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A sensitive LC‑MS/MS method for the simultaneous quantification of hexosylceramides and hexosylsphingosines, their precursors and metabolites in cells, plasma, and tissue homogenates.

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Title: A sensitive LC‑MS/MS method for the simultaneous quantification of hexosylceramides and hexosylsphingosines, their precursors and metabolites in cells, plasma, and tissue homogenates.
Authors: Iannone M; Johnson&Johnson, Neuroscience Discovery, Beerse, Belgium.; Philip Morris R&D, Quai Jeanrenaud 5, 2000, Neuchatel, Switzerland., Loomans T; Johnson&Johnson, Preclinical Sciences & Translational Safety, Beerse, Belgium., Gorremans S; Johnson&Johnson, Neuroscience Discovery, Beerse, Belgium., Grajchen E; Johnson&Johnson, Neuroscience Discovery, Beerse, Belgium., Deneubourg C; Johnson&Johnson, Neuroscience Discovery, Beerse, Belgium., Hrupka B; Johnson&Johnson, Neuroscience Discovery, Beerse, Belgium., Ver Donck L; Johnson&Johnson, Neuroscience Discovery, Beerse, Belgium., Bretteville A; Johnson&Johnson, Neuroscience Discovery, Beerse, Belgium., Moechars D; Johnson&Johnson, Neuroscience Discovery, Beerse, Belgium., Vreeken RJ; Johnson&Johnson, Preclinical Sciences & Translational Safety, Beerse, Belgium.; Maastricht MultiModal Molecular Imaging Institute (M4I), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.; TNO, Health & Work, Sylviusweg 71, 2333 BE, Leiden, the Netherlands., Jahouh F; Johnson&Johnson, Preclinical Sciences & Translational Safety, Beerse, Belgium. fjahouh@its.jnj.com.
Source: Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2026 Jun; Vol. 418 (12), pp. 3791-3806. Date of Electronic Publication: 2026 May 07.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 101134327 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-2650 (Electronic) Linking ISSN: 16182642 NLM ISO Abbreviation: Anal Bioanal Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A sensitive LC‑MS/MS method for the simultaneous quantification of hexosylceramides and hexosylsphingosines, their precursors and metabolites in cells, plasma, and tissue homogenates.
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  Data: <searchLink fieldCode="AU" term="%22Iannone+M%22">Iannone M</searchLink>; Johnson&Johnson, Neuroscience Discovery, Beerse, Belgium.; Philip Morris R&D, Quai Jeanrenaud 5, 2000, Neuchatel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Loomans+T%22">Loomans T</searchLink>; Johnson&Johnson, Preclinical Sciences & Translational Safety, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Gorremans+S%22">Gorremans S</searchLink>; Johnson&Johnson, Neuroscience Discovery, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Grajchen+E%22">Grajchen E</searchLink>; Johnson&Johnson, Neuroscience Discovery, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Deneubourg+C%22">Deneubourg C</searchLink>; Johnson&Johnson, Neuroscience Discovery, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Hrupka+B%22">Hrupka B</searchLink>; Johnson&Johnson, Neuroscience Discovery, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Ver+Donck+L%22">Ver Donck L</searchLink>; Johnson&Johnson, Neuroscience Discovery, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Bretteville+A%22">Bretteville A</searchLink>; Johnson&Johnson, Neuroscience Discovery, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Moechars+D%22">Moechars D</searchLink>; Johnson&Johnson, Neuroscience Discovery, Beerse, Belgium.<br /><searchLink fieldCode="AU" term="%22Vreeken+RJ%22">Vreeken RJ</searchLink>; Johnson&Johnson, Preclinical Sciences & Translational Safety, Beerse, Belgium.; Maastricht MultiModal Molecular Imaging Institute (M4I), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.; TNO, Health & Work, Sylviusweg 71, 2333 BE, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Jahouh+F%22">Jahouh F</searchLink>; Johnson&Johnson, Preclinical Sciences & Translational Safety, Beerse, Belgium. fjahouh@its.jnj.com.
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  Data: <searchLink fieldCode="JN" term="%22101134327%22">Analytical and bioanalytical chemistry</searchLink> [Anal Bioanal Chem] 2026 Jun; Vol. 418 (12), pp. 3791-3806. <i>Date of Electronic Publication: </i>2026 May 07.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer-Verlag%22">Springer-Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>101134327 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1618-2650 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216182642%22">16182642 </searchLink><i>NLM ISO Abbreviation: </i>Anal Bioanal Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s00216-026-06485-3
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              Text: 2026 Jun
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