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Serum neurofilament light chain (sNFL) as a predictive biomarker for Chemotherapy-induced peripheral neurotoxicity (CIPN): consideration of current evidence, validation steps, and barriers to CIPN biomarker implementation in clinical practice-a narrative review.

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Title: Serum neurofilament light chain (sNFL) as a predictive biomarker for Chemotherapy-induced peripheral neurotoxicity (CIPN): consideration of current evidence, validation steps, and barriers to CIPN biomarker implementation in clinical practice-a narrative review.
Authors: Alberti P; School of Medicine & Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, Italy., Faithfull S; Discipline of Radiation Therapy, School of Medicine, Trinity College Dublin, The University of Dublin, Dublin, Ireland., Argyriou AA; Department of Neurology, 'Agios Andreas' General Hospital of Patras, Kalavriton 37 Str, 26335, Patras, Greece., Balayssac D; Direction de la Recherche Clinique et de l'Innovation (DRCI), CHU Clermont-Ferrand (Clermont-Ferrand University Hospital), Clermont-Ferrand, France.; NEURO-DOL, Université Clermont Auvergne, INSERM, UMR 1107 / U1107, Clermont-Ferrand, France., Hertz DL; College of Pharmacy, University of Michigan, 428 Church St, Ann Arbor, MI, 48109-1065, USA., Lustberg M; Yale School of Medicine, 333 Cedar St, New Haven, CT, 06510, USA., Park SB; Faculty of Medicine and Health, School of Medical Sciences and Brain and Mind Centre, University of Sydney, Camperdown, NSW, 2050, Australia., Li T; Faculty of Medicine and Health, School of Medical Sciences and Brain and Mind Centre, University of Sydney, Camperdown, NSW, 2050, Australia., Tanay M; Berkshire Cancer Centre, Royal Berkshire NHS Trust, Reading, UK., Jabaley T; Dana-Farber Cancer Institute, 450 Brookline Avenue, BP 1140L, Boston, MA, 02215, USA., Worthen-Chaudhari L; Department of Physical Medicine and Rehabilitation, Dodd Rehabilitation Hospital, The Ohio State University College of Medicine, Colombus, OH, 43210, USA., Smith EML; Department of Acute, Chronic & Continuing Care, The University of Alabama at Birmingham School of Nursing, 2101 Magnolia Avenue, Room 225, Birmingham, AL, 35205, USA. esmith3@uab.edu.
Corporate Authors: MASCC Neurological complications study group
Source: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2026 May 07; Vol. 34 (6). Date of Electronic Publication: 2026 May 07.
Publication Type: Journal Article; Review
Journal Info: Publisher: Springer International Country of Publication: Germany NLM ID: 9302957 Publication Model: Electronic Cited Medium: Internet ISSN: 1433-7339 (Electronic) Linking ISSN: 09414355 NLM ISO Abbreviation: Support Care Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Serum neurofilament light chain (sNFL) as a predictive biomarker for Chemotherapy-induced peripheral neurotoxicity (CIPN): consideration of current evidence, validation steps, and barriers to CIPN biomarker implementation in clinical practice-a narrative review.
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  Data: <searchLink fieldCode="AU" term="%22Alberti+P%22">Alberti P</searchLink>; School of Medicine & Surgery, University of Milano-Bicocca, Via Cadore 48, 20900, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Faithfull+S%22">Faithfull S</searchLink>; Discipline of Radiation Therapy, School of Medicine, Trinity College Dublin, The University of Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Argyriou+AA%22">Argyriou AA</searchLink>; Department of Neurology, 'Agios Andreas' General Hospital of Patras, Kalavriton 37 Str, 26335, Patras, Greece.<br /><searchLink fieldCode="AU" term="%22Balayssac+D%22">Balayssac D</searchLink>; Direction de la Recherche Clinique et de l'Innovation (DRCI), CHU Clermont-Ferrand (Clermont-Ferrand University Hospital), Clermont-Ferrand, France.; NEURO-DOL, Université Clermont Auvergne, INSERM, UMR 1107 / U1107, Clermont-Ferrand, France.<br /><searchLink fieldCode="AU" term="%22Hertz+DL%22">Hertz DL</searchLink>; College of Pharmacy, University of Michigan, 428 Church St, Ann Arbor, MI, 48109-1065, USA.<br /><searchLink fieldCode="AU" term="%22Lustberg+M%22">Lustberg M</searchLink>; Yale School of Medicine, 333 Cedar St, New Haven, CT, 06510, USA.<br /><searchLink fieldCode="AU" term="%22Park+SB%22">Park SB</searchLink>; Faculty of Medicine and Health, School of Medical Sciences and Brain and Mind Centre, University of Sydney, Camperdown, NSW, 2050, Australia.<br /><searchLink fieldCode="AU" term="%22Li+T%22">Li T</searchLink>; Faculty of Medicine and Health, School of Medical Sciences and Brain and Mind Centre, University of Sydney, Camperdown, NSW, 2050, Australia.<br /><searchLink fieldCode="AU" term="%22Tanay+M%22">Tanay M</searchLink>; Berkshire Cancer Centre, Royal Berkshire NHS Trust, Reading, UK.<br /><searchLink fieldCode="AU" term="%22Jabaley+T%22">Jabaley T</searchLink>; Dana-Farber Cancer Institute, 450 Brookline Avenue, BP 1140L, Boston, MA, 02215, USA.<br /><searchLink fieldCode="AU" term="%22Worthen-Chaudhari+L%22">Worthen-Chaudhari L</searchLink>; Department of Physical Medicine and Rehabilitation, Dodd Rehabilitation Hospital, The Ohio State University College of Medicine, Colombus, OH, 43210, USA.<br /><searchLink fieldCode="AU" term="%22Smith+EML%22">Smith EML</searchLink>; Department of Acute, Chronic & Continuing Care, The University of Alabama at Birmingham School of Nursing, 2101 Magnolia Avenue, Room 225, Birmingham, AL, 35205, USA. esmith3@uab.edu.
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      – TitleFull: Serum neurofilament light chain (sNFL) as a predictive biomarker for Chemotherapy-induced peripheral neurotoxicity (CIPN): consideration of current evidence, validation steps, and barriers to CIPN biomarker implementation in clinical practice-a narrative review.
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