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Evaluating the Utility and Constraints of the Competitive Counter Flow (CCF) Assay in OATP1B1 Substrate Profiling.

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Title: Evaluating the Utility and Constraints of the Competitive Counter Flow (CCF) Assay in OATP1B1 Substrate Profiling.
Authors: Mathialagan S; Pharmacokinetics, Dynamics and Metabolism, ADME Sciences, Pfizer Inc, Groton, Connecticut, USA., West MA; Pharmacokinetics, Dynamics and Metabolism, ADME Sciences, Pfizer Inc, Groton, Connecticut, USA., Yamaguchi E; Pharmacokinetics, Dynamics and Metabolism, ADME Sciences, Pfizer Inc, Groton, Connecticut, USA., Moulton HM; Pharmacokinetics, Dynamics and Metabolism, ADME Sciences, Pfizer Inc, Groton, Connecticut, USA., Kapinos B; Pharmacokinetics, Dynamics and Metabolism, ADME Sciences, Pfizer Inc, Groton, Connecticut, USA., Paryad Zanjani S; Pharmacokinetics, Dynamics and Metabolism, ADME Sciences, Pfizer Inc, Groton, Connecticut, USA., Tess DA; Pharmacokinetics, Dynamics and Metabolism, ADME Sciences, Pfizer Inc, Cambridge, Massachusetts , USA., Kimoto E; Pharmacokinetics, Dynamics and Metabolism, ADME Sciences, Pfizer Inc, Groton, Connecticut, USA., Varma MVS; Pharmacokinetics, Dynamics and Metabolism, ADME Sciences, Pfizer Inc, Groton, Connecticut, USA., Yee SW; Pharmacokinetics, Dynamics and Metabolism, ADME Sciences, Pfizer Inc, Groton, Connecticut, USA. sookwah.yee@pfizer.com.
Source: The AAPS journal [AAPS J] 2026 May 06; Vol. 28 (3). Date of Electronic Publication: 2026 May 06.
Publication Type: Journal Article
Journal Info: Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication Model: Electronic Cited Medium: Internet ISSN: 1550-7416 (Electronic) Linking ISSN: 15507416 NLM ISO Abbreviation: AAPS J Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1550-7416
DOI:10.1208/s12248-026-01251-w