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Evaluating the Utility and Constraints of the Competitive Counter Flow (CCF) Assay in OATP1B1 Substrate Profiling.

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Title: Evaluating the Utility and Constraints of the Competitive Counter Flow (CCF) Assay in OATP1B1 Substrate Profiling.
Authors: Mathialagan S; Pharmacokinetics, Dynamics and Metabolism, ADME Sciences, Pfizer Inc, Groton, Connecticut, USA., West MA; Pharmacokinetics, Dynamics and Metabolism, ADME Sciences, Pfizer Inc, Groton, Connecticut, USA., Yamaguchi E; Pharmacokinetics, Dynamics and Metabolism, ADME Sciences, Pfizer Inc, Groton, Connecticut, USA., Moulton HM; Pharmacokinetics, Dynamics and Metabolism, ADME Sciences, Pfizer Inc, Groton, Connecticut, USA., Kapinos B; Pharmacokinetics, Dynamics and Metabolism, ADME Sciences, Pfizer Inc, Groton, Connecticut, USA., Paryad Zanjani S; Pharmacokinetics, Dynamics and Metabolism, ADME Sciences, Pfizer Inc, Groton, Connecticut, USA., Tess DA; Pharmacokinetics, Dynamics and Metabolism, ADME Sciences, Pfizer Inc, Cambridge, Massachusetts , USA., Kimoto E; Pharmacokinetics, Dynamics and Metabolism, ADME Sciences, Pfizer Inc, Groton, Connecticut, USA., Varma MVS; Pharmacokinetics, Dynamics and Metabolism, ADME Sciences, Pfizer Inc, Groton, Connecticut, USA., Yee SW; Pharmacokinetics, Dynamics and Metabolism, ADME Sciences, Pfizer Inc, Groton, Connecticut, USA. sookwah.yee@pfizer.com.
Source: The AAPS journal [AAPS J] 2026 May 06; Vol. 28 (3). Date of Electronic Publication: 2026 May 06.
Publication Type: Journal Article
Journal Info: Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication Model: Electronic Cited Medium: Internet ISSN: 1550-7416 (Electronic) Linking ISSN: 15507416 NLM ISO Abbreviation: AAPS J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Evaluating the Utility and Constraints of the Competitive Counter Flow (CCF) Assay in OATP1B1 Substrate Profiling.
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  Data: <searchLink fieldCode="AU" term="%22Mathialagan+S%22">Mathialagan S</searchLink>; Pharmacokinetics, Dynamics and Metabolism, ADME Sciences, Pfizer Inc, Groton, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22West+MA%22">West MA</searchLink>; Pharmacokinetics, Dynamics and Metabolism, ADME Sciences, Pfizer Inc, Groton, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Yamaguchi+E%22">Yamaguchi E</searchLink>; Pharmacokinetics, Dynamics and Metabolism, ADME Sciences, Pfizer Inc, Groton, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Moulton+HM%22">Moulton HM</searchLink>; Pharmacokinetics, Dynamics and Metabolism, ADME Sciences, Pfizer Inc, Groton, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Kapinos+B%22">Kapinos B</searchLink>; Pharmacokinetics, Dynamics and Metabolism, ADME Sciences, Pfizer Inc, Groton, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Paryad+Zanjani+S%22">Paryad Zanjani S</searchLink>; Pharmacokinetics, Dynamics and Metabolism, ADME Sciences, Pfizer Inc, Groton, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Tess+DA%22">Tess DA</searchLink>; Pharmacokinetics, Dynamics and Metabolism, ADME Sciences, Pfizer Inc, Cambridge, Massachusetts , USA.<br /><searchLink fieldCode="AU" term="%22Kimoto+E%22">Kimoto E</searchLink>; Pharmacokinetics, Dynamics and Metabolism, ADME Sciences, Pfizer Inc, Groton, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Varma+MVS%22">Varma MVS</searchLink>; Pharmacokinetics, Dynamics and Metabolism, ADME Sciences, Pfizer Inc, Groton, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Yee+SW%22">Yee SW</searchLink>; Pharmacokinetics, Dynamics and Metabolism, ADME Sciences, Pfizer Inc, Groton, Connecticut, USA. sookwah.yee@pfizer.com.
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  Data: <searchLink fieldCode="JN" term="%22101223209%22">The AAPS journal</searchLink> [AAPS J] 2026 May 06; Vol. 28 (3). <i>Date of Electronic Publication: </i>2026 May 06.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+of+Pharmaceutical+Scientists%22">American Association of Pharmaceutical Scientists </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101223209 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1550-7416 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215507416%22">15507416 </searchLink><i>NLM ISO Abbreviation: </i>AAPS J <i>Subsets: </i>MEDLINE
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        Value: 10.1208/s12248-026-01251-w
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        Text: English
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      – TitleFull: Evaluating the Utility and Constraints of the Competitive Counter Flow (CCF) Assay in OATP1B1 Substrate Profiling.
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              Text: 2026 May 06
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