HSC gene expression in leukemia.

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Title: TCF3::HLF orchestrates an enhancer-promoter network with activation of MEF2C to promote immature HSC gene expression in leukemia.
Authors: Priebe V; Division of Oncology and Children's Research Centre, University Children's Hospital Zurich, Zurich, Switzerland.; Department of Molecular Mechanism of Disease, University of Zurich, Zurich, Switzerland., Galvan B; Division of Oncology and Children's Research Centre, University Children's Hospital Zurich, Zurich, Switzerland., Drakul A; Division of Oncology and Children's Research Centre, University Children's Hospital Zurich, Zurich, Switzerland., Margelisch N; Division of Oncology and Children's Research Centre, University Children's Hospital Zurich, Zurich, Switzerland., Aguadé-Gorgorió J; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, USA.; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA, USA., Walavalkar K; Department of Molecular Mechanism of Disease, University of Zurich, Zurich, Switzerland., Huang Y; Division of Oncology and Children's Research Centre, University Children's Hospital Zurich, Zurich, Switzerland., Mikkola HKA; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, USA.; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA.; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA., Bornhauser B; Division of Oncology and Children's Research Centre, University Children's Hospital Zurich, Zurich, Switzerland., Santoro R; Department of Molecular Mechanism of Disease, University of Zurich, Zurich, Switzerland., Bourquin JP; Division of Oncology and Children's Research Centre, University Children's Hospital Zurich, Zurich, Switzerland.
Source: Science advances [Sci Adv] 2026 May 08; Vol. 12 (19), pp. eadu3728. Date of Electronic Publication: 2026 May 08.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: TCF3::HLF orchestrates an enhancer-promoter network with activation of MEF2C to promote immature HSC gene expression in leukemia.
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  Data: <searchLink fieldCode="AU" term="%22Priebe+V%22">Priebe V</searchLink>; Division of Oncology and Children's Research Centre, University Children's Hospital Zurich, Zurich, Switzerland.; Department of Molecular Mechanism of Disease, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Galvan+B%22">Galvan B</searchLink>; Division of Oncology and Children's Research Centre, University Children's Hospital Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Drakul+A%22">Drakul A</searchLink>; Division of Oncology and Children's Research Centre, University Children's Hospital Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Margelisch+N%22">Margelisch N</searchLink>; Division of Oncology and Children's Research Centre, University Children's Hospital Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Aguadé-Gorgorió+J%22">Aguadé-Gorgorió J</searchLink>; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, USA.; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Walavalkar+K%22">Walavalkar K</searchLink>; Department of Molecular Mechanism of Disease, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; Division of Oncology and Children's Research Centre, University Children's Hospital Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mikkola+HKA%22">Mikkola HKA</searchLink>; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, USA.; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA.; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bornhauser+B%22">Bornhauser B</searchLink>; Division of Oncology and Children's Research Centre, University Children's Hospital Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Santoro+R%22">Santoro R</searchLink>; Department of Molecular Mechanism of Disease, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bourquin+JP%22">Bourquin JP</searchLink>; Division of Oncology and Children's Research Centre, University Children's Hospital Zurich, Zurich, Switzerland.
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  Data: <searchLink fieldCode="JN" term="%22101653440%22">Science advances</searchLink> [Sci Adv] 2026 May 08; Vol. 12 (19), pp. eadu3728. <i>Date of Electronic Publication: </i>2026 May 08.
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