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mTOR inhibition enhances the antitumor efficacy of pan-RAF-MEK blockade by inhibiting the ATF4-MTHFD2 pathway.

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Title: mTOR inhibition enhances the antitumor efficacy of pan-RAF-MEK blockade by inhibiting the ATF4-MTHFD2 pathway.
Authors: Cai F; Division of Clinical and Translational Research, McGill University, Montreal, QC, Canada.; Lady Davis Institute, McGill University, Montreal, QC, Canada., Huang F; Division of Clinical and Translational Research, McGill University, Montreal, QC, Canada.; Lady Davis Institute, McGill University, Montreal, QC, Canada., Goncalves C; Lady Davis Institute, McGill University, Montreal, QC, Canada., Srikannan H; Lady Davis Institute, McGill University, Montreal, QC, Canada., Gagnon N; Lady Davis Institute, McGill University, Montreal, QC, Canada., Guettler EM; Lady Davis Institute, McGill University, Montreal, QC, Canada., Mukeba-Harchies L; Cancer Research Unit, Department of Human Biology and Toxicology, University of Mons, Mons, Belgium., Maxwell J; Division of Clinical and Translational Research, McGill University, Montreal, QC, Canada.; Lady Davis Institute, McGill University, Montreal, QC, Canada., Su J; Lady Davis Institute, McGill University, Montreal, QC, Canada., Bijian K; Lady Davis Institute, McGill University, Montreal, QC, Canada., Journe F; Cancer Research Unit, Department of Human Biology and Toxicology, University of Mons, Mons, Belgium., Rose AAN; Division of Clinical and Translational Research, McGill University, Montreal, QC, Canada.; Lady Davis Institute, McGill University, Montreal, QC, Canada., Orthwein A; Department of Radiation Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA., Del Rincón SV; Division of Clinical and Translational Research, McGill University, Montreal, QC, Canada. soniavictoria.delrincon@mcgill.ca.; Lady Davis Institute, McGill University, Montreal, QC, Canada. soniavictoria.delrincon@mcgill.ca.; Department of Oncology, McGill University, Montreal, QC, Canada. soniavictoria.delrincon@mcgill.ca., Miller WH Jr; Division of Clinical and Translational Research, McGill University, Montreal, QC, Canada. wilson.miller@mcgill.ca.; Lady Davis Institute, McGill University, Montreal, QC, Canada. wilson.miller@mcgill.ca.; Department of Oncology, McGill University, Montreal, QC, Canada. wilson.miller@mcgill.ca.
Source: Cell death & disease [Cell Death Dis] 2026 May 06; Vol. 17 (1). Date of Electronic Publication: 2026 May 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: mTOR inhibition enhances the antitumor efficacy of pan-RAF-MEK blockade by inhibiting the ATF4-MTHFD2 pathway.
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  Data: <searchLink fieldCode="AU" term="%22Cai+F%22">Cai F</searchLink>; Division of Clinical and Translational Research, McGill University, Montreal, QC, Canada.; Lady Davis Institute, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Huang+F%22">Huang F</searchLink>; Division of Clinical and Translational Research, McGill University, Montreal, QC, Canada.; Lady Davis Institute, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Goncalves+C%22">Goncalves C</searchLink>; Lady Davis Institute, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Srikannan+H%22">Srikannan H</searchLink>; Lady Davis Institute, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Gagnon+N%22">Gagnon N</searchLink>; Lady Davis Institute, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Guettler+EM%22">Guettler EM</searchLink>; Lady Davis Institute, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Mukeba-Harchies+L%22">Mukeba-Harchies L</searchLink>; Cancer Research Unit, Department of Human Biology and Toxicology, University of Mons, Mons, Belgium.<br /><searchLink fieldCode="AU" term="%22Maxwell+J%22">Maxwell J</searchLink>; Division of Clinical and Translational Research, McGill University, Montreal, QC, Canada.; Lady Davis Institute, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Su+J%22">Su J</searchLink>; Lady Davis Institute, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Bijian+K%22">Bijian K</searchLink>; Lady Davis Institute, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Journe+F%22">Journe F</searchLink>; Cancer Research Unit, Department of Human Biology and Toxicology, University of Mons, Mons, Belgium.<br /><searchLink fieldCode="AU" term="%22Rose+AAN%22">Rose AAN</searchLink>; Division of Clinical and Translational Research, McGill University, Montreal, QC, Canada.; Lady Davis Institute, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Orthwein+A%22">Orthwein A</searchLink>; Department of Radiation Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Del+Rincón+SV%22">Del Rincón SV</searchLink>; Division of Clinical and Translational Research, McGill University, Montreal, QC, Canada. soniavictoria.delrincon@mcgill.ca.; Lady Davis Institute, McGill University, Montreal, QC, Canada. soniavictoria.delrincon@mcgill.ca.; Department of Oncology, McGill University, Montreal, QC, Canada. soniavictoria.delrincon@mcgill.ca.<br /><searchLink fieldCode="AU" term="%22Miller+WH+Jr%22">Miller WH Jr</searchLink>; Division of Clinical and Translational Research, McGill University, Montreal, QC, Canada. wilson.miller@mcgill.ca.; Lady Davis Institute, McGill University, Montreal, QC, Canada. wilson.miller@mcgill.ca.; Department of Oncology, McGill University, Montreal, QC, Canada. wilson.miller@mcgill.ca.
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  Data: <searchLink fieldCode="JN" term="%22101524092%22">Cell death & disease</searchLink> [Cell Death Dis] 2026 May 06; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 May 06.
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              Text: 2026 May 06
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