RNA-triggered cell killing with CRISPR-Cas12a2.

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Title: RNA-triggered cell killing with CRISPR-Cas12a2.
Authors: Scholz P; Akribion Therapeutics GmbH, Zwingenberg, Germany. paul.scholz@akribion-therapeutics.com., Thompson J; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA., Crosby KT; Department of Chemistry and Biochemistry, Utah State University, Logan, UT, USA., Fauth T; Akribion Therapeutics GmbH, Zwingenberg, Germany., Krah NM; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA., Schlauderaff G; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA., Back R; Akribion Therapeutics GmbH, Zwingenberg, Germany., Berkheimer ZA; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA., Jolley A; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA., Sombroek D; Akribion Therapeutics GmbH, Zwingenberg, Germany., Medert R; Akribion Therapeutics GmbH, Zwingenberg, Germany., Zurek C; BRAIN Biotech AG, Zwingenberg, Germany., Dmytrenko O; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, Germany., Wilson E; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Schut FT; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, Germany., Rutter J; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City, UT, USA., Zhang X; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Krohn M; Akribion Therapeutics GmbH, Zwingenberg, Germany., Jackson RN; Department of Chemistry and Biochemistry, Utah State University, Logan, UT, USA. ryan.jackson@usu.edu., Beisel CL; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, Germany. chase.beisel@helmholtz-hiri.de.; Medical Faculty, University of Würzburg, Würzburg, Germany. chase.beisel@helmholtz-hiri.de., Liu Y; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA. yang.liu@biochem.utah.edu.
Source: Nature [Nature] 2026 Jul; Vol. 655 (8121), pp. 230-239. Date of Electronic Publication: 2026 May 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Scholz+P%22">Scholz P</searchLink>; Akribion Therapeutics GmbH, Zwingenberg, Germany. paul.scholz@akribion-therapeutics.com.<br /><searchLink fieldCode="AU" term="%22Thompson+J%22">Thompson J</searchLink>; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Crosby+KT%22">Crosby KT</searchLink>; Department of Chemistry and Biochemistry, Utah State University, Logan, UT, USA.<br /><searchLink fieldCode="AU" term="%22Fauth+T%22">Fauth T</searchLink>; Akribion Therapeutics GmbH, Zwingenberg, Germany.<br /><searchLink fieldCode="AU" term="%22Krah+NM%22">Krah NM</searchLink>; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Schlauderaff+G%22">Schlauderaff G</searchLink>; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Back+R%22">Back R</searchLink>; Akribion Therapeutics GmbH, Zwingenberg, Germany.<br /><searchLink fieldCode="AU" term="%22Berkheimer+ZA%22">Berkheimer ZA</searchLink>; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Jolley+A%22">Jolley A</searchLink>; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Sombroek+D%22">Sombroek D</searchLink>; Akribion Therapeutics GmbH, Zwingenberg, Germany.<br /><searchLink fieldCode="AU" term="%22Medert+R%22">Medert R</searchLink>; Akribion Therapeutics GmbH, Zwingenberg, Germany.<br /><searchLink fieldCode="AU" term="%22Zurek+C%22">Zurek C</searchLink>; BRAIN Biotech AG, Zwingenberg, Germany.<br /><searchLink fieldCode="AU" term="%22Dmytrenko+O%22">Dmytrenko O</searchLink>; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Wilson+E%22">Wilson E</searchLink>; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Schut+FT%22">Schut FT</searchLink>; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Rutter+J%22">Rutter J</searchLink>; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.; Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Krohn+M%22">Krohn M</searchLink>; Akribion Therapeutics GmbH, Zwingenberg, Germany.<br /><searchLink fieldCode="AU" term="%22Jackson+RN%22">Jackson RN</searchLink>; Department of Chemistry and Biochemistry, Utah State University, Logan, UT, USA. ryan.jackson@usu.edu.<br /><searchLink fieldCode="AU" term="%22Beisel+CL%22">Beisel CL</searchLink>; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), Würzburg, Germany. chase.beisel@helmholtz-hiri.de.; Medical Faculty, University of Würzburg, Würzburg, Germany. chase.beisel@helmholtz-hiri.de.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA. yang.liu@biochem.utah.edu.
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  Data: <searchLink fieldCode="JN" term="%220410462%22">Nature</searchLink> [Nature] 2026 Jul; Vol. 655 (8121), pp. 230-239. <i>Date of Electronic Publication: </i>2026 May 06.
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