High Concordance of Total Antibody and Transduction Inhibition Assays Enables Replacement of Cell-Based Antibody Testing for Preexisting Anti-AAV Immunity in Cynomolgus Monkey.
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| Title: | High Concordance of Total Antibody and Transduction Inhibition Assays Enables Replacement of Cell-Based Antibody Testing for Preexisting Anti-AAV Immunity in Cynomolgus Monkey. |
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| Authors: | Neff F; Roche Pharma Research & Early Development (pRED), Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, Basel, 4070, Switzerland. florian.neff@roche.com., Antony M; Roche Pharma Research & Early Development (pRED), Pharmaceutical Sciences, Roche Innovation Center Munich, Roche Diagnostics GmbH, Nonnenwald 2, Penzberg, 82377, Germany., Merz J; Roche Pharma Research & Early Development (pRED), Pharmaceutical Sciences, Roche Innovation Center Munich, Roche Diagnostics GmbH, Nonnenwald 2, Penzberg, 82377, Germany., Ros F; Roche Pharma Research & Early Development (pRED), Pharmaceutical Sciences, Roche Innovation Center Munich, Roche Diagnostics GmbH, Nonnenwald 2, Penzberg, 82377, Germany., Wessels U; Roche Pharma Research & Early Development (pRED), Pharmaceutical Sciences, Roche Innovation Center Munich, Roche Diagnostics GmbH, Nonnenwald 2, Penzberg, 82377, Germany., Stubenrauch KG; Roche Pharma Research & Early Development (pRED), Pharmaceutical Sciences, Roche Innovation Center Munich, Roche Diagnostics GmbH, Nonnenwald 2, Penzberg, 82377, Germany. |
| Source: | The AAPS journal [AAPS J] 2026 May 06; Vol. 28 (3). Date of Electronic Publication: 2026 May 06. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication Model: Electronic Cited Medium: Internet ISSN: 1550-7416 (Electronic) Linking ISSN: 15507416 NLM ISO Abbreviation: AAPS J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42091787 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: High Concordance of Total Antibody and Transduction Inhibition Assays Enables Replacement of Cell-Based Antibody Testing for Preexisting Anti-AAV Immunity in Cynomolgus Monkey. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Neff+F%22">Neff F</searchLink>; Roche Pharma Research & Early Development (pRED), Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, Basel, 4070, Switzerland. florian.neff@roche.com.<br /><searchLink fieldCode="AU" term="%22Antony+M%22">Antony M</searchLink>; Roche Pharma Research & Early Development (pRED), Pharmaceutical Sciences, Roche Innovation Center Munich, Roche Diagnostics GmbH, Nonnenwald 2, Penzberg, 82377, Germany.<br /><searchLink fieldCode="AU" term="%22Merz+J%22">Merz J</searchLink>; Roche Pharma Research & Early Development (pRED), Pharmaceutical Sciences, Roche Innovation Center Munich, Roche Diagnostics GmbH, Nonnenwald 2, Penzberg, 82377, Germany.<br /><searchLink fieldCode="AU" term="%22Ros+F%22">Ros F</searchLink>; Roche Pharma Research & Early Development (pRED), Pharmaceutical Sciences, Roche Innovation Center Munich, Roche Diagnostics GmbH, Nonnenwald 2, Penzberg, 82377, Germany.<br /><searchLink fieldCode="AU" term="%22Wessels+U%22">Wessels U</searchLink>; Roche Pharma Research & Early Development (pRED), Pharmaceutical Sciences, Roche Innovation Center Munich, Roche Diagnostics GmbH, Nonnenwald 2, Penzberg, 82377, Germany.<br /><searchLink fieldCode="AU" term="%22Stubenrauch+KG%22">Stubenrauch KG</searchLink>; Roche Pharma Research & Early Development (pRED), Pharmaceutical Sciences, Roche Innovation Center Munich, Roche Diagnostics GmbH, Nonnenwald 2, Penzberg, 82377, Germany. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101223209%22">The AAPS journal</searchLink> [AAPS J] 2026 May 06; Vol. 28 (3). <i>Date of Electronic Publication: </i>2026 May 06. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+of+Pharmaceutical+Scientists%22">American Association of Pharmaceutical Scientists </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101223209 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1550-7416 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215507416%22">15507416 </searchLink><i>NLM ISO Abbreviation: </i>AAPS J <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42091787 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1208/s12248-026-01239-6 Languages: – Code: eng Text: English Titles: – TitleFull: High Concordance of Total Antibody and Transduction Inhibition Assays Enables Replacement of Cell-Based Antibody Testing for Preexisting Anti-AAV Immunity in Cynomolgus Monkey. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Neff F – PersonEntity: Name: NameFull: Antony M – PersonEntity: Name: NameFull: Merz J – PersonEntity: Name: NameFull: Ros F – PersonEntity: Name: NameFull: Wessels U – PersonEntity: Name: NameFull: Stubenrauch KG IsPartOfRelationships: – BibEntity: Dates: – D: 06 M: 05 Text: 2026 May 06 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1550-7416 Numbering: – Type: volume Value: 28 – Type: issue Value: 3 Titles: – TitleFull: The AAPS journal Type: main |
| ResultId | 1 |
