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Six1 haploinsufficiency is associated with activation of NF-κB and TNF-related transcriptional signatures in aging mice.

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Title: Six1 haploinsufficiency is associated with activation of NF-κB and TNF-related transcriptional signatures in aging mice.
Authors: Guo T; Jiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, 211166, China.; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China., Liu H; Jiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, 211166, China.; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China., Ma J; Jiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, 211166, China.; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China., Yan H; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China., Chen Y; The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Inner Mongolia University, Hohhot, 010070, China.; National Center of Technology Innovation for Dairy, Hohhot, 010020, China., Zhao L; Jiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, 211166, China.; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China., Guo X; Jiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, 211166, China.; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China., Lv L; Laboratory Animal Center, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China., Wang Y; Laboratory Animal Center, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China., Cheng L; Jiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, 211166, China.; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China., Yang G; Jiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, 211166, China.; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China., Zhang Y; Jiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, 211166, China.; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China., Yu J; Jiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, 211166, China.; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China., Wang X; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China., Duo S; Laboratory Animal Center, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. duoshuguang@ioz.ac.cn., Li X; The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Inner Mongolia University, Hohhot, 010070, China. lixh@imu.edu.cn.; National Center of Technology Innovation for Dairy, Hohhot, 010020, China. lixh@imu.edu.cn.; Inner Mongolia Saikexing Institute of Breeding and Reproductive Biotechnology in Domestic Animal, Hohhot, 011517, China. lixh@imu.edu.cn., Li R; Jiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, 211166, China. lirongfeng@njmu.edu.cn.; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China. lirongfeng@njmu.edu.cn.; Inner Mongolia Saikexing Institute of Breeding and Reproductive Biotechnology in Domestic Animal, Hohhot, 011517, China. lirongfeng@njmu.edu.cn.; Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, 210006, China. lirongfeng@njmu.edu.cn.
Source: Cell death & disease [Cell Death Dis] 2026 May 06; Vol. 17 (1). Date of Electronic Publication: 2026 May 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Six1 haploinsufficiency is associated with activation of NF-κB and TNF-related transcriptional signatures in aging mice.
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  Data: <searchLink fieldCode="AU" term="%22Guo+T%22">Guo T</searchLink>; Jiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, 211166, China.; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.<br /><searchLink fieldCode="AU" term="%22Liu+H%22">Liu H</searchLink>; Jiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, 211166, China.; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.<br /><searchLink fieldCode="AU" term="%22Ma+J%22">Ma J</searchLink>; Jiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, 211166, China.; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.<br /><searchLink fieldCode="AU" term="%22Yan+H%22">Yan H</searchLink>; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Inner Mongolia University, Hohhot, 010070, China.; National Center of Technology Innovation for Dairy, Hohhot, 010020, China.<br /><searchLink fieldCode="AU" term="%22Zhao+L%22">Zhao L</searchLink>; Jiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, 211166, China.; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.<br /><searchLink fieldCode="AU" term="%22Guo+X%22">Guo X</searchLink>; Jiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, 211166, China.; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.<br /><searchLink fieldCode="AU" term="%22Lv+L%22">Lv L</searchLink>; Laboratory Animal Center, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Laboratory Animal Center, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.<br /><searchLink fieldCode="AU" term="%22Cheng+L%22">Cheng L</searchLink>; Jiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, 211166, China.; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.<br /><searchLink fieldCode="AU" term="%22Yang+G%22">Yang G</searchLink>; Jiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, 211166, China.; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Jiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, 211166, China.; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.<br /><searchLink fieldCode="AU" term="%22Yu+J%22">Yu J</searchLink>; Jiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, 211166, China.; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.<br /><searchLink fieldCode="AU" term="%22Duo+S%22">Duo S</searchLink>; Laboratory Animal Center, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. duoshuguang@ioz.ac.cn.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Inner Mongolia University, Hohhot, 010070, China. lixh@imu.edu.cn.; National Center of Technology Innovation for Dairy, Hohhot, 010020, China. lixh@imu.edu.cn.; Inner Mongolia Saikexing Institute of Breeding and Reproductive Biotechnology in Domestic Animal, Hohhot, 011517, China. lixh@imu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Li+R%22">Li R</searchLink>; Jiangsu Provincial Key Laboratory of Biological Therapy for Organ Failure, Nanjing Medical University, Nanjing, 211166, China. lirongfeng@njmu.edu.cn.; State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China. lirongfeng@njmu.edu.cn.; Inner Mongolia Saikexing Institute of Breeding and Reproductive Biotechnology in Domestic Animal, Hohhot, 011517, China. lirongfeng@njmu.edu.cn.; Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, 210006, China. lirongfeng@njmu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101524092%22">Cell death & disease</searchLink> [Cell Death Dis] 2026 May 06; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 May 06.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101524092 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-4889 (Electronic) <i>NLM ISO Abbreviation: </i>Cell Death Dis <i>Subsets: </i>MEDLINE
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